Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation
To evaluate the changes in the blood flow on retina and the optic nerve head (ONH) after conventional laser treatment and to compare it to that after patterned scanning laser (PASCAL) treatment in patients with severe nonproliferative diabetic retinopathy (S-NPDR).In this prospective, cross-sectiona...
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| Veröffentlicht in: | Medicine (Baltimore) 2019-06, Vol.98 (24), p.e16062-e16062 |
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| creator | Iwase, Takeshi Mikoshiba, Yuji Ra, Eimei Yamamoto, Kentaro Ueno, Yoshitaka Terasaki, Hiroko |
| description | To evaluate the changes in the blood flow on retina and the optic nerve head (ONH) after conventional laser treatment and to compare it to that after patterned scanning laser (PASCAL) treatment in patients with severe nonproliferative diabetic retinopathy (S-NPDR).In this prospective, cross-sectional study, the blood flow on retina and the ONH was assessed by laser speckle flowgraphy using the mean blur rate (MBR) in 39 eyes with S-NPDR before, 1, 4, 8, 12 weeks after panretinal photocoagulation (PRP). Of 39 eyes, 17eyes with 17 patients treated by conventional laser and 22 eyes with 22 patients treated by PASCAL.The mean age was 55.5 ± 11.5 years in the conventional laser group, 55.6 ± 11.8 years in the PASCAL group. The MBR-vessel, which can be dominantly expressed as retinal blood flow, was significantly reduced after PRP treated by conventional laser (P |
| doi_str_mv | 10.1097/MD.0000000000016062 |
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Of 39 eyes, 17eyes with 17 patients treated by conventional laser and 22 eyes with 22 patients treated by PASCAL.The mean age was 55.5 ± 11.5 years in the conventional laser group, 55.6 ± 11.8 years in the PASCAL group. The MBR-vessel, which can be dominantly expressed as retinal blood flow, was significantly reduced after PRP treated by conventional laser (P < .001), but did not change after PRP treated by PASCAL. The ratio of MBR-vessel to the baseline was significantly lower in the conventional laser group only at Week 1 (P = .045). The MBR-tissue, which can be dominantly expressed as the ONH blood flow, did not significantly change after PRP in the both group. The multiple stepwise regression analysis revealed that the laser burns was an independent factor significantly correlated with the ratio of MBR-vessel at Week 1 to the baseline (β = -0.550, P = .012).The retinal blood flow was significantly reduced during the 12 weeks only after completion of PRP by conventional laser treatment. Our results indicate that short pulse on PRP treatment performed by the PASCAL would not significantly reduce the retinal blood flow.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000016062</identifier><identifier>PMID: 31192968</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Cross-Sectional Studies ; Diabetic Retinopathy - diagnostic imaging ; Diabetic Retinopathy - physiopathology ; Diabetic Retinopathy - therapy ; Female ; Humans ; Laser Therapy - methods ; Male ; Middle Aged ; Observational Study ; Optic Disk - blood supply ; Optic Disk - diagnostic imaging ; Optic Disk - physiopathology ; Prospective Studies ; Regional Blood Flow ; Rheology ; Treatment Outcome</subject><ispartof>Medicine (Baltimore), 2019-06, Vol.98 (24), p.e16062-e16062</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5163-a161123db4cd080b5cd03b1c7349e81b421ed9ae894297752de3c2e0cf0dc3263</citedby><cites>FETCH-LOGICAL-c5163-a161123db4cd080b5cd03b1c7349e81b421ed9ae894297752de3c2e0cf0dc3263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587595/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587595/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31192968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iwase, Takeshi</creatorcontrib><creatorcontrib>Mikoshiba, Yuji</creatorcontrib><creatorcontrib>Ra, Eimei</creatorcontrib><creatorcontrib>Yamamoto, Kentaro</creatorcontrib><creatorcontrib>Ueno, Yoshitaka</creatorcontrib><creatorcontrib>Terasaki, Hiroko</creatorcontrib><title>Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To evaluate the changes in the blood flow on retina and the optic nerve head (ONH) after conventional laser treatment and to compare it to that after patterned scanning laser (PASCAL) treatment in patients with severe nonproliferative diabetic retinopathy (S-NPDR).In this prospective, cross-sectional study, the blood flow on retina and the ONH was assessed by laser speckle flowgraphy using the mean blur rate (MBR) in 39 eyes with S-NPDR before, 1, 4, 8, 12 weeks after panretinal photocoagulation (PRP). Of 39 eyes, 17eyes with 17 patients treated by conventional laser and 22 eyes with 22 patients treated by PASCAL.The mean age was 55.5 ± 11.5 years in the conventional laser group, 55.6 ± 11.8 years in the PASCAL group. The MBR-vessel, which can be dominantly expressed as retinal blood flow, was significantly reduced after PRP treated by conventional laser (P < .001), but did not change after PRP treated by PASCAL. The ratio of MBR-vessel to the baseline was significantly lower in the conventional laser group only at Week 1 (P = .045). The MBR-tissue, which can be dominantly expressed as the ONH blood flow, did not significantly change after PRP in the both group. The multiple stepwise regression analysis revealed that the laser burns was an independent factor significantly correlated with the ratio of MBR-vessel at Week 1 to the baseline (β = -0.550, P = .012).The retinal blood flow was significantly reduced during the 12 weeks only after completion of PRP by conventional laser treatment. Our results indicate that short pulse on PRP treatment performed by the PASCAL would not significantly reduce the retinal blood flow.</description><subject>Cross-Sectional Studies</subject><subject>Diabetic Retinopathy - diagnostic imaging</subject><subject>Diabetic Retinopathy - physiopathology</subject><subject>Diabetic Retinopathy - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Laser Therapy - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Optic Disk - blood supply</subject><subject>Optic Disk - diagnostic imaging</subject><subject>Optic Disk - physiopathology</subject><subject>Prospective Studies</subject><subject>Regional Blood Flow</subject><subject>Rheology</subject><subject>Treatment Outcome</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9v1DAQxS0EotvCJ0BCPnJJ8fhvfEFCbSlIrbjA2XIcpxvw2sFOdsW3x7tbSosvT5r5zZuRH0JvgJwD0er97eU5-fdAEkmfoRUIJhuhJX-OVoRQ0Sit-Ak6LeVHhZii_CU6YQCaatmuUL7a2rDYeUwRpwF3IaUeDyHt8L4wzaPD0eetx2tve2yH2Wc82blKxMXZiG3ssUtx6-PewwYcbDkwMft53BemdZqTS_ZuCYc9r9CLwYbiX9_rGfr-6erbxefm5uv1l4uPN40TIFljQQJQ1nfc9aQlnajCOnCKce1b6DgF32vrW82pVkrQ3jNHPXED6R2jkp2hD0ffaek2vnf1wmyDmfK4sfm3SXY0TztxXJu7tDVStEpoUQ3e3Rvk9GvxZTabsTgfgo0-LcVQyqUGaLmqKDuiLqdSsh8e1gAx-7TM7aX5P6069fbxhQ8zf-OpAD8CuxTql5efYdn5bGoWYV4f_ITStKEENJHASVMrkrE_6mqiag</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Iwase, Takeshi</creator><creator>Mikoshiba, Yuji</creator><creator>Ra, Eimei</creator><creator>Yamamoto, Kentaro</creator><creator>Ueno, Yoshitaka</creator><creator>Terasaki, Hiroko</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation</title><author>Iwase, Takeshi ; Mikoshiba, Yuji ; Ra, Eimei ; Yamamoto, Kentaro ; Ueno, Yoshitaka ; Terasaki, Hiroko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5163-a161123db4cd080b5cd03b1c7349e81b421ed9ae894297752de3c2e0cf0dc3263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cross-Sectional Studies</topic><topic>Diabetic Retinopathy - diagnostic imaging</topic><topic>Diabetic Retinopathy - physiopathology</topic><topic>Diabetic Retinopathy - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Laser Therapy - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Optic Disk - blood supply</topic><topic>Optic Disk - diagnostic imaging</topic><topic>Optic Disk - physiopathology</topic><topic>Prospective Studies</topic><topic>Regional Blood Flow</topic><topic>Rheology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iwase, Takeshi</creatorcontrib><creatorcontrib>Mikoshiba, Yuji</creatorcontrib><creatorcontrib>Ra, Eimei</creatorcontrib><creatorcontrib>Yamamoto, Kentaro</creatorcontrib><creatorcontrib>Ueno, Yoshitaka</creatorcontrib><creatorcontrib>Terasaki, Hiroko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwase, Takeshi</au><au>Mikoshiba, Yuji</au><au>Ra, Eimei</au><au>Yamamoto, Kentaro</au><au>Ueno, Yoshitaka</au><au>Terasaki, Hiroko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>98</volume><issue>24</issue><spage>e16062</spage><epage>e16062</epage><pages>e16062-e16062</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>To evaluate the changes in the blood flow on retina and the optic nerve head (ONH) after conventional laser treatment and to compare it to that after patterned scanning laser (PASCAL) treatment in patients with severe nonproliferative diabetic retinopathy (S-NPDR).In this prospective, cross-sectional study, the blood flow on retina and the ONH was assessed by laser speckle flowgraphy using the mean blur rate (MBR) in 39 eyes with S-NPDR before, 1, 4, 8, 12 weeks after panretinal photocoagulation (PRP). Of 39 eyes, 17eyes with 17 patients treated by conventional laser and 22 eyes with 22 patients treated by PASCAL.The mean age was 55.5 ± 11.5 years in the conventional laser group, 55.6 ± 11.8 years in the PASCAL group. The MBR-vessel, which can be dominantly expressed as retinal blood flow, was significantly reduced after PRP treated by conventional laser (P < .001), but did not change after PRP treated by PASCAL. The ratio of MBR-vessel to the baseline was significantly lower in the conventional laser group only at Week 1 (P = .045). The MBR-tissue, which can be dominantly expressed as the ONH blood flow, did not significantly change after PRP in the both group. The multiple stepwise regression analysis revealed that the laser burns was an independent factor significantly correlated with the ratio of MBR-vessel at Week 1 to the baseline (β = -0.550, P = .012).The retinal blood flow was significantly reduced during the 12 weeks only after completion of PRP by conventional laser treatment. Our results indicate that short pulse on PRP treatment performed by the PASCAL would not significantly reduce the retinal blood flow.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>31192968</pmid><doi>10.1097/MD.0000000000016062</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Cross-Sectional Studies Diabetic Retinopathy - diagnostic imaging Diabetic Retinopathy - physiopathology Diabetic Retinopathy - therapy Female Humans Laser Therapy - methods Male Middle Aged Observational Study Optic Disk - blood supply Optic Disk - diagnostic imaging Optic Disk - physiopathology Prospective Studies Regional Blood Flow Rheology Treatment Outcome |
| title | Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation |
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