Functional Analysis of Dynactin and Cytoplasmic Dynein in Slow Axonal Transport

The neuron moves protein and membrane from the cell body to the synapse and back via fast and slow axonal transport. Little is known about the mechanism of microtubule movement in slow axonal transport, although cytoplasmic dynein, the motor for retrograde fast axonal transport of membranous organel...

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Veröffentlicht in:	The Journal of neuroscience 1996-11, Vol.16 (21), p.6742-6752
Hauptverfasser:	Dillman III, James F, Dabney, Lewis P, Karki, Sher, Paschal, Bryce M, Holzbaur, Erika L. F, Pfister, K. Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - metabolism Animals Axonal Transport - physiology Axons - chemistry Axons - physiology Cross-Linking Reagents Cytoplasm - chemistry Dynactin Complex Dyneins - analysis Dyneins - chemistry Dyneins - metabolism Isomerism Male Microtubule Proteins - analysis Microtubule Proteins - chemistry Microtubule Proteins - metabolism Microtubule-Associated Proteins - metabolism Microtubules - metabolism Rats Rats, Sprague-Dawley
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