Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients
Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability of 209 MDR strains ( Escherichia coli n = 106, Klebsiella pneumoniae n = 78, and Enterobacter spp. n = 25) isolated from rectal...
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creator | Ramos-Vivas, José Chapartegui-González, Itziar Fernández-Martínez, Marta González-Rico, Claudia Fortún, Jesús Escudero, Rosa Marco, Francesc Linares, Laura Montejo, Miguel Aranzamendi, Maitane Muñoz, Patricia Valerio, Maricela Aguado, Jose María Resino, Elena Ahufinger, Irene Gracia Vega, Aurora Paz Martínez-Martínez, Luis Fariñas, María Carmen |
description | Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability of 209 MDR strains (
Escherichia coli
n = 106,
Klebsiella pneumoniae
n = 78, and
Enterobacter
spp. n = 25) isolated from rectal swabs in the first 48 hours before or after kidney (93 patients), liver (60 patients) or kidney/pancreas transplants (5 patients) were evaluated by using a microplate assay. Thirty-nine strains were isolated before transplant and 170 strains were isolated post-transplant. Overall, 16% of
E. coli
strains, 73% of
K. pneumoniae
strains and 4%
Enterobacter
strains showed moderate or strong biofilm production. Nine strains isolated from infection sites after transplantation were responsible of infections in the first month. Of these, 4
K. pneumoniae
, 1
E. coli
and 1
Enterobacter
spp. strains isolated pre-transplant or post-transplant as colonizers caused infections in the post-transplant period. Our results suggest that
in vitro
biofilm formation could be an important factor for adhesion to intestine and colonization in MDR
K. pneumoniae
strains in SOT recipients, but this factor appears to be less important for MDR
E. coli
and
Enterobacter
spp. |
doi_str_mv | 10.1038/s41598-019-45060-y |
format | Article |
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Escherichia coli
n = 106,
Klebsiella pneumoniae
n = 78, and
Enterobacter
spp. n = 25) isolated from rectal swabs in the first 48 hours before or after kidney (93 patients), liver (60 patients) or kidney/pancreas transplants (5 patients) were evaluated by using a microplate assay. Thirty-nine strains were isolated before transplant and 170 strains were isolated post-transplant. Overall, 16% of
E. coli
strains, 73% of
K. pneumoniae
strains and 4%
Enterobacter
strains showed moderate or strong biofilm production. Nine strains isolated from infection sites after transplantation were responsible of infections in the first month. Of these, 4
K. pneumoniae
, 1
E. coli
and 1
Enterobacter
spp. strains isolated pre-transplant or post-transplant as colonizers caused infections in the post-transplant period. Our results suggest that
in vitro
biofilm formation could be an important factor for adhesion to intestine and colonization in MDR
K. pneumoniae
strains in SOT recipients, but this factor appears to be less important for MDR
E. coli
and
Enterobacter
spp.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-45060-y</identifier><identifier>PMID: 31222089</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/34 ; 631/326/107 ; 692/308 ; 96/63 ; Bacterial Infections - microbiology ; Biofilms ; Colonization ; Drug resistance ; Drug Resistance, Multiple, Bacterial - genetics ; E coli ; Enterobacter ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - isolation & purification ; Escherichia coli ; Humanities and Social Sciences ; Humans ; Infections ; Intestine ; Kidney transplantation ; Kidneys ; Klebsiella pneumoniae ; multidisciplinary ; Multidrug resistance ; Multidrug resistant organisms ; Organ Transplantation ; Pancreas transplantation ; Rectum ; Science ; Science (multidisciplinary) ; Strains (organisms) ; Transplants & implants</subject><ispartof>Scientific reports, 2019-06, Vol.9 (1), p.8928-8928, Article 8928</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-c3b8ac89953937aedd5f2e40082623615af6028da62b2e119f5c78509f95a6393</citedby><cites>FETCH-LOGICAL-c540t-c3b8ac89953937aedd5f2e40082623615af6028da62b2e119f5c78509f95a6393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586660/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586660/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31222089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos-Vivas, José</creatorcontrib><creatorcontrib>Chapartegui-González, Itziar</creatorcontrib><creatorcontrib>Fernández-Martínez, Marta</creatorcontrib><creatorcontrib>González-Rico, Claudia</creatorcontrib><creatorcontrib>Fortún, Jesús</creatorcontrib><creatorcontrib>Escudero, Rosa</creatorcontrib><creatorcontrib>Marco, Francesc</creatorcontrib><creatorcontrib>Linares, Laura</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Aranzamendi, Maitane</creatorcontrib><creatorcontrib>Muñoz, Patricia</creatorcontrib><creatorcontrib>Valerio, Maricela</creatorcontrib><creatorcontrib>Aguado, Jose María</creatorcontrib><creatorcontrib>Resino, Elena</creatorcontrib><creatorcontrib>Ahufinger, Irene Gracia</creatorcontrib><creatorcontrib>Vega, Aurora Paz</creatorcontrib><creatorcontrib>Martínez-Martínez, Luis</creatorcontrib><creatorcontrib>Fariñas, María Carmen</creatorcontrib><creatorcontrib>ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI)</creatorcontrib><creatorcontrib>The ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI)</creatorcontrib><title>Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability of 209 MDR strains (
Escherichia coli
n = 106,
Klebsiella pneumoniae
n = 78, and
Enterobacter
spp. n = 25) isolated from rectal swabs in the first 48 hours before or after kidney (93 patients), liver (60 patients) or kidney/pancreas transplants (5 patients) were evaluated by using a microplate assay. Thirty-nine strains were isolated before transplant and 170 strains were isolated post-transplant. Overall, 16% of
E. coli
strains, 73% of
K. pneumoniae
strains and 4%
Enterobacter
strains showed moderate or strong biofilm production. Nine strains isolated from infection sites after transplantation were responsible of infections in the first month. Of these, 4
K. pneumoniae
, 1
E. coli
and 1
Enterobacter
spp. strains isolated pre-transplant or post-transplant as colonizers caused infections in the post-transplant period. Our results suggest that
in vitro
biofilm formation could be an important factor for adhesion to intestine and colonization in MDR
K. pneumoniae
strains in SOT recipients, but this factor appears to be less important for MDR
E. coli
and
Enterobacter
spp.</description><subject>14/34</subject><subject>631/326/107</subject><subject>692/308</subject><subject>96/63</subject><subject>Bacterial Infections - microbiology</subject><subject>Biofilms</subject><subject>Colonization</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>E coli</subject><subject>Enterobacter</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae - isolation & purification</subject><subject>Escherichia coli</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infections</subject><subject>Intestine</subject><subject>Kidney transplantation</subject><subject>Kidneys</subject><subject>Klebsiella pneumoniae</subject><subject>multidisciplinary</subject><subject>Multidrug resistance</subject><subject>Multidrug resistant organisms</subject><subject>Organ Transplantation</subject><subject>Pancreas transplantation</subject><subject>Rectum</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Strains (organisms)</subject><subject>Transplants & implants</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU9rFTEUxYMottR-ARcScONmav6_ZCNoqVUouNF1yGSSZ8pM8szNCO_bN89Xa3VhNjfh_s65uRyEXlJyQQnXb0FQafRAqBmEJIoM-yfolBEhB8YZe_rofoLOAW5JP5IZQc1zdMIpY4xoc4rgQyoxzQuOpS6upZLxuMfLOrc01XWLa4AEzeWGr3ILtYzO95KcDy5gaNWlDDhBmV0LE461LLg_0oRL3bqMO5BhNx_0Nfi0SyE3eIGeRTdDOL-vZ-jbx6uvl5-Gmy_Xny_f3wxeCtIGz0ftvDZGcsM3LkyTjCwIQjRTjCsqXVSE6ckpNrJAqYnSb7QkJhrpVNecoXdH3906LmHyfXZ1s93VtLi6t8Ul-3cnp-92W35aJbVSinSDN_cGtfxYAzS7JPBh7vuEsoJlTEhFNsKwjr7-B70ta819vQMlKBdE8E6xI-VrAaghPnyGEnuI1R5jtT1W-ytWu--iV4_XeJD8DrED_AhAb-VtqH9m_8f2DjkZsPU</recordid><startdate>20190620</startdate><enddate>20190620</enddate><creator>Ramos-Vivas, José</creator><creator>Chapartegui-González, Itziar</creator><creator>Fernández-Martínez, Marta</creator><creator>González-Rico, Claudia</creator><creator>Fortún, Jesús</creator><creator>Escudero, Rosa</creator><creator>Marco, Francesc</creator><creator>Linares, Laura</creator><creator>Montejo, Miguel</creator><creator>Aranzamendi, Maitane</creator><creator>Muñoz, Patricia</creator><creator>Valerio, Maricela</creator><creator>Aguado, Jose María</creator><creator>Resino, Elena</creator><creator>Ahufinger, Irene Gracia</creator><creator>Vega, Aurora Paz</creator><creator>Martínez-Martínez, Luis</creator><creator>Fariñas, María Carmen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190620</creationdate><title>Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients</title><author>Ramos-Vivas, José ; Chapartegui-González, Itziar ; Fernández-Martínez, Marta ; González-Rico, Claudia ; Fortún, Jesús ; Escudero, Rosa ; Marco, Francesc ; Linares, Laura ; Montejo, Miguel ; Aranzamendi, Maitane ; Muñoz, Patricia ; Valerio, Maricela ; Aguado, Jose María ; Resino, Elena ; Ahufinger, Irene Gracia ; Vega, Aurora Paz ; Martínez-Martínez, Luis ; Fariñas, María Carmen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-c3b8ac89953937aedd5f2e40082623615af6028da62b2e119f5c78509f95a6393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>14/34</topic><topic>631/326/107</topic><topic>692/308</topic><topic>96/63</topic><topic>Bacterial Infections - microbiology</topic><topic>Biofilms</topic><topic>Colonization</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>E coli</topic><topic>Enterobacter</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Enterobacteriaceae - isolation & purification</topic><topic>Escherichia coli</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infections</topic><topic>Intestine</topic><topic>Kidney transplantation</topic><topic>Kidneys</topic><topic>Klebsiella pneumoniae</topic><topic>multidisciplinary</topic><topic>Multidrug resistance</topic><topic>Multidrug resistant organisms</topic><topic>Organ Transplantation</topic><topic>Pancreas transplantation</topic><topic>Rectum</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Strains (organisms)</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos-Vivas, José</creatorcontrib><creatorcontrib>Chapartegui-González, Itziar</creatorcontrib><creatorcontrib>Fernández-Martínez, Marta</creatorcontrib><creatorcontrib>González-Rico, Claudia</creatorcontrib><creatorcontrib>Fortún, Jesús</creatorcontrib><creatorcontrib>Escudero, Rosa</creatorcontrib><creatorcontrib>Marco, Francesc</creatorcontrib><creatorcontrib>Linares, Laura</creatorcontrib><creatorcontrib>Montejo, Miguel</creatorcontrib><creatorcontrib>Aranzamendi, Maitane</creatorcontrib><creatorcontrib>Muñoz, Patricia</creatorcontrib><creatorcontrib>Valerio, Maricela</creatorcontrib><creatorcontrib>Aguado, Jose María</creatorcontrib><creatorcontrib>Resino, Elena</creatorcontrib><creatorcontrib>Ahufinger, Irene Gracia</creatorcontrib><creatorcontrib>Vega, Aurora Paz</creatorcontrib><creatorcontrib>Martínez-Martínez, Luis</creatorcontrib><creatorcontrib>Fariñas, María Carmen</creatorcontrib><creatorcontrib>ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI)</creatorcontrib><creatorcontrib>The ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI)</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos-Vivas, José</au><au>Chapartegui-González, Itziar</au><au>Fernández-Martínez, Marta</au><au>González-Rico, Claudia</au><au>Fortún, Jesús</au><au>Escudero, Rosa</au><au>Marco, Francesc</au><au>Linares, Laura</au><au>Montejo, Miguel</au><au>Aranzamendi, Maitane</au><au>Muñoz, Patricia</au><au>Valerio, Maricela</au><au>Aguado, Jose María</au><au>Resino, Elena</au><au>Ahufinger, Irene Gracia</au><au>Vega, Aurora Paz</au><au>Martínez-Martínez, Luis</au><au>Fariñas, María Carmen</au><aucorp>ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI)</aucorp><aucorp>The ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-06-20</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>8928</spage><epage>8928</epage><pages>8928-8928</pages><artnum>8928</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability of 209 MDR strains (
Escherichia coli
n = 106,
Klebsiella pneumoniae
n = 78, and
Enterobacter
spp. n = 25) isolated from rectal swabs in the first 48 hours before or after kidney (93 patients), liver (60 patients) or kidney/pancreas transplants (5 patients) were evaluated by using a microplate assay. Thirty-nine strains were isolated before transplant and 170 strains were isolated post-transplant. Overall, 16% of
E. coli
strains, 73% of
K. pneumoniae
strains and 4%
Enterobacter
strains showed moderate or strong biofilm production. Nine strains isolated from infection sites after transplantation were responsible of infections in the first month. Of these, 4
K. pneumoniae
, 1
E. coli
and 1
Enterobacter
spp. strains isolated pre-transplant or post-transplant as colonizers caused infections in the post-transplant period. Our results suggest that
in vitro
biofilm formation could be an important factor for adhesion to intestine and colonization in MDR
K. pneumoniae
strains in SOT recipients, but this factor appears to be less important for MDR
E. coli
and
Enterobacter
spp.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31222089</pmid><doi>10.1038/s41598-019-45060-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
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ispartof | Scientific reports, 2019-06, Vol.9 (1), p.8928-8928, Article 8928 |
issn | 2045-2322 2045-2322 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6586660 |
source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
subjects | 14/34 631/326/107 692/308 96/63 Bacterial Infections - microbiology Biofilms Colonization Drug resistance Drug Resistance, Multiple, Bacterial - genetics E coli Enterobacter Enterobacteriaceae - drug effects Enterobacteriaceae - isolation & purification Escherichia coli Humanities and Social Sciences Humans Infections Intestine Kidney transplantation Kidneys Klebsiella pneumoniae multidisciplinary Multidrug resistance Multidrug resistant organisms Organ Transplantation Pancreas transplantation Rectum Science Science (multidisciplinary) Strains (organisms) Transplants & implants |
title | Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T22%3A15%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biofilm%20formation%20by%20multidrug%20resistant%20Enterobacteriaceae%20strains%20isolated%20from%20solid%20organ%20transplant%20recipients&rft.jtitle=Scientific%20reports&rft.au=Ramos-Vivas,%20Jos%C3%A9&rft.aucorp=ENTHERE%20Study%20Group,%20the%20Group%20for%20Study%20of%20Infection%20in%20Transplantation%20of%20the%20Spanish%20Society%20of%20Infectious%20Diseases%20and%20Clinical%20Microbiology%20(GESITRA-SEIMC)%20and%20the%20Spanish%20Network%20for%20Research%20in%20Infectious%20Diseases%20(REIPI)&rft.date=2019-06-20&rft.volume=9&rft.issue=1&rft.spage=8928&rft.epage=8928&rft.pages=8928-8928&rft.artnum=8928&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-019-45060-y&rft_dat=%3Cproquest_pubme%3E2245607492%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2244134043&rft_id=info:pmid/31222089&rfr_iscdi=true |