Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis

IMPORTANCE: Even though osteoarthritis is a chronic and progressive disease, pharmacological agents are mainly studied over short-term periods, resulting in unclear recommendations for long-term disease management. OBJECTIVE: To search, review, and analyze long-term (≥12 months) outcomes (symptoms,...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2018-12, Vol.320 (24), p.2564-2579
Hauptverfasser:	Gregori, Dario, Giacovelli, Giampaolo, Minto, Clara, Barbetta, Beatrice, Gualtieri, Francesca, Azzolina, Danila, Vaghi, Paola, Rovati, Lucio C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - therapeutic use Aged Analgesics Analgesics - therapeutic use Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Antioxidants Arthritis Bayesian analysis Biocompatibility Bisphosphonates Bone Density Conservation Agents - therapeutic use Celecoxib Celecoxib - therapeutic use Chondroitin sulfate Clinical trials Corticoids Corticosteroids Data processing Disease control Drug therapy Drugs Female Follow-Up Studies Glucosamine Glucosamine - therapeutic use Humans Hyaluronic acid Inflammation Injections, Intra-Articular Knee Male Medical research Meta-analysis Middle Aged Original Investigation Osteoarthritis Osteoarthritis, Knee - drug therapy Pain Pain management Pain Management - methods Patients Pharmacology Strontium Structure-function relationships Sulfates Systematic review Uncertainty
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