Reduction of CuZn-Superoxide Dismutase Activity Exacerbates Neuronal Cell Injury and Edema Formation after Transient Focal Cerebral Ischemia

Apoptotic neuronal cell death has recently been associated with the development of infarction after cerebral ischemia. In a variety of studies, CuZn-superoxide dismutase (CuZn-SOD) has been shown to protect the brain from ischemic injury. A possible role for CuZn-SOD-related modulation of neuronal v...

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Veröffentlicht in:	The Journal of neuroscience 1997-06, Vol.17 (11), p.4180-4189
Hauptverfasser:	Kondo, Takeo, Reaume, Andrew G, Huang, Ting-Ting, Carlson, Elaine, Murakami, Kensuke, Chen, Sylvia F, Hoffman, Eric K, Scott, Richard W, Epstein, Charles J, Chan, Pak H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Biotin Blood-Brain Barrier - physiology Cell Death - physiology Cerebral Infarction - physiopathology Deoxyuracil Nucleotides DNA Fragmentation Edema - physiopathology Evans Blue - pharmacokinetics Ischemic Attack, Transient - enzymology Ischemic Attack, Transient - mortality Ischemic Attack, Transient - physiopathology Mice Mice, Mutant Strains Neurologic Examination Neurons - enzymology Neurons - pathology Oxidative Stress - physiology Prosencephalon - blood supply Prosencephalon - enzymology Prosencephalon - pathology Reactive Oxygen Species - physiology Staining and Labeling Superoxide Dismutase - genetics Superoxide Dismutase - metabolism
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