Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b

Antigen binding by serum Ig-M (IgM) protects against microbial infections and helps to prevent autoimmunity, but causes life-threatening diseases when mistargeted. How antigen-bound IgM activates complement-immune responses remains unclear. We present cryoelectron tomography structures of IgM, C1, a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-06, Vol.116 (24), p.11900-11905
Hauptverfasser:	Sharp, Thomas H., Boyle, Aimee L., Diebolder, Christoph A., Kros, Alexander, Koster, Abraham J., Gros, Piet
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies - immunology Antigens Antigens - immunology Autoimmune diseases Autoimmunity Binding Sites - immunology Biological Sciences Collagen Complement Complement activation Complement Activation - immunology Complement C1 - immunology Complement C4 - immunology Complement component C1q Complement component C3 Domains Helices Hexamers Humans Immune response Immunoglobulin M Immunoglobulin M - immunology Lipid membranes Lipids Microorganisms Models, Molecular Surface antigens
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