The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery
The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery. Prospective cohort. 1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Transl...
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| Veröffentlicht in: | American journal of kidney diseases 2019-07, Vol.74 (1), p.36-46 |
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| creator | Mansour, Sherry G. Zhang, William R. Moledina, Dennis G. Coca, Steven G. Jia, Yaqi Thiessen-Philbrook, Heather McArthur, Eric Inoue, Kazunori Koyner, Jay L. Shlipak, Michael G. Wilson, F. Perry Garg, Amit X. Ishibe, Shuta Parikh, Chirag R. |
| description | The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.
Prospective cohort.
1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.
Plasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.
AKI, long AKI duration (≥7 days), and 1-year all-cause mortality.
Multivariable logistic regression.
Following cardiac surgery, plasma VEGF concentrations decreased 2-fold, and PGF and VEGFR1 concentrations increased 1.5- and 8-fold, respectively. There were no meaningful associations of preoperative concentrations of angiogenic markers with outcomes of AKI and mortality. Higher postoperative VEGF and PGF concentrations were independently associated with lower odds of AKI (adjusted ORs of 0.89 [95% CI, 0.82-0.98] and 0.69 [95% CI, 0.55-0.87], respectively), long AKI duration (0.65 [95% CI, 0.49-0.87] and 0.48 [95% CI, 0.28-0.82], respectively), and mortality (0.74 [95% CI, 0.62-0.89] and 0.46 [95% CI, 0.31-0.68], respectively). In contrast, higher postoperative VEGFR1 concentrations were independently associated with higher odds of AKI (1.56; 95% CI, 1.31-1.87), long AKI duration (1.75; 95% CI, 1.09-2.82), and mortality (2.28; 95% CI, 1.61-3.22).
Angiogenesis markers were not measured after hospital discharge, so we were unable to determine long-term trajectories of angiogenesis marker levels during recovery and follow-up.
Higher levels of postoperative proangiogenic markers, VEGF and PGF, were associated with lower AKI and mortality risk, whereas higher postoperative antiangiogenic VEGFR1 levels were associated with higher risk for AKI and mortality. |
| doi_str_mv | 10.1053/j.ajkd.2019.01.028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6591032</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0272638619301350</els_id><sourcerecordid>2205413817</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-d3d9d86616bfe9dad8deb73ce2efa948b44e116e1f1fbefa8670a1b96c3780f23</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxS0EotvCF-CAfOSS4D-J40gIKVoBrWjFgSKOlmNPdp1m7WI7lfLtyWpLBRdOI82892Y0P4TeUFJSUvP3Y6nHO1syQtuS0JIw-QxtaM14ISSXz9GGsIYVgktxhs5TGgkhLRfiJTrjpK3rtqo2yN7uAXcpBeN0dsHjMODO71zYgYfkEr7R8Q5iwj9d3uPOzBnwV2c9LPjKj3NcsPYW34SY9eTygrshQ8RbHa3TBn-f4w7i8gq9GPSU4PVjvUA_Pn-63V4W19--XG2768JUdZ0Ly21rpRBU9AO0VltpoW-4AQaDbivZVxVQKoAOdOjXlhQN0bRvheGNJAPjF-jjKfd-7g9gDfgc9aTuozvouKignfp34t1e7cKDEnVLCT8GvHsMiOHXDCmrg0sGpkl7CHNSjJG6olzSZpWyk9TEkFKE4WkNJeqIR43qiEcd8ShC1YpnNb39-8Anyx8eq-DDSQDrmx4cRJWMA2_AuggmKxvc__J_AxMto-o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2205413817</pqid></control><display><type>article</type><title>The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Mansour, Sherry G. ; Zhang, William R. ; Moledina, Dennis G. ; Coca, Steven G. ; Jia, Yaqi ; Thiessen-Philbrook, Heather ; McArthur, Eric ; Inoue, Kazunori ; Koyner, Jay L. ; Shlipak, Michael G. ; Wilson, F. Perry ; Garg, Amit X. ; Ishibe, Shuta ; Parikh, Chirag R.</creator><creatorcontrib>Mansour, Sherry G. ; Zhang, William R. ; Moledina, Dennis G. ; Coca, Steven G. ; Jia, Yaqi ; Thiessen-Philbrook, Heather ; McArthur, Eric ; Inoue, Kazunori ; Koyner, Jay L. ; Shlipak, Michael G. ; Wilson, F. Perry ; Garg, Amit X. ; Ishibe, Shuta ; Parikh, Chirag R. ; TRIBE-AKI Consortium</creatorcontrib><description>The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.
Prospective cohort.
1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.
Plasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.
AKI, long AKI duration (≥7 days), and 1-year all-cause mortality.
Multivariable logistic regression.
Following cardiac surgery, plasma VEGF concentrations decreased 2-fold, and PGF and VEGFR1 concentrations increased 1.5- and 8-fold, respectively. There were no meaningful associations of preoperative concentrations of angiogenic markers with outcomes of AKI and mortality. Higher postoperative VEGF and PGF concentrations were independently associated with lower odds of AKI (adjusted ORs of 0.89 [95% CI, 0.82-0.98] and 0.69 [95% CI, 0.55-0.87], respectively), long AKI duration (0.65 [95% CI, 0.49-0.87] and 0.48 [95% CI, 0.28-0.82], respectively), and mortality (0.74 [95% CI, 0.62-0.89] and 0.46 [95% CI, 0.31-0.68], respectively). In contrast, higher postoperative VEGFR1 concentrations were independently associated with higher odds of AKI (1.56; 95% CI, 1.31-1.87), long AKI duration (1.75; 95% CI, 1.09-2.82), and mortality (2.28; 95% CI, 1.61-3.22).
Angiogenesis markers were not measured after hospital discharge, so we were unable to determine long-term trajectories of angiogenesis marker levels during recovery and follow-up.
Higher levels of postoperative proangiogenic markers, VEGF and PGF, were associated with lower AKI and mortality risk, whereas higher postoperative antiangiogenic VEGFR1 levels were associated with higher risk for AKI and mortality.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2019.01.028</identifier><identifier>PMID: 30955944</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute kidney injury (AKI) ; Acute Kidney Injury - blood ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Acute Kidney Injury - mortality ; Aged ; AKI duration ; angiogenesis ; angiogenic growth factor ; biomarker ; Biomarkers - blood ; cardiac surgery ; Cardiac Surgical Procedures - adverse effects ; Cardiac Surgical Procedures - methods ; Creatinine - blood ; cytokine ; Endpoint Determination ; Female ; Humans ; Kidney - blood supply ; Male ; Middle Aged ; mortality ; Neovascularization, Physiologic ; Outcome Assessment, Health Care ; placental growth factor (PGF) ; Postoperative Complications - blood ; Postoperative Complications - diagnosis ; Prospective Studies ; Receptors, Vascular Endothelial Growth Factor - blood ; Risk Assessment ; soluble VEGF receptor 1 (VEGFR1) ; United States - epidemiology ; vascular endothelial growth factor A (VEGF) ; Vascular Endothelial Growth Factor A - blood ; VEGF-A</subject><ispartof>American journal of kidney diseases, 2019-07, Vol.74 (1), p.36-46</ispartof><rights>2019 National Kidney Foundation, Inc.</rights><rights>Copyright © 2019 National Kidney Foundation, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-d3d9d86616bfe9dad8deb73ce2efa948b44e116e1f1fbefa8670a1b96c3780f23</citedby><cites>FETCH-LOGICAL-c455t-d3d9d86616bfe9dad8deb73ce2efa948b44e116e1f1fbefa8670a1b96c3780f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0272638619301350$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30955944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mansour, Sherry G.</creatorcontrib><creatorcontrib>Zhang, William R.</creatorcontrib><creatorcontrib>Moledina, Dennis G.</creatorcontrib><creatorcontrib>Coca, Steven G.</creatorcontrib><creatorcontrib>Jia, Yaqi</creatorcontrib><creatorcontrib>Thiessen-Philbrook, Heather</creatorcontrib><creatorcontrib>McArthur, Eric</creatorcontrib><creatorcontrib>Inoue, Kazunori</creatorcontrib><creatorcontrib>Koyner, Jay L.</creatorcontrib><creatorcontrib>Shlipak, Michael G.</creatorcontrib><creatorcontrib>Wilson, F. Perry</creatorcontrib><creatorcontrib>Garg, Amit X.</creatorcontrib><creatorcontrib>Ishibe, Shuta</creatorcontrib><creatorcontrib>Parikh, Chirag R.</creatorcontrib><creatorcontrib>TRIBE-AKI Consortium</creatorcontrib><title>The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.
Prospective cohort.
1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.
Plasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.
AKI, long AKI duration (≥7 days), and 1-year all-cause mortality.
Multivariable logistic regression.
Following cardiac surgery, plasma VEGF concentrations decreased 2-fold, and PGF and VEGFR1 concentrations increased 1.5- and 8-fold, respectively. There were no meaningful associations of preoperative concentrations of angiogenic markers with outcomes of AKI and mortality. Higher postoperative VEGF and PGF concentrations were independently associated with lower odds of AKI (adjusted ORs of 0.89 [95% CI, 0.82-0.98] and 0.69 [95% CI, 0.55-0.87], respectively), long AKI duration (0.65 [95% CI, 0.49-0.87] and 0.48 [95% CI, 0.28-0.82], respectively), and mortality (0.74 [95% CI, 0.62-0.89] and 0.46 [95% CI, 0.31-0.68], respectively). In contrast, higher postoperative VEGFR1 concentrations were independently associated with higher odds of AKI (1.56; 95% CI, 1.31-1.87), long AKI duration (1.75; 95% CI, 1.09-2.82), and mortality (2.28; 95% CI, 1.61-3.22).
Angiogenesis markers were not measured after hospital discharge, so we were unable to determine long-term trajectories of angiogenesis marker levels during recovery and follow-up.
Higher levels of postoperative proangiogenic markers, VEGF and PGF, were associated with lower AKI and mortality risk, whereas higher postoperative antiangiogenic VEGFR1 levels were associated with higher risk for AKI and mortality.</description><subject>Acute kidney injury (AKI)</subject><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - mortality</subject><subject>Aged</subject><subject>AKI duration</subject><subject>angiogenesis</subject><subject>angiogenic growth factor</subject><subject>biomarker</subject><subject>Biomarkers - blood</subject><subject>cardiac surgery</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiac Surgical Procedures - methods</subject><subject>Creatinine - blood</subject><subject>cytokine</subject><subject>Endpoint Determination</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>Neovascularization, Physiologic</subject><subject>Outcome Assessment, Health Care</subject><subject>placental growth factor (PGF)</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - diagnosis</subject><subject>Prospective Studies</subject><subject>Receptors, Vascular Endothelial Growth Factor - blood</subject><subject>Risk Assessment</subject><subject>soluble VEGF receptor 1 (VEGFR1)</subject><subject>United States - epidemiology</subject><subject>vascular endothelial growth factor A (VEGF)</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>VEGF-A</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EotvCF-CAfOSS4D-J40gIKVoBrWjFgSKOlmNPdp1m7WI7lfLtyWpLBRdOI82892Y0P4TeUFJSUvP3Y6nHO1syQtuS0JIw-QxtaM14ISSXz9GGsIYVgktxhs5TGgkhLRfiJTrjpK3rtqo2yN7uAXcpBeN0dsHjMODO71zYgYfkEr7R8Q5iwj9d3uPOzBnwV2c9LPjKj3NcsPYW34SY9eTygrshQ8RbHa3TBn-f4w7i8gq9GPSU4PVjvUA_Pn-63V4W19--XG2768JUdZ0Ly21rpRBU9AO0VltpoW-4AQaDbivZVxVQKoAOdOjXlhQN0bRvheGNJAPjF-jjKfd-7g9gDfgc9aTuozvouKignfp34t1e7cKDEnVLCT8GvHsMiOHXDCmrg0sGpkl7CHNSjJG6olzSZpWyk9TEkFKE4WkNJeqIR43qiEcd8ShC1YpnNb39-8Anyx8eq-DDSQDrmx4cRJWMA2_AuggmKxvc__J_AxMto-o</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Mansour, Sherry G.</creator><creator>Zhang, William R.</creator><creator>Moledina, Dennis G.</creator><creator>Coca, Steven G.</creator><creator>Jia, Yaqi</creator><creator>Thiessen-Philbrook, Heather</creator><creator>McArthur, Eric</creator><creator>Inoue, Kazunori</creator><creator>Koyner, Jay L.</creator><creator>Shlipak, Michael G.</creator><creator>Wilson, F. Perry</creator><creator>Garg, Amit X.</creator><creator>Ishibe, Shuta</creator><creator>Parikh, Chirag R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190701</creationdate><title>The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery</title><author>Mansour, Sherry G. ; Zhang, William R. ; Moledina, Dennis G. ; Coca, Steven G. ; Jia, Yaqi ; Thiessen-Philbrook, Heather ; McArthur, Eric ; Inoue, Kazunori ; Koyner, Jay L. ; Shlipak, Michael G. ; Wilson, F. Perry ; Garg, Amit X. ; Ishibe, Shuta ; Parikh, Chirag R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-d3d9d86616bfe9dad8deb73ce2efa948b44e116e1f1fbefa8670a1b96c3780f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute kidney injury (AKI)</topic><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - mortality</topic><topic>Aged</topic><topic>AKI duration</topic><topic>angiogenesis</topic><topic>angiogenic growth factor</topic><topic>biomarker</topic><topic>Biomarkers - blood</topic><topic>cardiac surgery</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiac Surgical Procedures - methods</topic><topic>Creatinine - blood</topic><topic>cytokine</topic><topic>Endpoint Determination</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>Neovascularization, Physiologic</topic><topic>Outcome Assessment, Health Care</topic><topic>placental growth factor (PGF)</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - diagnosis</topic><topic>Prospective Studies</topic><topic>Receptors, Vascular Endothelial Growth Factor - blood</topic><topic>Risk Assessment</topic><topic>soluble VEGF receptor 1 (VEGFR1)</topic><topic>United States - epidemiology</topic><topic>vascular endothelial growth factor A (VEGF)</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>VEGF-A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mansour, Sherry G.</creatorcontrib><creatorcontrib>Zhang, William R.</creatorcontrib><creatorcontrib>Moledina, Dennis G.</creatorcontrib><creatorcontrib>Coca, Steven G.</creatorcontrib><creatorcontrib>Jia, Yaqi</creatorcontrib><creatorcontrib>Thiessen-Philbrook, Heather</creatorcontrib><creatorcontrib>McArthur, Eric</creatorcontrib><creatorcontrib>Inoue, Kazunori</creatorcontrib><creatorcontrib>Koyner, Jay L.</creatorcontrib><creatorcontrib>Shlipak, Michael G.</creatorcontrib><creatorcontrib>Wilson, F. Perry</creatorcontrib><creatorcontrib>Garg, Amit X.</creatorcontrib><creatorcontrib>Ishibe, Shuta</creatorcontrib><creatorcontrib>Parikh, Chirag R.</creatorcontrib><creatorcontrib>TRIBE-AKI Consortium</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mansour, Sherry G.</au><au>Zhang, William R.</au><au>Moledina, Dennis G.</au><au>Coca, Steven G.</au><au>Jia, Yaqi</au><au>Thiessen-Philbrook, Heather</au><au>McArthur, Eric</au><au>Inoue, Kazunori</au><au>Koyner, Jay L.</au><au>Shlipak, Michael G.</au><au>Wilson, F. Perry</au><au>Garg, Amit X.</au><au>Ishibe, Shuta</au><au>Parikh, Chirag R.</au><aucorp>TRIBE-AKI Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>74</volume><issue>1</issue><spage>36</spage><epage>46</epage><pages>36-46</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>The process of angiogenesis after kidney injury may determine recovery and long-term outcomes. We evaluated the association of angiogenesis markers with acute kidney injury (AKI) and mortality after cardiac surgery.
Prospective cohort.
1,444 adults undergoing cardiac surgery in the TRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) cohort.
Plasma concentrations of 2 proangiogenic markers (vascular endothelial growth factor A [VEGF] and placental growth factor [PGF]) and 1 antiangiogenic marker (soluble VEGF receptor 1 [VEGFR1]), measured pre- and postoperatively within 6 hours after surgery.
AKI, long AKI duration (≥7 days), and 1-year all-cause mortality.
Multivariable logistic regression.
Following cardiac surgery, plasma VEGF concentrations decreased 2-fold, and PGF and VEGFR1 concentrations increased 1.5- and 8-fold, respectively. There were no meaningful associations of preoperative concentrations of angiogenic markers with outcomes of AKI and mortality. Higher postoperative VEGF and PGF concentrations were independently associated with lower odds of AKI (adjusted ORs of 0.89 [95% CI, 0.82-0.98] and 0.69 [95% CI, 0.55-0.87], respectively), long AKI duration (0.65 [95% CI, 0.49-0.87] and 0.48 [95% CI, 0.28-0.82], respectively), and mortality (0.74 [95% CI, 0.62-0.89] and 0.46 [95% CI, 0.31-0.68], respectively). In contrast, higher postoperative VEGFR1 concentrations were independently associated with higher odds of AKI (1.56; 95% CI, 1.31-1.87), long AKI duration (1.75; 95% CI, 1.09-2.82), and mortality (2.28; 95% CI, 1.61-3.22).
Angiogenesis markers were not measured after hospital discharge, so we were unable to determine long-term trajectories of angiogenesis marker levels during recovery and follow-up.
Higher levels of postoperative proangiogenic markers, VEGF and PGF, were associated with lower AKI and mortality risk, whereas higher postoperative antiangiogenic VEGFR1 levels were associated with higher risk for AKI and mortality.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30955944</pmid><doi>10.1053/j.ajkd.2019.01.028</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | American journal of kidney diseases, 2019-07, Vol.74 (1), p.36-46 |
| issn | 0272-6386 1523-6838 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acute kidney injury (AKI) Acute Kidney Injury - blood Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Acute Kidney Injury - mortality Aged AKI duration angiogenesis angiogenic growth factor biomarker Biomarkers - blood cardiac surgery Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - methods Creatinine - blood cytokine Endpoint Determination Female Humans Kidney - blood supply Male Middle Aged mortality Neovascularization, Physiologic Outcome Assessment, Health Care placental growth factor (PGF) Postoperative Complications - blood Postoperative Complications - diagnosis Prospective Studies Receptors, Vascular Endothelial Growth Factor - blood Risk Assessment soluble VEGF receptor 1 (VEGFR1) United States - epidemiology vascular endothelial growth factor A (VEGF) Vascular Endothelial Growth Factor A - blood VEGF-A |
| title | The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery |
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