Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study
Objectives Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2019-07, Vol.34 (7), p.1041-1049 |
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| container_title | International journal of geriatric psychiatry |
| container_volume | 34 |
| creator | Perales‐Puchalt, Jaime Vidoni, Michelle L. Llibre Rodríguez, Juan Vidoni, Eric D. Billinger, Sandra Burns, Jeffrey Guerchet, Maëlenn Lee, MinJae |
| description | Objectives
Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries.
Methods
We analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death.
Results
The sample included 6.2% participants with poor (0‐5), 81.0% with moderate (6‐10), and 12.8% with ideal CVH (11‐14). At follow‐up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66).
Conclusion
Moderate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries. |
| doi_str_mv | 10.1002/gps.5107 |
| format | Article |
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Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries.
Methods
We analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death.
Results
The sample included 6.2% participants with poor (0‐5), 81.0% with moderate (6‐10), and 12.8% with ideal CVH (11‐14). At follow‐up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66).
Conclusion
Moderate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.5107</identifier><identifier>PMID: 30908765</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - epidemiology ; cardiovascular health ; competing risks ; Dementia ; Dementia - epidemiology ; Dementia - etiology ; Dementia disorders ; Female ; Geriatric psychiatry ; Health Promotion ; Health Status ; Hispanic or Latino ; Humans ; Incidence ; Latin America ; Latin America - epidemiology ; Life Sciences ; Longitudinal Studies ; Male ; Older people ; Regression Analysis ; Risk Factors ; Santé publique et épidémiologie ; survival analysis</subject><ispartof>International journal of geriatric psychiatry, 2019-07, Vol.34 (7), p.1041-1049</ispartof><rights>2019 John Wiley & Sons, Ltd.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4727-1e1a9e5a2e8f50a90079cb0be5ca113ca165a82affeaffdd0e152b7225b0c6653</citedby><cites>FETCH-LOGICAL-c4727-1e1a9e5a2e8f50a90079cb0be5ca113ca165a82affeaffdd0e152b7225b0c6653</cites><orcidid>0000-0001-5181-7131 ; 0000-0002-4329-506X ; 0000-0003-1013-7847 ; 0000-0002-9020-4394</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.5107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.5107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30908765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03517268$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Perales‐Puchalt, Jaime</creatorcontrib><creatorcontrib>Vidoni, Michelle L.</creatorcontrib><creatorcontrib>Llibre Rodríguez, Juan</creatorcontrib><creatorcontrib>Vidoni, Eric D.</creatorcontrib><creatorcontrib>Billinger, Sandra</creatorcontrib><creatorcontrib>Burns, Jeffrey</creatorcontrib><creatorcontrib>Guerchet, Maëlenn</creatorcontrib><creatorcontrib>Lee, MinJae</creatorcontrib><title>Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description>Objectives
Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries.
Methods
We analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death.
Results
The sample included 6.2% participants with poor (0‐5), 81.0% with moderate (6‐10), and 12.8% with ideal CVH (11‐14). At follow‐up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66).
Conclusion
Moderate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>cardiovascular health</subject><subject>competing risks</subject><subject>Dementia</subject><subject>Dementia - epidemiology</subject><subject>Dementia - etiology</subject><subject>Dementia disorders</subject><subject>Female</subject><subject>Geriatric psychiatry</subject><subject>Health Promotion</subject><subject>Health Status</subject><subject>Hispanic or Latino</subject><subject>Humans</subject><subject>Incidence</subject><subject>Latin America</subject><subject>Latin America - epidemiology</subject><subject>Life Sciences</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Older people</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Santé publique et épidémiologie</subject><subject>survival analysis</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9r2zAUxc3YWNNusE8wBHtZH9xeyZEs76EQwtYOAhv78yyupevExbYyyc7It5_SdKUr7EFXoPPTubo6WfaGwwUHEJfrbbyQHMpn2YxDVeWcK_U8m4HWMleigJPsNMZbgKRx_TI7KaACXSo5y4YlBtf6HUY7dRjYhrAbNwwHxxz1NIwtsnawraPBEsPeD2vmO0eBoZu6MSaRrXBMddFTaC1-YN8o3ilN8D0bN8Q4XCrF4ji5_avsRYNdpNf3-1n289PHH8ubfPXl-vNyscrtvBRlzoljRRIF6UYCVgBlZWuoSVrkvEhFSdQCm4bScg6IS1GXQsgarFKyOMuujr7bqe7J2TRIwM5sQ9tj2BuPrflXGdqNWfudUbKsFFfJ4PxosHly7WaxMoczKCQvhdI7ntj3982C_zVRHE3fRktdhwP5KRrBq1JrPYcioe-eoLd-CkP6CiPEnBe60OUjQxt8jIGahxdwMIfATQrcHAJP6NvHgz6AfxNOQH4Efrcd7f9rZK6_fr8z_AMWFrSN</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Perales‐Puchalt, Jaime</creator><creator>Vidoni, Michelle L.</creator><creator>Llibre Rodríguez, Juan</creator><creator>Vidoni, Eric D.</creator><creator>Billinger, Sandra</creator><creator>Burns, Jeffrey</creator><creator>Guerchet, Maëlenn</creator><creator>Lee, MinJae</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5181-7131</orcidid><orcidid>https://orcid.org/0000-0002-4329-506X</orcidid><orcidid>https://orcid.org/0000-0003-1013-7847</orcidid><orcidid>https://orcid.org/0000-0002-9020-4394</orcidid></search><sort><creationdate>201907</creationdate><title>Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study</title><author>Perales‐Puchalt, Jaime ; Vidoni, Michelle L. ; Llibre Rodríguez, Juan ; Vidoni, Eric D. ; Billinger, Sandra ; Burns, Jeffrey ; Guerchet, Maëlenn ; Lee, MinJae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4727-1e1a9e5a2e8f50a90079cb0be5ca113ca165a82affeaffdd0e152b7225b0c6653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>cardiovascular health</topic><topic>competing risks</topic><topic>Dementia</topic><topic>Dementia - epidemiology</topic><topic>Dementia - etiology</topic><topic>Dementia disorders</topic><topic>Female</topic><topic>Geriatric psychiatry</topic><topic>Health Promotion</topic><topic>Health Status</topic><topic>Hispanic or Latino</topic><topic>Humans</topic><topic>Incidence</topic><topic>Latin America</topic><topic>Latin America - epidemiology</topic><topic>Life Sciences</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Older people</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Santé publique et épidémiologie</topic><topic>survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perales‐Puchalt, Jaime</creatorcontrib><creatorcontrib>Vidoni, Michelle L.</creatorcontrib><creatorcontrib>Llibre Rodríguez, Juan</creatorcontrib><creatorcontrib>Vidoni, Eric D.</creatorcontrib><creatorcontrib>Billinger, Sandra</creatorcontrib><creatorcontrib>Burns, Jeffrey</creatorcontrib><creatorcontrib>Guerchet, Maëlenn</creatorcontrib><creatorcontrib>Lee, MinJae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perales‐Puchalt, Jaime</au><au>Vidoni, Michelle L.</au><au>Llibre Rodríguez, Juan</au><au>Vidoni, Eric D.</au><au>Billinger, Sandra</au><au>Burns, Jeffrey</au><au>Guerchet, Maëlenn</au><au>Lee, MinJae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2019-07</date><risdate>2019</risdate><volume>34</volume><issue>7</issue><spage>1041</spage><epage>1049</epage><pages>1041-1049</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract>Objectives
Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries.
Methods
We analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death.
Results
The sample included 6.2% participants with poor (0‐5), 81.0% with moderate (6‐10), and 12.8% with ideal CVH (11‐14). At follow‐up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66).
Conclusion
Moderate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30908765</pmid><doi>10.1002/gps.5107</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5181-7131</orcidid><orcidid>https://orcid.org/0000-0002-4329-506X</orcidid><orcidid>https://orcid.org/0000-0003-1013-7847</orcidid><orcidid>https://orcid.org/0000-0002-9020-4394</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of geriatric psychiatry, 2019-07, Vol.34 (7), p.1041-1049 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Aged Aged, 80 and over Cardiovascular Diseases - complications Cardiovascular Diseases - epidemiology cardiovascular health competing risks Dementia Dementia - epidemiology Dementia - etiology Dementia disorders Female Geriatric psychiatry Health Promotion Health Status Hispanic or Latino Humans Incidence Latin America Latin America - epidemiology Life Sciences Longitudinal Studies Male Older people Regression Analysis Risk Factors Santé publique et épidémiologie survival analysis |
| title | Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study |
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