Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons
In insects, the neuropeptide eclosion hormone (EH) acts on the CNS to evoke the stereotyped behaviors that cause ecdysis, the shedding of the cuticle at the end of each molt. Concomitantly, EH induces an increase in cyclic GMP (cGMP). Using antibodies against this second messenger, we show that this...
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| Veröffentlicht in: | The Journal of neuroscience 1994-12, Vol.14 (12), p.7704-7712 |
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| container_title | The Journal of neuroscience |
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| creator | Ewer, J De Vente, J Truman, JW |
| description | In insects, the neuropeptide eclosion hormone (EH) acts on the CNS to evoke the stereotyped behaviors that cause ecdysis, the shedding of the cuticle at the end of each molt. Concomitantly, EH induces an increase in cyclic GMP (cGMP). Using antibodies against this second messenger, we show that this increase is confined to a network of 50 peptidergic neurons distributed throughout the CNS. Increases appeared 30 min after EH treatment, spread rapidly throughout these neurons, and were extremely long lived. We show that this response is synaptically driven, and does not involve the soluble, nitric oxide (NO)-activated, guanylate cyclase. Stereotyped variations in the duration of the cGMP response among neurons suggest a role in coordinating responses having different latencies and durations. |
| doi_str_mv | 10.1523/jneurosci.14-12-07704.1994 |
| format | Article |
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Concomitantly, EH induces an increase in cyclic GMP (cGMP). Using antibodies against this second messenger, we show that this increase is confined to a network of 50 peptidergic neurons distributed throughout the CNS. Increases appeared 30 min after EH treatment, spread rapidly throughout these neurons, and were extremely long lived. We show that this response is synaptically driven, and does not involve the soluble, nitric oxide (NO)-activated, guanylate cyclase. Stereotyped variations in the duration of the cGMP response among neurons suggest a role in coordinating responses having different latencies and durations.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/jneurosci.14-12-07704.1994</identifier><identifier>PMID: 7996205</identifier><language>eng</language><publisher>United States: Soc Neuroscience</publisher><subject>Animals ; Central Nervous System - cytology ; Central Nervous System - metabolism ; Cyclic GMP - metabolism ; Enzyme Activation ; Guanylate Cyclase - metabolism ; Immunohistochemistry ; Insect Hormones - pharmacology ; Manduca - metabolism ; Neurons - metabolism ; Synapses - physiology ; Time Factors</subject><ispartof>The Journal of neuroscience, 1994-12, Vol.14 (12), p.7704-7712</ispartof><rights>1994 by Society for Neuroscience 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-1979fcba1880e228e880a8e7e70f55a80eca8975cdb18a4f9326d3fe8c2e98f93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576893/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6576893/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7996205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ewer, J</creatorcontrib><creatorcontrib>De Vente, J</creatorcontrib><creatorcontrib>Truman, JW</creatorcontrib><title>Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>In insects, the neuropeptide eclosion hormone (EH) acts on the CNS to evoke the stereotyped behaviors that cause ecdysis, the shedding of the cuticle at the end of each molt. 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Stereotyped variations in the duration of the cGMP response among neurons suggest a role in coordinating responses having different latencies and durations.</description><subject>Animals</subject><subject>Central Nervous System - cytology</subject><subject>Central Nervous System - metabolism</subject><subject>Cyclic GMP - metabolism</subject><subject>Enzyme Activation</subject><subject>Guanylate Cyclase - metabolism</subject><subject>Immunohistochemistry</subject><subject>Insect Hormones - pharmacology</subject><subject>Manduca - metabolism</subject><subject>Neurons - metabolism</subject><subject>Synapses - physiology</subject><subject>Time Factors</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctOwzAQRS0EglL4BKSIBaxSbOdhmwUSqngUQUE81pbrTFojNyl2QuHvcdoKwWrsuXfOjHQROiZ4QDKanL1X0LraazMgaUxojBnD6YAIkW6hXnCImKaYbKMepgzHecrSPbTv_TvGmGHCdtEuEyKnOOuhr3GHWsCiMQVEpipa3Zi6iuoy0t_aGh3dPDyFvnagPPjwippZZ_Sgm2g4fjmPHPjatqsp1axUC59gO4Q31dQGdwFVY0qjJuGzur3yB2inVNbD4ab20dv11evwNr5_vBkNL-9jnRHRxEQwUeqJIpxjoJRDqIoDA4bLLFOhqRUXLNPFhHCVliKheZGUwDUFwcO3jy7W3EU7mUOhwyVOWblwZq7ct6yVkf-VyszktP6UecZyLpIAONkAXP3Rgm_k3HgN1qoK6tbL4OIE827T-dqoQzbeQfm7hGDZ5Sbvxldvz48vw5EkqSRUrnKTXW5h-Ojvmb-jm6CCfrrWZ2Y6WxoH0s-VtcFN5HK5XPM6XPIDqz6nUw</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Ewer, J</creator><creator>De Vente, J</creator><creator>Truman, JW</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19941201</creationdate><title>Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons</title><author>Ewer, J ; De Vente, J ; Truman, JW</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-1979fcba1880e228e880a8e7e70f55a80eca8975cdb18a4f9326d3fe8c2e98f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Central Nervous System - cytology</topic><topic>Central Nervous System - metabolism</topic><topic>Cyclic GMP - metabolism</topic><topic>Enzyme Activation</topic><topic>Guanylate Cyclase - metabolism</topic><topic>Immunohistochemistry</topic><topic>Insect Hormones - pharmacology</topic><topic>Manduca - metabolism</topic><topic>Neurons - metabolism</topic><topic>Synapses - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ewer, J</creatorcontrib><creatorcontrib>De Vente, J</creatorcontrib><creatorcontrib>Truman, JW</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ewer, J</au><au>De Vente, J</au><au>Truman, JW</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>14</volume><issue>12</issue><spage>7704</spage><epage>7712</epage><pages>7704-7712</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>In insects, the neuropeptide eclosion hormone (EH) acts on the CNS to evoke the stereotyped behaviors that cause ecdysis, the shedding of the cuticle at the end of each molt. 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| ispartof | The Journal of neuroscience, 1994-12, Vol.14 (12), p.7704-7712 |
| issn | 0270-6474 1529-2401 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Central Nervous System - cytology Central Nervous System - metabolism Cyclic GMP - metabolism Enzyme Activation Guanylate Cyclase - metabolism Immunohistochemistry Insect Hormones - pharmacology Manduca - metabolism Neurons - metabolism Synapses - physiology Time Factors |
| title | Neuropeptide induction of cyclic GMP increases in the insect CNS: resolution at the level of single identifiable neurons |
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