DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs

Transcriptome analysis reveals a strong positive correlation between human Schlafen family member 11 (SLFN11) expression and the sensitivity of tumor cells to DNA-damaging agents (DDAs). Here, we show that SLFN11 preferentially inhibits translation of the serine/threonine kinases ATR and ATM upon DD...

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Veröffentlicht in:	Nature structural & molecular biology 2018-11, Vol.25 (11), p.1047-1058
Hauptverfasser:	Li, Manqing, Kao, Elaine, Malone, Dane, Gao, Xia, Wang, Jean Y. J., David, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/51 38/70 38/71 38/77 42/109 631/67 692/699/67 96/1 96/95 Ablation Amino acids Ataxia Telangiectasia Mutated Proteins - biosynthesis Ataxia Telangiectasia Mutated Proteins - genetics ATR protein Attenuation Biochemistry Biological Microscopy Biomedical and Life Sciences Camptothecin - pharmacology Cancer Cancer cells Cell death Cell Death - drug effects Cell Death - genetics Cell Death - physiology Cell Line, Tumor Cleavage Coding Codon - genetics Codons Correlation analysis Damage Deoxyribonucleic acid Displays (Marketing) DNA DNA Damage DNA repair Family Gene expression Genes Genetic aspects HEK293 Cells HIV infections Humans Kinases Leucine Life Sciences Membrane Biology Novels Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Biosynthesis - drug effects Protein Structure Proteins RNA RNA, Small Interfering - genetics RNA, Transfer - classification RNA, Transfer - genetics RNA, Transfer - metabolism RNA, Transfer, Leu - genetics RNA, Transfer, Leu - metabolism Sensitivity Serine Threonine Topoisomerase I Inhibitors - pharmacology Transfer RNA Translation tRNA Leu Tumor cells Tumors
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