Regulation of ovarian cancer G protein-coupled receptor-1 expression and signaling

Ovarian cancer G protein-coupled receptor 1 (OGR1) is a recently deorphanized G protein-coupled receptor shown to signal in response to low extracellular pH (↓pH ) or certain benzodiazepines. The pleiotropic nature of OGR1 signaling in human airway smooth muscle (HASM) cells suggests that OGR1 is a...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2019-05, Vol.316 (5), p.L894-L902
Hauptverfasser:	Nayak, Ajay P, Pera, Tonio, Deshpande, Deepak A, Michael, James V, Liberato, Jennifer R, Pan, Shi, Tompkins, Eric, Morelli, Henry P, Yi, Roslyn, Wang, Nadan, Penn, Raymond B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzodiazepines Cancer Cell Adhesion Molecules - metabolism Desensitization Female HEK293 Cells Humans Hydrogen-Ion Concentration Internalization Ischemia Localization Lorazepam Lorazepam - pharmacology Lung diseases MAP Kinase Signaling System Mice Mice, Knockout Microfilament Proteins - metabolism mRNA Muscles Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Obstructive lung disease Ovarian cancer Pharmacology Phosphoproteins - metabolism Phosphorylation Pretreatment Proteins Receptors, G-Protein-Coupled - biosynthesis Respiratory System - metabolism Respiratory System - pathology Respiratory tract Signaling Smooth muscle Therapeutic applications Up-Regulation Vasodilator-stimulated phosphoprotein
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