Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus

Neonatal, bilateral lesion of the ventral hippocampus (VH) in rats recently has been proposed as a model of schizophrenia because these animals show postpubertal hypersensitivity to stress and to dopamine (DA) agonists that can be reversed by neuroleptic treatment. In search of the mechanisms of pos...

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Veröffentlicht in:	The Journal of neuroscience 1996-03, Vol.16 (6), p.2020-2026
Hauptverfasser:	Flores, G, Barbeau, D, Quirion, R, Srivastava, LK
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Autoradiography Behavior, Animal - physiology Benzazepines - metabolism Benzazepines - pharmacology Disease Models, Animal Dopamine Agonists - metabolism Dopamine Agonists - pharmacology Female Hippocampus - chemistry Hippocampus - surgery Limbic System - chemistry Limbic System - metabolism Nucleus Accumbens - chemistry Nucleus Accumbens - cytology Pregnancy Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 Schizophrenia - metabolism Spiperone - metabolism Spiperone - pharmacology Tetrahydronaphthalenes - metabolism Tetrahydronaphthalenes - pharmacology Tritium
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