microRNA‑421 promotes the progression of non‑small cell lung cancer by targeting HOPX and regulating the Wnt/β‑catenin signaling pathway

MicroRNAs (miRNAs) function as key regulators of numerous types of cancers. miRNA (miR)-421 expression is dysregulated in a variety of tumors; however, its role in non-small cell lung cancer (NSCLC) remains unclear. In the present study, the role and molecular mechanism of miR-421 in NSCLC was inves...

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Veröffentlicht in:	Molecular medicine reports 2019-05, Vol.20 (1), p.151-161
Hauptverfasser:	Liang, Huagang, Wang, Chao, Gao, Kun, Li, Jian, Jia, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bcl-2 protein Binding sites Biomarkers c-Myc protein Cancer therapies Carcinogenesis Caspase Caspase-3 Cell adhesion & migration Cell cycle Cell growth Cell migration Cell proliferation Cholecystokinin Cloning Cyclin D1 Ectopic expression Flow cytometry Gastric cancer Genes Lung cancer Medical prognosis Metastasis MicroRNAs miRNA Myc protein Non-small cell lung carcinoma Plasmids Poly(ADP-ribose) polymerase Polymerase chain reaction Protein expression Proteins RNA-directed DNA polymerase Roles Signal transduction Studies Thoracic surgery Tumors Wnt protein Xenografts β-Catenin
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