Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer

KRAS mutation is a well‐known marker for poor response to targeted treatment and patient prognosis in microsatellite stable (MSS) colorectal cancer (CRC). However, variation in clinical outcomes among patients wild‐type for KRAS underlines that this is not a homogeneous population. Here, we evaluate...

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Veröffentlicht in:	International journal of cancer 2019-02, Vol.144 (4), p.841-847
Hauptverfasser:	Eilertsen, Ina A., Sveen, Anita, Strømme, Jonas M., Skotheim, Rolf I., Nesbakken, Arild, Lothe, Ragnhild A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alternative Splicing Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease-Free Survival DNA microarrays Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene set enrichment analysis Heterogeneity Humans K-Ras protein KRAS Male Medical prognosis Medical research Microsatellite Instability microsatellite stable Microsatellites Middle Aged Mucosa Mutation Patients Prognosis Proto-Oncogene Proteins p21(ras) - genetics Ribonucleic acid RNA Transcription Tumor Markers and Signatures
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