Regulation of alternative splicing by p300-mediated acetylation of splicing factors

Splicing of precursor mRNA (pre-mRNA) is an important regulatory step in gene expression. Recent evidence points to a regulatory role of chromatin-related proteins in alternative splicing regulation. Using an unbiased approach, we have identified the acetyltransferase p300 as a key chromatin-related...

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Veröffentlicht in:	RNA (Cambridge) 2019-07, Vol.25 (7), p.813-824
Hauptverfasser:	Siam, Ahmad, Baker, Mai, Amit, Leah, Regev, Gal, Rabner, Alona, Najar, Rauf Ahmad, Bentata, Mercedes, Dahan, Sara, Cohen, Klil, Araten, Sarah, Nevo, Yuval, Kay, Gillian, Mandel-Gutfreund, Yael, Salton, Maayan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Acetyltransferase Alternative Splicing Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology CD44 antigen Chromatin Chromatin - genetics Chromatin - metabolism E1A-Associated p300 Protein - genetics E1A-Associated p300 Protein - metabolism Event-related potentials Exons Female Gene expression Gene Expression Regulation, Neoplastic Genomes Humans Hyaluronan Receptors - genetics Hyaluronan Receptors - metabolism Promoter Regions, Genetic RNA Splicing Factors - chemistry RNA Splicing Factors - genetics RNA Splicing Factors - metabolism Splicing factors Transcription elongation Transcription, Genetic Tumor Cells, Cultured
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