CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome

Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these associations, rs1015164A/G, is unknown. We found t...

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Veröffentlicht in:	Nature immunology 2019-07, Vol.20 (7), p.824-834
Hauptverfasser:	Kulkarni, Smita, Lied, Alexandra, Kulkarni, Viraj, Rucevic, Marijana, Martin, Maureen P., Walker-Sperling, Victoria, Anderson, Stephen K., Ewy, Rodger, Singh, Sukhvinder, Nguyen, Hoang, McLaren, Paul J., Viard, Mathias, Naranbhai, Vivek, Zou, Chengcheng, Lin, Zhansong, Gatanaga, Hiroyuki, Oka, Shinichi, Takiguchi, Masafumi, Thio, Chloe L., Margolick, Joseph, Kirk, Gregory D., Goedert, James J., Hoots, W. Keith, Deeks, Steven G., Haas, David W., Michael, Nelson, Walker, Bruce, Le Gall, Sylvie, Chowdhury, Fatema Z., Yu, Xu G., Carrington, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 631/250/2502 692/699/255/1901 Activating transcription factor 1 Alleles Analysis Antisense RNA Binding sites Biomarkers Biomedical and Life Sciences Biomedicine Care and treatment CCR5 protein CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell Membrane - metabolism Gene Expression Regulation Genes, Reporter Genetic aspects Genetic diversity Genetic variance Genetic Variation Genome-wide association studies Genomes Genotype HIV HIV infection HIV Infections - genetics HIV Infections - metabolism HIV Infections - virology HIV-1 Human immunodeficiency virus Humans Immunology Infections Infectious Diseases Linkage Disequilibrium Lymphocytes Lymphocytes T mRNA Polymorphism, Single Nucleotide Population Groups - genetics Prognosis Receptors, CCR5 - genetics Receptors, CCR5 - metabolism RNA Stability RNA, Antisense - genetics RNA, Long Noncoding - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA-binding protein Single nucleotide polymorphisms Viral Load
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