The Influence of Age on Complications and Overall Survival After Ivor Lewis Totally Minimally Invasive Esophagectomy
Background The number of elderly patients suffering from esophageal cancer is increasing, due to an increasing incidence of esophageal cancer and increasing life expectancy. However, the effect of age on morbidity, mortality, and survival after Ivor Lewis total minimally invasive esophagectomy (TMIE...
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Veröffentlicht in: | Journal of gastrointestinal surgery 2019-07, Vol.23 (7), p.1293-1300 |
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creator | Baranov, Nikolaj S. van Workum, Frans van der Maas, Jolijn Kouwenhoven, Ewout van Det, Marc van den Wildenberg, Frits J. H. Polat, Fatih Nieuwenhuijzen, Grard A. P. Luyer, Misha D. P. Rosman, Camiel |
description | Background
The number of elderly patients suffering from esophageal cancer is increasing, due to an increasing incidence of esophageal cancer and increasing life expectancy. However, the effect of age on morbidity, mortality, and survival after Ivor Lewis total minimally invasive esophagectomy (TMIE) is not well known.
Methods
A prospectively documented database from December 2010 to June 2017 was analyzed, including all patients who underwent Ivor Lewis TMIE for esophageal cancer in three Dutch high-volume esophageal cancer centers. Patients younger than 75 years (younger group) were compared to patients aged 75 years or older (elderly group). Baseline patient characteristics and perioperative data were included. Surgical complications were graded using the Clavien-Dindo scale. The primary outcome was postoperative complications Clavien-Dindo ≥ 3. Secondary outcome parameters were postoperative complications, in-hospital mortality, 30- and 90-day mortality and survival.
Results
Four hundred and forty-six patients were included, 357 in the younger and 89 in the elderly group. No significant differences were recorded regarding baseline patient characteristics. There was no significant difference in complications graded Clavien-Dindo ≥ 3 and overall complications, short-term mortality, and survival. Delirium occurred in 27.0% in the elderly and 11.8% in the younger group (
p
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doi_str_mv | 10.1007/s11605-018-4062-9 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6591183</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2158557704</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-49443cc623b441b3cf62b011ec4103e094808c47654ac33acd9d93523ae880f83</originalsourceid><addsrcrecordid>eNp1kU1rGzEQhpfS0ny0P6CXIuill21Hq49dXQrGJKnBJYe40JuQ5VlbYVdypd0t_vdR4jT9gJxmYJ55Z17eonhH4RMFqD8nSiWIEmhTcpBVqV4Up7SpWcllJV_mHhQtKyF-nBRnKd0C0Dqzr4sTBkIKkOq0GFY7JAvfdiN6iyS0ZLbNxZN56Peds2ZwwSdi_IZcTxhN15GbMU5uMh2ZtQNGsphCJEv85RJZhSEDB_LNedc_dAs_meQmJBcp7Hdmi3YI_eFN8ao1XcK3j_W8-H55sZp_LZfXV4v5bFlaXsNQcsU5s1ZWbM05XTPbymoNlKLlFBiC4g00GZWCG8uYsRu1UUxUzGDTQNuw8-LLUXc_rnvcWPRDdqD3MX8XDzoYp_-deLfT2zBpKRSlDcsCHx8FYvg5Yhp075LFrjMew5h0RUUjRF0Dz-iH_9DbMEaf7T1QIHitZKbokbIxpBSxfXqGgr7PVB8z1TknfZ-pVnnn_d8unjZ-h5iB6gikPPJbjH9OP696B3n4rUA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2158054796</pqid></control><display><type>article</type><title>The Influence of Age on Complications and Overall Survival After Ivor Lewis Totally Minimally Invasive Esophagectomy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Baranov, Nikolaj S. ; van Workum, Frans ; van der Maas, Jolijn ; Kouwenhoven, Ewout ; van Det, Marc ; van den Wildenberg, Frits J. H. ; Polat, Fatih ; Nieuwenhuijzen, Grard A. P. ; Luyer, Misha D. P. ; Rosman, Camiel</creator><creatorcontrib>Baranov, Nikolaj S. ; van Workum, Frans ; van der Maas, Jolijn ; Kouwenhoven, Ewout ; van Det, Marc ; van den Wildenberg, Frits J. H. ; Polat, Fatih ; Nieuwenhuijzen, Grard A. P. ; Luyer, Misha D. P. ; Rosman, Camiel</creatorcontrib><description>Background
The number of elderly patients suffering from esophageal cancer is increasing, due to an increasing incidence of esophageal cancer and increasing life expectancy. However, the effect of age on morbidity, mortality, and survival after Ivor Lewis total minimally invasive esophagectomy (TMIE) is not well known.
Methods
A prospectively documented database from December 2010 to June 2017 was analyzed, including all patients who underwent Ivor Lewis TMIE for esophageal cancer in three Dutch high-volume esophageal cancer centers. Patients younger than 75 years (younger group) were compared to patients aged 75 years or older (elderly group). Baseline patient characteristics and perioperative data were included. Surgical complications were graded using the Clavien-Dindo scale. The primary outcome was postoperative complications Clavien-Dindo ≥ 3. Secondary outcome parameters were postoperative complications, in-hospital mortality, 30- and 90-day mortality and survival.
Results
Four hundred and forty-six patients were included, 357 in the younger and 89 in the elderly group. No significant differences were recorded regarding baseline patient characteristics. There was no significant difference in complications graded Clavien-Dindo ≥ 3 and overall complications, short-term mortality, and survival. Delirium occurred in 27.0% in the elderly and 11.8% in the younger group (
p
< 0.001). After correction for baseline comorbidity this difference remained significant (
p
= 0.001). Median hospital length of stay was 13 days in the elderly and 11 days in the younger group (
p
= 0.010).
Conclusions
Ivor Lewis TMIE can be safely performed in selected elderly patients without increasing postoperative morbidity and mortality.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-018-4062-9</identifier><identifier>PMID: 30565069</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age Factors ; Aged ; Esophageal cancer ; Esophageal Neoplasms - mortality ; Esophageal Neoplasms - surgery ; Esophagectomy - adverse effects ; Esophagectomy - mortality ; Esophagus ; Female ; Gastroenterology ; Gastrointestinal surgery ; Hospital Mortality ; Humans ; Length of Stay ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Minimally Invasive Surgical Procedures - adverse effects ; Minimally Invasive Surgical Procedures - mortality ; Mortality ; Original ; Original Article ; Patients ; Postoperative Complications - mortality ; Retrospective Studies ; Surgery ; Survival Rate</subject><ispartof>Journal of gastrointestinal surgery, 2019-07, Vol.23 (7), p.1293-1300</ispartof><rights>The Author(s) 2018</rights><rights>Journal of Gastrointestinal Surgery is a copyright of Springer, (2018). All Rights Reserved. © 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-49443cc623b441b3cf62b011ec4103e094808c47654ac33acd9d93523ae880f83</citedby><cites>FETCH-LOGICAL-c470t-49443cc623b441b3cf62b011ec4103e094808c47654ac33acd9d93523ae880f83</cites><orcidid>0000-0002-8646-2737</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-018-4062-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-018-4062-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30565069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baranov, Nikolaj S.</creatorcontrib><creatorcontrib>van Workum, Frans</creatorcontrib><creatorcontrib>van der Maas, Jolijn</creatorcontrib><creatorcontrib>Kouwenhoven, Ewout</creatorcontrib><creatorcontrib>van Det, Marc</creatorcontrib><creatorcontrib>van den Wildenberg, Frits J. H.</creatorcontrib><creatorcontrib>Polat, Fatih</creatorcontrib><creatorcontrib>Nieuwenhuijzen, Grard A. P.</creatorcontrib><creatorcontrib>Luyer, Misha D. P.</creatorcontrib><creatorcontrib>Rosman, Camiel</creatorcontrib><title>The Influence of Age on Complications and Overall Survival After Ivor Lewis Totally Minimally Invasive Esophagectomy</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
The number of elderly patients suffering from esophageal cancer is increasing, due to an increasing incidence of esophageal cancer and increasing life expectancy. However, the effect of age on morbidity, mortality, and survival after Ivor Lewis total minimally invasive esophagectomy (TMIE) is not well known.
Methods
A prospectively documented database from December 2010 to June 2017 was analyzed, including all patients who underwent Ivor Lewis TMIE for esophageal cancer in three Dutch high-volume esophageal cancer centers. Patients younger than 75 years (younger group) were compared to patients aged 75 years or older (elderly group). Baseline patient characteristics and perioperative data were included. Surgical complications were graded using the Clavien-Dindo scale. The primary outcome was postoperative complications Clavien-Dindo ≥ 3. Secondary outcome parameters were postoperative complications, in-hospital mortality, 30- and 90-day mortality and survival.
Results
Four hundred and forty-six patients were included, 357 in the younger and 89 in the elderly group. No significant differences were recorded regarding baseline patient characteristics. There was no significant difference in complications graded Clavien-Dindo ≥ 3 and overall complications, short-term mortality, and survival. Delirium occurred in 27.0% in the elderly and 11.8% in the younger group (
p
< 0.001). After correction for baseline comorbidity this difference remained significant (
p
= 0.001). Median hospital length of stay was 13 days in the elderly and 11 days in the younger group (
p
= 0.010).
Conclusions
Ivor Lewis TMIE can be safely performed in selected elderly patients without increasing postoperative morbidity and mortality.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - mortality</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - adverse effects</subject><subject>Esophagectomy - mortality</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastrointestinal surgery</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Minimally Invasive Surgical Procedures - adverse effects</subject><subject>Minimally Invasive Surgical Procedures - mortality</subject><subject>Mortality</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Postoperative Complications - mortality</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Survival Rate</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1rGzEQhpfS0ny0P6CXIuill21Hq49dXQrGJKnBJYe40JuQ5VlbYVdypd0t_vdR4jT9gJxmYJ55Z17eonhH4RMFqD8nSiWIEmhTcpBVqV4Up7SpWcllJV_mHhQtKyF-nBRnKd0C0Dqzr4sTBkIKkOq0GFY7JAvfdiN6iyS0ZLbNxZN56Peds2ZwwSdi_IZcTxhN15GbMU5uMh2ZtQNGsphCJEv85RJZhSEDB_LNedc_dAs_meQmJBcp7Hdmi3YI_eFN8ao1XcK3j_W8-H55sZp_LZfXV4v5bFlaXsNQcsU5s1ZWbM05XTPbymoNlKLlFBiC4g00GZWCG8uYsRu1UUxUzGDTQNuw8-LLUXc_rnvcWPRDdqD3MX8XDzoYp_-deLfT2zBpKRSlDcsCHx8FYvg5Yhp075LFrjMew5h0RUUjRF0Dz-iH_9DbMEaf7T1QIHitZKbokbIxpBSxfXqGgr7PVB8z1TknfZ-pVnnn_d8unjZ-h5iB6gikPPJbjH9OP696B3n4rUA</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Baranov, Nikolaj S.</creator><creator>van Workum, Frans</creator><creator>van der Maas, Jolijn</creator><creator>Kouwenhoven, Ewout</creator><creator>van Det, Marc</creator><creator>van den Wildenberg, Frits J. H.</creator><creator>Polat, Fatih</creator><creator>Nieuwenhuijzen, Grard A. P.</creator><creator>Luyer, Misha D. P.</creator><creator>Rosman, Camiel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8646-2737</orcidid></search><sort><creationdate>20190701</creationdate><title>The Influence of Age on Complications and Overall Survival After Ivor Lewis Totally Minimally Invasive Esophagectomy</title><author>Baranov, Nikolaj S. ; van Workum, Frans ; van der Maas, Jolijn ; Kouwenhoven, Ewout ; van Det, Marc ; van den Wildenberg, Frits J. H. ; Polat, Fatih ; Nieuwenhuijzen, Grard A. P. ; Luyer, Misha D. P. ; Rosman, Camiel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-49443cc623b441b3cf62b011ec4103e094808c47654ac33acd9d93523ae880f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - mortality</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - adverse effects</topic><topic>Esophagectomy - mortality</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastrointestinal surgery</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Minimally Invasive Surgical Procedures - adverse effects</topic><topic>Minimally Invasive Surgical Procedures - mortality</topic><topic>Mortality</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Postoperative Complications - mortality</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baranov, Nikolaj S.</creatorcontrib><creatorcontrib>van Workum, Frans</creatorcontrib><creatorcontrib>van der Maas, Jolijn</creatorcontrib><creatorcontrib>Kouwenhoven, Ewout</creatorcontrib><creatorcontrib>van Det, Marc</creatorcontrib><creatorcontrib>van den Wildenberg, Frits J. H.</creatorcontrib><creatorcontrib>Polat, Fatih</creatorcontrib><creatorcontrib>Nieuwenhuijzen, Grard A. P.</creatorcontrib><creatorcontrib>Luyer, Misha D. P.</creatorcontrib><creatorcontrib>Rosman, Camiel</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baranov, Nikolaj S.</au><au>van Workum, Frans</au><au>van der Maas, Jolijn</au><au>Kouwenhoven, Ewout</au><au>van Det, Marc</au><au>van den Wildenberg, Frits J. H.</au><au>Polat, Fatih</au><au>Nieuwenhuijzen, Grard A. P.</au><au>Luyer, Misha D. P.</au><au>Rosman, Camiel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of Age on Complications and Overall Survival After Ivor Lewis Totally Minimally Invasive Esophagectomy</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>23</volume><issue>7</issue><spage>1293</spage><epage>1300</epage><pages>1293-1300</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
The number of elderly patients suffering from esophageal cancer is increasing, due to an increasing incidence of esophageal cancer and increasing life expectancy. However, the effect of age on morbidity, mortality, and survival after Ivor Lewis total minimally invasive esophagectomy (TMIE) is not well known.
Methods
A prospectively documented database from December 2010 to June 2017 was analyzed, including all patients who underwent Ivor Lewis TMIE for esophageal cancer in three Dutch high-volume esophageal cancer centers. Patients younger than 75 years (younger group) were compared to patients aged 75 years or older (elderly group). Baseline patient characteristics and perioperative data were included. Surgical complications were graded using the Clavien-Dindo scale. The primary outcome was postoperative complications Clavien-Dindo ≥ 3. Secondary outcome parameters were postoperative complications, in-hospital mortality, 30- and 90-day mortality and survival.
Results
Four hundred and forty-six patients were included, 357 in the younger and 89 in the elderly group. No significant differences were recorded regarding baseline patient characteristics. There was no significant difference in complications graded Clavien-Dindo ≥ 3 and overall complications, short-term mortality, and survival. Delirium occurred in 27.0% in the elderly and 11.8% in the younger group (
p
< 0.001). After correction for baseline comorbidity this difference remained significant (
p
= 0.001). Median hospital length of stay was 13 days in the elderly and 11 days in the younger group (
p
= 0.010).
Conclusions
Ivor Lewis TMIE can be safely performed in selected elderly patients without increasing postoperative morbidity and mortality.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30565069</pmid><doi>10.1007/s11605-018-4062-9</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8646-2737</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Age Factors Aged Esophageal cancer Esophageal Neoplasms - mortality Esophageal Neoplasms - surgery Esophagectomy - adverse effects Esophagectomy - mortality Esophagus Female Gastroenterology Gastrointestinal surgery Hospital Mortality Humans Length of Stay Male Medicine Medicine & Public Health Middle Aged Minimally Invasive Surgical Procedures - adverse effects Minimally Invasive Surgical Procedures - mortality Mortality Original Original Article Patients Postoperative Complications - mortality Retrospective Studies Surgery Survival Rate |
title | The Influence of Age on Complications and Overall Survival After Ivor Lewis Totally Minimally Invasive Esophagectomy |
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