SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program

The capacity for tumor cells to metastasize efficiently is directly linked to their ability to colonize secondary sites. Here we identify Six2, a developmental transcription factor, as a critical regulator of a breast cancer stem cell program that enables metastatic colonization. In several triple-n...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-02, Vol.79 (4), p.720-734
Hauptverfasser:	Oliphant, Michael U J, Vincent, Melanie Y, Galbraith, Matthew D, Pandey, Ahwan, Zaberezhnyy, Vadym, Rudra, Pratyaydipta, Johnson, Katherine R, Costello, James C, Ghosh, Debashis, DeGregori, James, Espinosa, Joaquin M, Ford, Heide L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Proliferation Female Follow-Up Studies Gene Expression Regulation, Neoplastic Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Nanog Homeobox Protein - genetics Nanog Homeobox Protein - metabolism Neoplasm Metastasis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Prognosis SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Survival Rate Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - secondary Tumor Cells, Cultured Xenograft Model Antitumor Assays
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