HSP90 Inhibitor, NVP-AUY922, Improves Myelination in Vitro and Supports the Maintenance of Myelinated Axons in Neuropathic Mice

Hereditary demyelinating neuropathies linked to peripheral myelin protein 22 (PMP22) involve the disruption of normal protein trafficking and are therefore relevant targets for chaperone therapy. Using a small molecule HSP90 inhibitor, EC137, in cell culture models, we previously validated the chape...

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Veröffentlicht in:	ACS chemical neuroscience 2019-06, Vol.10 (6), p.2890-2902
Hauptverfasser:	Chittoor-Vinod, Vinita G, Bazick, Hannah, Todd, Adrian G, Falk, Darin, Morelli, Kathryn H, Burgess, Robert W, Foster, Thomas C, Notterpek, Lucia
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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