Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study
Purpose To assess the association between diabetes mellitus (DM) and the incidence of cancer at different sites. Methods Data from the baseline and first three follow-up visits of the Atherosclerosis Risk in Communities (ARIC) study, an ongoing cohort study of adults from four American communities,...
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| Veröffentlicht in: | Journal of diabetes and metabolic disorders 2019-06, Vol.18 (1), p.65-72 |
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| container_title | Journal of diabetes and metabolic disorders |
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| creator | Rastad, Hadith Parsaeian, Mahboubeh Shirzad, Nooshin Mansournia, Mohammad Ali Yazdani, Kamran |
| description | Purpose
To assess the association between diabetes mellitus (DM) and the incidence of cancer at different sites.
Methods
Data from the baseline and first three follow-up visits of the Atherosclerosis Risk in Communities (ARIC) study, an ongoing cohort study of adults from four American communities, were used in this study. Of 15,792 persons aged 45–64 years old who participated in the baseline visit, the data of 15,118 participants were available for this study. For each cancer site, a conditional stratified Poisson regression model was fitted to estimate the adjusted relative rate and 95% confidence interval (adj. RR, 95% CI) of its incidence in diabetics compared to non-diabetics.
Results
We excluded 850 participants with a history of cancer at baseline and 149 participants who developed cancer during 2 years after enrollment, leaving a total of 14,119 participants of whom 1721 were diabetics. Independent of age, body mass index, alcohol consumption, and physical activity, DM decreased the risk of all cancers combined (adj. RR: 0.77, 95% CI: 0.60, 0.98) and the risk of prostate cancer (adj. RR: 0.51, 95% CI: 0.27, 0.97) and increased the risk of colorectal cancer in non-menopausal women (adj. RR: 12.08, 95% CI: 2.06, 70.94).
Conclusions
In conclusion, DM may be associated with an increased risk of colorectal cancer in non-menopausal women and a decreased risk of prostate cancer and all cancers combined. |
| doi_str_mv | 10.1007/s40200-019-00391-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6582039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A586511992</galeid><sourcerecordid>A586511992</sourcerecordid><originalsourceid>FETCH-LOGICAL-c572t-c6abf9f075bac4cb0ab66901ec0003b3b4366515bc4fd92b4619f37c0cf20f783</originalsourceid><addsrcrecordid>eNp9kt1r1TAYxosobsz9A15IQJB50ZmPNmm9EA7Hr8FAGHodkjQ5zWyTmaTC_nvf45nbOSK2kITk9z7N-_SpqucEnxOMxZvcYIpxjUlfY8x6UrePqmNKW1LztiOP99ZH1WnO1xgeIbqO8KfVESNUtJ3gx5V575W2xWY022nyZclIhQEZFYxNyAfjBwvLt6iMFq1gSDGbaTv6jK58_g4MWsd5XoIvHmTOVlcX69fIxDGmgnJZhttn1ROnpmxP7-aT6tvHD1_Xn-vLL58u1qvL2rSCltpwpV3vsGi1Mo3RWGnOe0ysgaszzXTDOG9Jq03jhp7qhpPeMWGwcRQ70bGT6t1O92bRsx2MDSWpSd4kP6t0K6Py8vAk-FFu4k8JLlHwEATO7gRS_LHYXOTsswFfVLBxyRIsZRRQgQF9-Rd6HZcUoD2gGtpxBtMDtVGTlT64CN81W1G5ajtohvQ9Ber8HxS8g529icE6D_sHBa_2CkarpjLmOC3Fx5APQboDDfywnKy7N4NguY2R3MVIQozk7xjJFope7Nt4X_InNACwHZDhKGxseuj9P7K_ANda0LA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2242863224</pqid></control><display><type>article</type><title>Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study</title><source>SpringerLink Journals</source><source>PubMed Central</source><creator>Rastad, Hadith ; Parsaeian, Mahboubeh ; Shirzad, Nooshin ; Mansournia, Mohammad Ali ; Yazdani, Kamran</creator><creatorcontrib>Rastad, Hadith ; Parsaeian, Mahboubeh ; Shirzad, Nooshin ; Mansournia, Mohammad Ali ; Yazdani, Kamran</creatorcontrib><description>Purpose
To assess the association between diabetes mellitus (DM) and the incidence of cancer at different sites.
Methods
Data from the baseline and first three follow-up visits of the Atherosclerosis Risk in Communities (ARIC) study, an ongoing cohort study of adults from four American communities, were used in this study. Of 15,792 persons aged 45–64 years old who participated in the baseline visit, the data of 15,118 participants were available for this study. For each cancer site, a conditional stratified Poisson regression model was fitted to estimate the adjusted relative rate and 95% confidence interval (adj. RR, 95% CI) of its incidence in diabetics compared to non-diabetics.
Results
We excluded 850 participants with a history of cancer at baseline and 149 participants who developed cancer during 2 years after enrollment, leaving a total of 14,119 participants of whom 1721 were diabetics. Independent of age, body mass index, alcohol consumption, and physical activity, DM decreased the risk of all cancers combined (adj. RR: 0.77, 95% CI: 0.60, 0.98) and the risk of prostate cancer (adj. RR: 0.51, 95% CI: 0.27, 0.97) and increased the risk of colorectal cancer in non-menopausal women (adj. RR: 12.08, 95% CI: 2.06, 70.94).
Conclusions
In conclusion, DM may be associated with an increased risk of colorectal cancer in non-menopausal women and a decreased risk of prostate cancer and all cancers combined.</description><identifier>ISSN: 2251-6581</identifier><identifier>EISSN: 2251-6581</identifier><identifier>DOI: 10.1007/s40200-019-00391-5</identifier><identifier>PMID: 31275876</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Atherosclerosis ; Cancer ; Cancer research ; Cohort analysis ; Colorectal cancer ; Complications and side effects ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetics ; Drinking (Alcoholic beverages) ; Endocrinology ; Exercise ; Health risk assessment ; Medical research ; Medicine ; Medicine & Public Health ; Menopause ; Metabolic Diseases ; Patient outcomes ; Prostate cancer ; Research Article ; Risk factors</subject><ispartof>Journal of diabetes and metabolic disorders, 2019-06, Vol.18 (1), p.65-72</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>COPYRIGHT 2019 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-c6abf9f075bac4cb0ab66901ec0003b3b4366515bc4fd92b4619f37c0cf20f783</citedby><cites>FETCH-LOGICAL-c572t-c6abf9f075bac4cb0ab66901ec0003b3b4366515bc4fd92b4619f37c0cf20f783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582039/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582039/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,41467,42536,51297,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31275876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rastad, Hadith</creatorcontrib><creatorcontrib>Parsaeian, Mahboubeh</creatorcontrib><creatorcontrib>Shirzad, Nooshin</creatorcontrib><creatorcontrib>Mansournia, Mohammad Ali</creatorcontrib><creatorcontrib>Yazdani, Kamran</creatorcontrib><title>Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study</title><title>Journal of diabetes and metabolic disorders</title><addtitle>J Diabetes Metab Disord</addtitle><addtitle>J Diabetes Metab Disord</addtitle><description>Purpose
To assess the association between diabetes mellitus (DM) and the incidence of cancer at different sites.
Methods
Data from the baseline and first three follow-up visits of the Atherosclerosis Risk in Communities (ARIC) study, an ongoing cohort study of adults from four American communities, were used in this study. Of 15,792 persons aged 45–64 years old who participated in the baseline visit, the data of 15,118 participants were available for this study. For each cancer site, a conditional stratified Poisson regression model was fitted to estimate the adjusted relative rate and 95% confidence interval (adj. RR, 95% CI) of its incidence in diabetics compared to non-diabetics.
Results
We excluded 850 participants with a history of cancer at baseline and 149 participants who developed cancer during 2 years after enrollment, leaving a total of 14,119 participants of whom 1721 were diabetics. Independent of age, body mass index, alcohol consumption, and physical activity, DM decreased the risk of all cancers combined (adj. RR: 0.77, 95% CI: 0.60, 0.98) and the risk of prostate cancer (adj. RR: 0.51, 95% CI: 0.27, 0.97) and increased the risk of colorectal cancer in non-menopausal women (adj. RR: 12.08, 95% CI: 2.06, 70.94).
Conclusions
In conclusion, DM may be associated with an increased risk of colorectal cancer in non-menopausal women and a decreased risk of prostate cancer and all cancers combined.</description><subject>Atherosclerosis</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Cohort analysis</subject><subject>Colorectal cancer</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetics</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Endocrinology</subject><subject>Exercise</subject><subject>Health risk assessment</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Metabolic Diseases</subject><subject>Patient outcomes</subject><subject>Prostate cancer</subject><subject>Research Article</subject><subject>Risk factors</subject><issn>2251-6581</issn><issn>2251-6581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kt1r1TAYxosobsz9A15IQJB50ZmPNmm9EA7Hr8FAGHodkjQ5zWyTmaTC_nvf45nbOSK2kITk9z7N-_SpqucEnxOMxZvcYIpxjUlfY8x6UrePqmNKW1LztiOP99ZH1WnO1xgeIbqO8KfVESNUtJ3gx5V575W2xWY022nyZclIhQEZFYxNyAfjBwvLt6iMFq1gSDGbaTv6jK58_g4MWsd5XoIvHmTOVlcX69fIxDGmgnJZhttn1ROnpmxP7-aT6tvHD1_Xn-vLL58u1qvL2rSCltpwpV3vsGi1Mo3RWGnOe0ysgaszzXTDOG9Jq03jhp7qhpPeMWGwcRQ70bGT6t1O92bRsx2MDSWpSd4kP6t0K6Py8vAk-FFu4k8JLlHwEATO7gRS_LHYXOTsswFfVLBxyRIsZRRQgQF9-Rd6HZcUoD2gGtpxBtMDtVGTlT64CN81W1G5ajtohvQ9Ber8HxS8g529icE6D_sHBa_2CkarpjLmOC3Fx5APQboDDfywnKy7N4NguY2R3MVIQozk7xjJFope7Nt4X_InNACwHZDhKGxseuj9P7K_ANda0LA</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Rastad, Hadith</creator><creator>Parsaeian, Mahboubeh</creator><creator>Shirzad, Nooshin</creator><creator>Mansournia, Mohammad Ali</creator><creator>Yazdani, Kamran</creator><general>Springer International Publishing</general><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190601</creationdate><title>Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study</title><author>Rastad, Hadith ; Parsaeian, Mahboubeh ; Shirzad, Nooshin ; Mansournia, Mohammad Ali ; Yazdani, Kamran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-c6abf9f075bac4cb0ab66901ec0003b3b4366515bc4fd92b4619f37c0cf20f783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Atherosclerosis</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Cohort analysis</topic><topic>Colorectal cancer</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetics</topic><topic>Drinking (Alcoholic beverages)</topic><topic>Endocrinology</topic><topic>Exercise</topic><topic>Health risk assessment</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Metabolic Diseases</topic><topic>Patient outcomes</topic><topic>Prostate cancer</topic><topic>Research Article</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rastad, Hadith</creatorcontrib><creatorcontrib>Parsaeian, Mahboubeh</creatorcontrib><creatorcontrib>Shirzad, Nooshin</creatorcontrib><creatorcontrib>Mansournia, Mohammad Ali</creatorcontrib><creatorcontrib>Yazdani, Kamran</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of diabetes and metabolic disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rastad, Hadith</au><au>Parsaeian, Mahboubeh</au><au>Shirzad, Nooshin</au><au>Mansournia, Mohammad Ali</au><au>Yazdani, Kamran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study</atitle><jtitle>Journal of diabetes and metabolic disorders</jtitle><stitle>J Diabetes Metab Disord</stitle><addtitle>J Diabetes Metab Disord</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>18</volume><issue>1</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>2251-6581</issn><eissn>2251-6581</eissn><abstract>Purpose
To assess the association between diabetes mellitus (DM) and the incidence of cancer at different sites.
Methods
Data from the baseline and first three follow-up visits of the Atherosclerosis Risk in Communities (ARIC) study, an ongoing cohort study of adults from four American communities, were used in this study. Of 15,792 persons aged 45–64 years old who participated in the baseline visit, the data of 15,118 participants were available for this study. For each cancer site, a conditional stratified Poisson regression model was fitted to estimate the adjusted relative rate and 95% confidence interval (adj. RR, 95% CI) of its incidence in diabetics compared to non-diabetics.
Results
We excluded 850 participants with a history of cancer at baseline and 149 participants who developed cancer during 2 years after enrollment, leaving a total of 14,119 participants of whom 1721 were diabetics. Independent of age, body mass index, alcohol consumption, and physical activity, DM decreased the risk of all cancers combined (adj. RR: 0.77, 95% CI: 0.60, 0.98) and the risk of prostate cancer (adj. RR: 0.51, 95% CI: 0.27, 0.97) and increased the risk of colorectal cancer in non-menopausal women (adj. RR: 12.08, 95% CI: 2.06, 70.94).
Conclusions
In conclusion, DM may be associated with an increased risk of colorectal cancer in non-menopausal women and a decreased risk of prostate cancer and all cancers combined.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31275876</pmid><doi>10.1007/s40200-019-00391-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Atherosclerosis Cancer Cancer research Cohort analysis Colorectal cancer Complications and side effects Development and progression Diabetes Diabetes mellitus Diabetics Drinking (Alcoholic beverages) Endocrinology Exercise Health risk assessment Medical research Medicine Medicine & Public Health Menopause Metabolic Diseases Patient outcomes Prostate cancer Research Article Risk factors |
| title | Diabetes mellitus and cancer incidence: the Atherosclerosis Risk in Communities (ARIC) cohort study |
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