Use of aspirin in the prevention of colorectal cancer through TIGIT‐CD155 pathway
Colorectal cancer (CRC) is one of the most widespread malignant cancers, with a high incidence and mortality all over the world. Aspirin (ASA) otherwise known as acetylsalicylic acid, is a non‐steroidal anti‐inflammatory drug that has shown promising results in the prevention of chronic diseases, in...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2019-07, Vol.23 (7), p.4514-4522 |
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| creator | Ma, Bin Duan, Xiangguo Zhou, Qiunan Liu, Juanxi Yang, Xiaojuan Zhang, Dong Yang, Shaoqi Du, Yong Li, Hai Su, Chunxia |
| description | Colorectal cancer (CRC) is one of the most widespread malignant cancers, with a high incidence and mortality all over the world. Aspirin (ASA) otherwise known as acetylsalicylic acid, is a non‐steroidal anti‐inflammatory drug that has shown promising results in the prevention of chronic diseases, including several cancers. In previous studies, aspirin has been shown to reduce the incidence of CRC. Immune checkpoint blockade of T cell Ig and ITIM domain receptor (TIGIT) alone or combined with other immune checkpoint blockades moleculars has gained impressive results in the treatment of the melanoma and glioblastoma. Here, we found that TIGIT and Poliovirus receptor (PVR, CD155) are expressed in tumour cells; the TIGIT and CD155 protein expression in cancer tissue has been found to be significantly higher than that in the precancerous tissue. T cell Ig and ITIM domain receptor and CD226 were expressed in the lymphocytes near the tumour tissue and the adjacent tissues. Aspirin has been found to inhibit cancer cell viability and promote CRC cell apoptosis.Similarly, aspirin has also been found to increase pro‐apoptotic protein Bax's expression. We found that the expression of TIGIT decreased with an increase in the concentration of aspirin and that the suppression of TIGIT can affect the effect of aspirin on cell proliferation. In this paper, we found that aspirin attenuates cancer cell proliferation and induces CRC cells apoptosis by down‐regulating the expression of TIGIT, which provides new evidence for the application of aspirin in cancer treatment. |
| doi_str_mv | 10.1111/jcmm.14332 |
| format | Article |
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Aspirin (ASA) otherwise known as acetylsalicylic acid, is a non‐steroidal anti‐inflammatory drug that has shown promising results in the prevention of chronic diseases, including several cancers. In previous studies, aspirin has been shown to reduce the incidence of CRC. Immune checkpoint blockade of T cell Ig and ITIM domain receptor (TIGIT) alone or combined with other immune checkpoint blockades moleculars has gained impressive results in the treatment of the melanoma and glioblastoma. Here, we found that TIGIT and Poliovirus receptor (PVR, CD155) are expressed in tumour cells; the TIGIT and CD155 protein expression in cancer tissue has been found to be significantly higher than that in the precancerous tissue. T cell Ig and ITIM domain receptor and CD226 were expressed in the lymphocytes near the tumour tissue and the adjacent tissues. Aspirin has been found to inhibit cancer cell viability and promote CRC cell apoptosis.Similarly, aspirin has also been found to increase pro‐apoptotic protein Bax's expression. We found that the expression of TIGIT decreased with an increase in the concentration of aspirin and that the suppression of TIGIT can affect the effect of aspirin on cell proliferation. In this paper, we found that aspirin attenuates cancer cell proliferation and induces CRC cells apoptosis by down‐regulating the expression of TIGIT, which provides new evidence for the application of aspirin in cancer treatment.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.14332</identifier><identifier>PMID: 31090213</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Acetylsalicylic acid ; Alcohol ; Alzheimer's disease ; Antigens ; Antigens, Differentiation, T-Lymphocyte - metabolism ; Apoptosis ; Apoptosis - drug effects ; Aspirin ; Aspirin - pharmacology ; Aspirin - therapeutic use ; BAX protein ; bcl-2-Associated X Protein - metabolism ; Cancer ; Cancer therapies ; CD155 ; CD155 antigen ; CD226 ; Cell adhesion & migration ; Cell growth ; Cell Movement - drug effects ; Cell proliferation ; Cell Survival - drug effects ; Cell viability ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - prevention & control ; Disease prevention ; Flow cytometry ; Glioblastoma ; HT29 Cells ; Humans ; Immune checkpoint ; Immune system ; Immunoglobulins ; Incidence ; Inflammation ; Lymphocytes ; Lymphocytes - metabolism ; Lymphocytes T ; Medical prognosis ; Medical research ; Melanoma ; Original ; Proteins ; R&D ; Receptors, Immunologic - metabolism ; Receptors, Virus - metabolism ; Research & development ; Researchers ; Signal Transduction - drug effects ; T cell receptors ; TIGIT ; Tissues ; Tumors</subject><ispartof>Journal of cellular and molecular medicine, 2019-07, Vol.23 (7), p.4514-4522</ispartof><rights>2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4482-72aca059d81218493109a3fbcd36e73ff8f8160c0da3d9b24f9346a26ce383c43</citedby><cites>FETCH-LOGICAL-c4482-72aca059d81218493109a3fbcd36e73ff8f8160c0da3d9b24f9346a26ce383c43</cites><orcidid>0000-0002-9523-1973</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584546/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584546/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31090213$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Bin</creatorcontrib><creatorcontrib>Duan, Xiangguo</creatorcontrib><creatorcontrib>Zhou, Qiunan</creatorcontrib><creatorcontrib>Liu, Juanxi</creatorcontrib><creatorcontrib>Yang, Xiaojuan</creatorcontrib><creatorcontrib>Zhang, Dong</creatorcontrib><creatorcontrib>Yang, Shaoqi</creatorcontrib><creatorcontrib>Du, Yong</creatorcontrib><creatorcontrib>Li, Hai</creatorcontrib><creatorcontrib>Su, Chunxia</creatorcontrib><title>Use of aspirin in the prevention of colorectal cancer through TIGIT‐CD155 pathway</title><title>Journal of cellular and molecular medicine</title><addtitle>J Cell Mol Med</addtitle><description>Colorectal cancer (CRC) is one of the most widespread malignant cancers, with a high incidence and mortality all over the world. Aspirin (ASA) otherwise known as acetylsalicylic acid, is a non‐steroidal anti‐inflammatory drug that has shown promising results in the prevention of chronic diseases, including several cancers. In previous studies, aspirin has been shown to reduce the incidence of CRC. Immune checkpoint blockade of T cell Ig and ITIM domain receptor (TIGIT) alone or combined with other immune checkpoint blockades moleculars has gained impressive results in the treatment of the melanoma and glioblastoma. Here, we found that TIGIT and Poliovirus receptor (PVR, CD155) are expressed in tumour cells; the TIGIT and CD155 protein expression in cancer tissue has been found to be significantly higher than that in the precancerous tissue. T cell Ig and ITIM domain receptor and CD226 were expressed in the lymphocytes near the tumour tissue and the adjacent tissues. Aspirin has been found to inhibit cancer cell viability and promote CRC cell apoptosis.Similarly, aspirin has also been found to increase pro‐apoptotic protein Bax's expression. We found that the expression of TIGIT decreased with an increase in the concentration of aspirin and that the suppression of TIGIT can affect the effect of aspirin on cell proliferation. In this paper, we found that aspirin attenuates cancer cell proliferation and induces CRC cells apoptosis by down‐regulating the expression of TIGIT, which provides new evidence for the application of aspirin in cancer treatment.</description><subject>Acetylsalicylic acid</subject><subject>Alcohol</subject><subject>Alzheimer's disease</subject><subject>Antigens</subject><subject>Antigens, Differentiation, T-Lymphocyte - metabolism</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Aspirin</subject><subject>Aspirin - pharmacology</subject><subject>Aspirin - therapeutic use</subject><subject>BAX protein</subject><subject>bcl-2-Associated X Protein - metabolism</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>CD155</subject><subject>CD155 antigen</subject><subject>CD226</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Cell Movement - drug effects</subject><subject>Cell proliferation</subject><subject>Cell Survival - drug effects</subject><subject>Cell viability</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Disease prevention</subject><subject>Flow cytometry</subject><subject>Glioblastoma</subject><subject>HT29 Cells</subject><subject>Humans</subject><subject>Immune checkpoint</subject><subject>Immune system</subject><subject>Immunoglobulins</subject><subject>Incidence</subject><subject>Inflammation</subject><subject>Lymphocytes</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes T</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Melanoma</subject><subject>Original</subject><subject>Proteins</subject><subject>R&D</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Virus - metabolism</subject><subject>Research & development</subject><subject>Researchers</subject><subject>Signal Transduction - 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metabolism</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Aspirin</topic><topic>Aspirin - pharmacology</topic><topic>Aspirin - therapeutic use</topic><topic>BAX protein</topic><topic>bcl-2-Associated X Protein - metabolism</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>CD155</topic><topic>CD155 antigen</topic><topic>CD226</topic><topic>Cell adhesion & migration</topic><topic>Cell growth</topic><topic>Cell Movement - drug effects</topic><topic>Cell proliferation</topic><topic>Cell Survival - drug effects</topic><topic>Cell viability</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - prevention & control</topic><topic>Disease prevention</topic><topic>Flow cytometry</topic><topic>Glioblastoma</topic><topic>HT29 Cells</topic><topic>Humans</topic><topic>Immune checkpoint</topic><topic>Immune system</topic><topic>Immunoglobulins</topic><topic>Incidence</topic><topic>Inflammation</topic><topic>Lymphocytes</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes T</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Melanoma</topic><topic>Original</topic><topic>Proteins</topic><topic>R&D</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Virus - metabolism</topic><topic>Research & development</topic><topic>Researchers</topic><topic>Signal Transduction - drug effects</topic><topic>T cell receptors</topic><topic>TIGIT</topic><topic>Tissues</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Bin</creatorcontrib><creatorcontrib>Duan, Xiangguo</creatorcontrib><creatorcontrib>Zhou, Qiunan</creatorcontrib><creatorcontrib>Liu, Juanxi</creatorcontrib><creatorcontrib>Yang, Xiaojuan</creatorcontrib><creatorcontrib>Zhang, Dong</creatorcontrib><creatorcontrib>Yang, Shaoqi</creatorcontrib><creatorcontrib>Du, Yong</creatorcontrib><creatorcontrib>Li, Hai</creatorcontrib><creatorcontrib>Su, Chunxia</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Bin</au><au>Duan, Xiangguo</au><au>Zhou, Qiunan</au><au>Liu, Juanxi</au><au>Yang, Xiaojuan</au><au>Zhang, Dong</au><au>Yang, Shaoqi</au><au>Du, Yong</au><au>Li, Hai</au><au>Su, Chunxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of aspirin in the prevention of colorectal cancer through TIGIT‐CD155 pathway</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><addtitle>J Cell Mol Med</addtitle><date>2019-07</date><risdate>2019</risdate><volume>23</volume><issue>7</issue><spage>4514</spage><epage>4522</epage><pages>4514-4522</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>Colorectal cancer (CRC) is one of the most widespread malignant cancers, with a high incidence and mortality all over the world. Aspirin (ASA) otherwise known as acetylsalicylic acid, is a non‐steroidal anti‐inflammatory drug that has shown promising results in the prevention of chronic diseases, including several cancers. In previous studies, aspirin has been shown to reduce the incidence of CRC. Immune checkpoint blockade of T cell Ig and ITIM domain receptor (TIGIT) alone or combined with other immune checkpoint blockades moleculars has gained impressive results in the treatment of the melanoma and glioblastoma. Here, we found that TIGIT and Poliovirus receptor (PVR, CD155) are expressed in tumour cells; the TIGIT and CD155 protein expression in cancer tissue has been found to be significantly higher than that in the precancerous tissue. T cell Ig and ITIM domain receptor and CD226 were expressed in the lymphocytes near the tumour tissue and the adjacent tissues. Aspirin has been found to inhibit cancer cell viability and promote CRC cell apoptosis.Similarly, aspirin has also been found to increase pro‐apoptotic protein Bax's expression. We found that the expression of TIGIT decreased with an increase in the concentration of aspirin and that the suppression of TIGIT can affect the effect of aspirin on cell proliferation. In this paper, we found that aspirin attenuates cancer cell proliferation and induces CRC cells apoptosis by down‐regulating the expression of TIGIT, which provides new evidence for the application of aspirin in cancer treatment.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>31090213</pmid><doi>10.1111/jcmm.14332</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9523-1973</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylsalicylic acid Alcohol Alzheimer's disease Antigens Antigens, Differentiation, T-Lymphocyte - metabolism Apoptosis Apoptosis - drug effects Aspirin Aspirin - pharmacology Aspirin - therapeutic use BAX protein bcl-2-Associated X Protein - metabolism Cancer Cancer therapies CD155 CD155 antigen CD226 Cell adhesion & migration Cell growth Cell Movement - drug effects Cell proliferation Cell Survival - drug effects Cell viability Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Disease prevention Flow cytometry Glioblastoma HT29 Cells Humans Immune checkpoint Immune system Immunoglobulins Incidence Inflammation Lymphocytes Lymphocytes - metabolism Lymphocytes T Medical prognosis Medical research Melanoma Original Proteins R&D Receptors, Immunologic - metabolism Receptors, Virus - metabolism Research & development Researchers Signal Transduction - drug effects T cell receptors TIGIT Tissues Tumors |
| title | Use of aspirin in the prevention of colorectal cancer through TIGIT‐CD155 pathway |
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