Why haploinsufficiency persists

Haploinsufficiency describes the decrease in organismal fitness observed when a single copy of a gene is deleted in diploids. We investigated the origin of haploinsufficiency by creating a comprehensive dosage sensitivity data set for genes under their native promoters. We demonstrate that the expre...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-06, Vol.116 (24), p.11866-11871
Hauptverfasser:	Morrill, Summer A., Amon, Angelika
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell Survival - genetics Constraining Copy number Diploids Dosage Fitness Gene Dosage - genetics Gene expression Gene Expression - genetics Genes Genome - genetics Genomes Haploinsufficiency Haploinsufficiency - genetics Promoter Regions, Genetic - genetics Reproductive fitness Toxicity Yeasts - genetics
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