Germline-restricted chromosome (GRC) is widespread among songbirds
An unusual supernumerary chromosome has been reported for two related avian species, the zebra and Bengalese finches. This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. Its origin, distribution among avian lineages, and...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2019-06, Vol.116 (24), p.11845-11850 |
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| creator | Torgasheva, Anna A. Malinovskaya, Lyubov P. Zadesenets, Kira S. Karamysheva, Tatyana V. Kizilova, Elena A. Akberdina, Ekaterina A. Pristyazhnyuk, Inna E. Shnaider, Elena P. Volodkina, Valeria A. Saifitdinova, Alsu F. Galkina, Svetlana A. Larkin, Denis M. Rubtsov, Nikolai B. Borodin, Pavel M. |
| description | An unusual supernumerary chromosome has been reported for two related avian species, the zebra and Bengalese finches. This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. Its origin, distribution among avian lineages, and function were mostly unknown so far. Using immunolocalization of key meiotic proteins, we found that GRCs of varying size and genetic content are present in all 16 songbird species investigated and absent from germline genomes of all eight examined bird species from other avian orders. Results of fluorescent in situ hybridization of microdissected GRC probes and their sequencing indicate that GRCs show little homology between songbird species and contain a variety of repetitive elements and unique sequences with paralogs in the somatic genome. Our data suggest that the GRC evolved in the common ancestor of all songbirds and underwent significant changes in the extant descendant lineages. |
| doi_str_mv | 10.1073/pnas.1817373116 |
| format | Article |
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This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. Its origin, distribution among avian lineages, and function were mostly unknown so far. Using immunolocalization of key meiotic proteins, we found that GRCs of varying size and genetic content are present in all 16 songbird species investigated and absent from germline genomes of all eight examined bird species from other avian orders. Results of fluorescent in situ hybridization of microdissected GRC probes and their sequencing indicate that GRCs show little homology between songbird species and contain a variety of repetitive elements and unique sequences with paralogs in the somatic genome. Our data suggest that the GRC evolved in the common ancestor of all songbirds and underwent significant changes in the extant descendant lineages.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1817373116</identifier><identifier>PMID: 31036668</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; Biological Sciences ; Birds ; Chromosomes ; Chromosomes - genetics ; DNA probes ; Female ; Fluorescence ; Fluorescence in situ hybridization ; Gametocytes ; Gene sequencing ; Genome - genetics ; Genomes ; Genomics - methods ; Germ Cells - physiology ; Homology ; In Situ Hybridization, Fluorescence - methods ; Male ; Meiosis ; Oocytes ; Oocytes - physiology ; Passeri ; Repetitive Sequences, Nucleic Acid - genetics ; Somatic cells ; Songbirds ; Songbirds - genetics ; Species ; Spermatids ; Supernumerary</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (24), p.11845-11850</ispartof><rights>Copyright National Academy of Sciences Jun 11, 2019</rights><rights>2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-90853b7b6fdf55c9f2baa0c1a7dc1ce028f14cf21a51de72558d7d4ed560801e3</citedby><cites>FETCH-LOGICAL-c443t-90853b7b6fdf55c9f2baa0c1a7dc1ce028f14cf21a51de72558d7d4ed560801e3</cites><orcidid>0000-0002-6717-844X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26743492$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26743492$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31036668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torgasheva, Anna A.</creatorcontrib><creatorcontrib>Malinovskaya, Lyubov P.</creatorcontrib><creatorcontrib>Zadesenets, Kira S.</creatorcontrib><creatorcontrib>Karamysheva, Tatyana V.</creatorcontrib><creatorcontrib>Kizilova, Elena A.</creatorcontrib><creatorcontrib>Akberdina, Ekaterina A.</creatorcontrib><creatorcontrib>Pristyazhnyuk, Inna E.</creatorcontrib><creatorcontrib>Shnaider, Elena P.</creatorcontrib><creatorcontrib>Volodkina, Valeria A.</creatorcontrib><creatorcontrib>Saifitdinova, Alsu F.</creatorcontrib><creatorcontrib>Galkina, Svetlana A.</creatorcontrib><creatorcontrib>Larkin, Denis M.</creatorcontrib><creatorcontrib>Rubtsov, Nikolai B.</creatorcontrib><creatorcontrib>Borodin, Pavel M.</creatorcontrib><title>Germline-restricted chromosome (GRC) is widespread among songbirds</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>An unusual supernumerary chromosome has been reported for two related avian species, the zebra and Bengalese finches. This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. Its origin, distribution among avian lineages, and function were mostly unknown so far. Using immunolocalization of key meiotic proteins, we found that GRCs of varying size and genetic content are present in all 16 songbird species investigated and absent from germline genomes of all eight examined bird species from other avian orders. Results of fluorescent in situ hybridization of microdissected GRC probes and their sequencing indicate that GRCs show little homology between songbird species and contain a variety of repetitive elements and unique sequences with paralogs in the somatic genome. Our data suggest that the GRC evolved in the common ancestor of all songbirds and underwent significant changes in the extant descendant lineages.</description><subject>Animals</subject><subject>Biological Sciences</subject><subject>Birds</subject><subject>Chromosomes</subject><subject>Chromosomes - genetics</subject><subject>DNA probes</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Fluorescence in situ hybridization</subject><subject>Gametocytes</subject><subject>Gene sequencing</subject><subject>Genome - genetics</subject><subject>Genomes</subject><subject>Genomics - methods</subject><subject>Germ Cells - physiology</subject><subject>Homology</subject><subject>In Situ Hybridization, Fluorescence - methods</subject><subject>Male</subject><subject>Meiosis</subject><subject>Oocytes</subject><subject>Oocytes - physiology</subject><subject>Passeri</subject><subject>Repetitive Sequences, Nucleic Acid - genetics</subject><subject>Somatic cells</subject><subject>Songbirds</subject><subject>Songbirds - genetics</subject><subject>Species</subject><subject>Spermatids</subject><subject>Supernumerary</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1rFEEQxRtRzBo9e1IGvMTDJFX9PZeAWXQVAoLouenp7kl6mZleu2eV_Pd22Lh-XKoO71ePejxCXiKcIyh2sZttOUeNiimGKB-RFUKHreQdPCYrAKpazSk_Ic9K2QJAJzQ8JScMgUkp9YpcbUKexjiHNoey5OiW4Bt3m9OUSppCc7b5sn7bxNL8jD6UXQ7WN3ZK801T6uhj9uU5eTLYsYQXD_uUfPvw_uv6Y3v9efNp_e66dZyzpe1AC9arXg5-EMJ1A-2tBYdWeYcuANUDcjdQtAJ9UFQI7ZXnwQsJGjCwU3J58N3t-yl4F-Yl29HscpxsvjPJRvOvMsdbc5N-GClUNVPV4OzBIKfv-xrXTLG4MI52DmlfDKWouOwo7Sr65j90m_Z5rvEqxYUUqDVU6uJAuZxKyWE4PoNg7vsx9_2YP_3Ui9d_ZzjyvwupwKsDsC1LykedSsUZ7yj7BdQDliE</recordid><startdate>20190611</startdate><enddate>20190611</enddate><creator>Torgasheva, Anna A.</creator><creator>Malinovskaya, Lyubov P.</creator><creator>Zadesenets, Kira S.</creator><creator>Karamysheva, Tatyana V.</creator><creator>Kizilova, Elena A.</creator><creator>Akberdina, Ekaterina A.</creator><creator>Pristyazhnyuk, Inna E.</creator><creator>Shnaider, Elena P.</creator><creator>Volodkina, Valeria A.</creator><creator>Saifitdinova, Alsu F.</creator><creator>Galkina, Svetlana A.</creator><creator>Larkin, Denis M.</creator><creator>Rubtsov, Nikolai B.</creator><creator>Borodin, Pavel M.</creator><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6717-844X</orcidid></search><sort><creationdate>20190611</creationdate><title>Germline-restricted chromosome (GRC) is widespread among songbirds</title><author>Torgasheva, Anna A. ; 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This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. Its origin, distribution among avian lineages, and function were mostly unknown so far. Using immunolocalization of key meiotic proteins, we found that GRCs of varying size and genetic content are present in all 16 songbird species investigated and absent from germline genomes of all eight examined bird species from other avian orders. Results of fluorescent in situ hybridization of microdissected GRC probes and their sequencing indicate that GRCs show little homology between songbird species and contain a variety of repetitive elements and unique sequences with paralogs in the somatic genome. 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| subjects | Animals Biological Sciences Birds Chromosomes Chromosomes - genetics DNA probes Female Fluorescence Fluorescence in situ hybridization Gametocytes Gene sequencing Genome - genetics Genomes Genomics - methods Germ Cells - physiology Homology In Situ Hybridization, Fluorescence - methods Male Meiosis Oocytes Oocytes - physiology Passeri Repetitive Sequences, Nucleic Acid - genetics Somatic cells Songbirds Songbirds - genetics Species Spermatids Supernumerary |
| title | Germline-restricted chromosome (GRC) is widespread among songbirds |
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