Deferoxamine therapy reduces brain hemin accumulation after intracerebral hemorrhage in piglets

Hemopexin (Hpx) is critical for hemin scavenging after the erythrocyte lysis that occurs following intracerebral hemorrhage (ICH). Low-density lipoprotein receptor-related protein-1 (LRP1, also called CD91) is an important receptor through which the hemin-Hpx complex can undergo endocytosis. This st...

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Veröffentlicht in:	Experimental neurology 2019-08, Vol.318, p.244-250
Hauptverfasser:	Hu, Shengli, Hua, Ya, Keep, Richard F., Feng, Hua, Xi, Guohua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD91 Cerebral Hemorrhage - metabolism Cerebral Hemorrhage - pathology Deferoxamine Deferoxamine - pharmacology Hemin Hemin - metabolism Hemopexin Hemopexin - drug effects Hemopexin - metabolism Intracerebral hemorrhage Low Density Lipoprotein Receptor-Related Protein-1 - drug effects Low Density Lipoprotein Receptor-Related Protein-1 - metabolism Male Siderophores - pharmacology Swine
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