Regulated secretion of beta-amyloid precursor protein in rat brain

The beta-amyloid precursor protein (APP) is a ubiquitous, highly conserved secretory glycoprotein that is expressed at high levels in mammalian brain by neurons, astrocytes, and activated microglia. Secreted APP (APPs) is generated by the cleavage of APP within the beta-amyloid (A beta) portion of i...

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Veröffentlicht in:	The Journal of neuroscience 1995-11, Vol.15 (11), p.7442-7451
Hauptverfasser:	Farber, SA, Nitsch, RM, Schulz, JG, Wurtman, RJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor - metabolism Animals Brain - metabolism Brain - physiology Electric Stimulation In Vitro Techniques Inositol Phosphates - metabolism Nerve Tissue Proteins - metabolism Neurotransmitter Agents - metabolism Rats Rats, Sprague-Dawley Receptors, Muscarinic - physiology
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