Perfusion MRI in treatment evaluation of glioblastomas: Clinical relevance of current and future techniques
Treatment evaluation of patients with glioblastomas is important to aid in clinical decisions. Conventional MRI with contrast is currently the standard method, but unable to differentiate tumor progression from treatment‐related effects. Pseudoprogression appears as new enhancement, and thus mimics...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2019-01, Vol.49 (1), p.11-22 |
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| creator | van Dijken, Bart R.J. van Laar, Peter Jan Smits, Marion Dankbaar, Jan Willem Enting, Roelien H. van der Hoorn, Anouk |
| description | Treatment evaluation of patients with glioblastomas is important to aid in clinical decisions. Conventional MRI with contrast is currently the standard method, but unable to differentiate tumor progression from treatment‐related effects. Pseudoprogression appears as new enhancement, and thus mimics tumor progression on conventional MRI. Contrarily, a decrease in enhancement or edema on conventional MRI during antiangiogenic treatment can be due to pseudoresponse and is not necessarily reflective of a favorable outcome. Neovascularization is a hallmark of tumor progression but not for posttherapeutic effects. Perfusion‐weighted MRI provides a plethora of additional parameters that can help to identify this neovascularization. This review shows that perfusion MRI aids to identify tumor progression, pseudoprogression, and pseudoresponse. The review provides an overview of the most applicable perfusion MRI methods and their limitations. Finally, future developments and remaining challenges of perfusion MRI in treatment evaluation in neuro‐oncology are discussed.
Level of Evidence: 3
Technical Efficacy: Stage 4
J. Magn. Reson. Imaging 2019;49:11–22. |
| doi_str_mv | 10.1002/jmri.26306 |
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Level of Evidence: 3
Technical Efficacy: Stage 4
J. Magn. Reson. Imaging 2019;49:11–22.</description><identifier>ISSN: 1053-1807</identifier><identifier>ISSN: 1522-2586</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.26306</identifier><identifier>PMID: 30561164</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Antiangiogenics ; Brain - diagnostic imaging ; Brain Neoplasms - diagnostic imaging ; CME ; Contrast Media - pharmacology ; Disease Progression ; Edema ; Edema - diagnostic imaging ; Evaluation ; glioblastoma ; Glioblastoma - diagnostic imaging ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Angiography - methods ; Magnetic Resonance Angiography - standards ; Magnetic resonance imaging ; Neuroimaging - methods ; Parameter identification ; Perfusion ; perfusion imaging ; Reproducibility of Results ; treatment evaluation ; Tumors ; Vascularization</subject><ispartof>Journal of magnetic resonance imaging, 2019-01, Vol.49 (1), p.11-22</ispartof><rights>2018 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2019 International Society for Magnetic Resonance in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4486-7a4648b04b4ff8e89b7f0518e6a38d4125385aa0a1a8355b52e84035338d9ef23</citedby><cites>FETCH-LOGICAL-c4486-7a4648b04b4ff8e89b7f0518e6a38d4125385aa0a1a8355b52e84035338d9ef23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.26306$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.26306$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30561164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Dijken, Bart R.J.</creatorcontrib><creatorcontrib>van Laar, Peter Jan</creatorcontrib><creatorcontrib>Smits, Marion</creatorcontrib><creatorcontrib>Dankbaar, Jan Willem</creatorcontrib><creatorcontrib>Enting, Roelien H.</creatorcontrib><creatorcontrib>van der Hoorn, Anouk</creatorcontrib><title>Perfusion MRI in treatment evaluation of glioblastomas: Clinical relevance of current and future techniques</title><title>Journal of magnetic resonance imaging</title><addtitle>J Magn Reson Imaging</addtitle><description>Treatment evaluation of patients with glioblastomas is important to aid in clinical decisions. Conventional MRI with contrast is currently the standard method, but unable to differentiate tumor progression from treatment‐related effects. Pseudoprogression appears as new enhancement, and thus mimics tumor progression on conventional MRI. Contrarily, a decrease in enhancement or edema on conventional MRI during antiangiogenic treatment can be due to pseudoresponse and is not necessarily reflective of a favorable outcome. Neovascularization is a hallmark of tumor progression but not for posttherapeutic effects. Perfusion‐weighted MRI provides a plethora of additional parameters that can help to identify this neovascularization. This review shows that perfusion MRI aids to identify tumor progression, pseudoprogression, and pseudoresponse. The review provides an overview of the most applicable perfusion MRI methods and their limitations. Finally, future developments and remaining challenges of perfusion MRI in treatment evaluation in neuro‐oncology are discussed.
Level of Evidence: 3
Technical Efficacy: Stage 4
J. Magn. Reson. Imaging 2019;49:11–22.</description><subject>Antiangiogenics</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>CME</subject><subject>Contrast Media - pharmacology</subject><subject>Disease Progression</subject><subject>Edema</subject><subject>Edema - diagnostic imaging</subject><subject>Evaluation</subject><subject>glioblastoma</subject><subject>Glioblastoma - diagnostic imaging</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Magnetic Resonance Angiography - standards</subject><subject>Magnetic resonance imaging</subject><subject>Neuroimaging - methods</subject><subject>Parameter identification</subject><subject>Perfusion</subject><subject>perfusion imaging</subject><subject>Reproducibility of Results</subject><subject>treatment evaluation</subject><subject>Tumors</subject><subject>Vascularization</subject><issn>1053-1807</issn><issn>1522-2586</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1rFTEUxYNYbK1u_AMk4EaEqfl-GReCPPxoqSii65CZd9PmmUnaZFLpf9-MrxbtwtW9cH45nJuD0DNKjigh7PV2yv6IKU7UA3RAJWMdk1o9bDuRvKOarPbR41K2hJC-F_IR2udEKkqVOEA_v0J2tfgU8edvx9hHPGew8wRxxnBlQ7XzoiWHz4JPQ7BlTpMtb_A6-OhHG3CG0MA4wgKNNeflqY0b7OpcM-AZxvPoLyuUJ2jP2VDg6e08RD8-vP--_tSdfvl4vH532o1CaNWtrFBCD0QMwjkNuh9WjkiqQVmuN4IyybW0llhqNZdykAy0IFzypvbgGD9Eb3e-F3WYYDO2QNkGc5H9ZPO1Sdabf5Xoz81ZujJK9oSTvhm8vDXIaQk-m8mXEUKwEVIthlGpmWiRRENf3EO3qebYzluoVU9U-_FGvdpRY06lZHB3YSgxS4dm6dD87rDBz_-Of4f-Ka0BdAf88gGu_2NlTlqnO9Mby3GoQQ</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>van Dijken, Bart R.J.</creator><creator>van Laar, Peter Jan</creator><creator>Smits, Marion</creator><creator>Dankbaar, Jan Willem</creator><creator>Enting, Roelien H.</creator><creator>van der Hoorn, Anouk</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201901</creationdate><title>Perfusion MRI in treatment evaluation of glioblastomas: Clinical relevance of current and future techniques</title><author>van Dijken, Bart R.J. ; van Laar, Peter Jan ; Smits, Marion ; Dankbaar, Jan Willem ; Enting, Roelien H. ; van der Hoorn, Anouk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4486-7a4648b04b4ff8e89b7f0518e6a38d4125385aa0a1a8355b52e84035338d9ef23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antiangiogenics</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>CME</topic><topic>Contrast Media - pharmacology</topic><topic>Disease Progression</topic><topic>Edema</topic><topic>Edema - diagnostic imaging</topic><topic>Evaluation</topic><topic>glioblastoma</topic><topic>Glioblastoma - diagnostic imaging</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Magnetic Resonance Angiography - standards</topic><topic>Magnetic resonance imaging</topic><topic>Neuroimaging - methods</topic><topic>Parameter identification</topic><topic>Perfusion</topic><topic>perfusion imaging</topic><topic>Reproducibility of Results</topic><topic>treatment evaluation</topic><topic>Tumors</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Dijken, Bart R.J.</creatorcontrib><creatorcontrib>van Laar, Peter Jan</creatorcontrib><creatorcontrib>Smits, Marion</creatorcontrib><creatorcontrib>Dankbaar, Jan Willem</creatorcontrib><creatorcontrib>Enting, Roelien H.</creatorcontrib><creatorcontrib>van der Hoorn, Anouk</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Dijken, Bart R.J.</au><au>van Laar, Peter Jan</au><au>Smits, Marion</au><au>Dankbaar, Jan Willem</au><au>Enting, Roelien H.</au><au>van der Hoorn, Anouk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfusion MRI in treatment evaluation of glioblastomas: Clinical relevance of current and future techniques</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J Magn Reson Imaging</addtitle><date>2019-01</date><risdate>2019</risdate><volume>49</volume><issue>1</issue><spage>11</spage><epage>22</epage><pages>11-22</pages><issn>1053-1807</issn><issn>1522-2586</issn><eissn>1522-2586</eissn><abstract>Treatment evaluation of patients with glioblastomas is important to aid in clinical decisions. Conventional MRI with contrast is currently the standard method, but unable to differentiate tumor progression from treatment‐related effects. Pseudoprogression appears as new enhancement, and thus mimics tumor progression on conventional MRI. Contrarily, a decrease in enhancement or edema on conventional MRI during antiangiogenic treatment can be due to pseudoresponse and is not necessarily reflective of a favorable outcome. Neovascularization is a hallmark of tumor progression but not for posttherapeutic effects. Perfusion‐weighted MRI provides a plethora of additional parameters that can help to identify this neovascularization. This review shows that perfusion MRI aids to identify tumor progression, pseudoprogression, and pseudoresponse. The review provides an overview of the most applicable perfusion MRI methods and their limitations. Finally, future developments and remaining challenges of perfusion MRI in treatment evaluation in neuro‐oncology are discussed.
Level of Evidence: 3
Technical Efficacy: Stage 4
J. Magn. Reson. Imaging 2019;49:11–22.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30561164</pmid><doi>10.1002/jmri.26306</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antiangiogenics Brain - diagnostic imaging Brain Neoplasms - diagnostic imaging CME Contrast Media - pharmacology Disease Progression Edema Edema - diagnostic imaging Evaluation glioblastoma Glioblastoma - diagnostic imaging Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Angiography - methods Magnetic Resonance Angiography - standards Magnetic resonance imaging Neuroimaging - methods Parameter identification Perfusion perfusion imaging Reproducibility of Results treatment evaluation Tumors Vascularization |
| title | Perfusion MRI in treatment evaluation of glioblastomas: Clinical relevance of current and future techniques |
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