Overexpression of cyclooxygenase-2 in adipocytes reduces fat accumulation in inguinal white adipose tissue and hepatic steatosis in high-fat fed mice

Cyclooxygenases are known as important regulators of metabolism and immune processes via conversion of C20 fatty acids into various regulatory lipid mediators, and cyclooxygenase activity has been implicated in browning of white adipose tissues. We generated transgenic (TG) C57BL/6 mice expressing t...

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Veröffentlicht in:	Scientific reports 2019-06, Vol.9 (1), p.8979-13, Article 8979
Hauptverfasser:	Banhos Danneskiold-Samsøe, Niels, Sonne, Si Brask, Larsen, Jeppe Madura, Hansen, Ann Normann, Fjære, Even, Isidor, Marie Sophie, Petersen, Sidsel, Henningsen, Jeanette, Severi, Ilenia, Sartini, Loris, Schober, Yvonne, Wolf, Jacqueline, Nockher, W. Andreas, Wolfrum, Christian, Cinti, Saverio, Sina, Christian, Hansen, Jacob B., Madsen, Lise, Brix, Susanne, Kristiansen, Karsten
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 14/63 38/39 631/250 631/80 64/60 692/163 Adipocytes Adipocytes - cytology Adipocytes - metabolism Adipose tissue Adipose Tissue, White - metabolism Adiposity - genetics Animals Arginase Body Weight Cell Differentiation Cell size Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Diet, High-Fat Disease Models, Animal Energy expenditure Eosinophils - immunology Eosinophils - metabolism Fatty acids Fatty liver Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - pathology Gene Expression Glucose - metabolism Glucose tolerance High fat diet Humanities and Social Sciences Immunological tolerance Insulin Insulin - metabolism Interleukin 4 Leukocytes (eosinophilic) Lipids Liver Mice Mice, Transgenic mRNA multidisciplinary Science Science (multidisciplinary) Steatosis Transgenic mice Uncoupling protein 1
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