Human Systems Biology and Metabolic Modelling: A Review—From Disease Metabolism to Precision Medicine

In cell and molecular biology, metabolism is the only system that can be fully simulated at genome scale. Metabolic systems biology offers powerful abstraction tools to simulate all known metabolic reactions in a cell, therefore providing a snapshot that is close to its observable phenotype. In this...

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Veröffentlicht in:	BioMed research international 2019, Vol.2019 (2019), p.1-16
1. Verfasser:	Angione, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial intelligence Bioindicators Biological activity Biology Biomarkers Cancer Case studies Cell culture Cellular proteins Clinical trials Computer simulation Data integration Disease Gene expression Genome Genomes Genomics Genotype & phenotype Humans Learning algorithms Machine learning Medical research Medicine Medicine, Experimental Medicine, Preventive Metabolic Flux Analysis Metabolic networks Metabolic Networks and Pathways Metabolism Metabolites Model accuracy Modelling Molecular biology Ordinary differential equations Patients Phenotypes Physiological aspects Physiology Precision Medicine Preventive health services Protein expression Proteins Proteomics Review Science Systems Biology
Online-Zugang:	Volltext
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