Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Objectives. Diabetes mellitus is frequently accompanied by depression (diabetes−depression, DD), and DD patients are at higher risk of diabetes-related disability and mortality than diabetes patients without depression. Hippocampal degeneration is a major pathological feature of DD. Here, we investi...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2019-01, Vol.2019 (2019), p.1-9
Hauptverfasser:	Jia, Ling, Luo, Weixu, Zhao, Hongqing, Han, Yuanshan, Liu, Zhuo, Wang, Yuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Apoptosis Caspase Caspase-3 Chinese medicine Degeneration Diabetes Diabetes mellitus Disease DNA nucleotidylexotransferase DNA polymerases Extracellular signal-regulated kinase Gene expression Glutamate Glutamic acid receptors (metabotropic) Health aspects Health risks High fat diet High performance liquid chromatography Hippocampus Immunohistochemistry Insulin Kinases Laboratory animals Liquid chromatography Mental depression Metabolism Mortality Motor activity Neurons Neurosciences Open-field behavior Pathogenesis Peptides Signal transduction Spatial discrimination learning Spatial memory Streptozocin Stress Western blotting
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