Microbiota and cancer immunotherapy: in search of microbial signals

Importantly, FMT in mice carrying tumours displayed improved response to anti-PDL-1 therapy when faeces originated from R compared to NR patients, suggesting a functional impact of microbiota in therapeutic responses. [...]microbial composition may possess predictive clinical value for immune checkpoint blockade therapy such as PD-1. Despite the divergence in 16S rDNA signals between studies, PD-1 responsiveness may be related to a common functionality from these disparate microorganisms. [...]the functional content of those samples was examined by aligning metagenome shotgun sequencing reads using Diamond aligner 21 to a local copy of KEGG bacterial orthologues22 Interestingly, using this approach a significant (p