Endogenous Serine Protease Inhibitor Modulates Epileptic Activity and Hippocampal Long-Term Potentiation

Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1-/-) were found to develop epileptic...

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Veröffentlicht in:	The Journal of neuroscience 1997-06, Vol.17 (12), p.4688-4699
Hauptverfasser:	Luthi, Andreas, Putten, Herman van der, Botteri, Florence M, Mansuy, Isabelle M, Meins, Marita, Frey, Uwe, Sansig, Gilles, Portet, Chantal, Schmutz, Markus, Schroder, Markus, Nitsch, Cordula, Laurent, Jean-Paul, Monard, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Protein Precursor Animals Carrier Proteins - biosynthesis Carrier Proteins - genetics Carrier Proteins - physiology Epilepsy - genetics Epilepsy - physiopathology Hippocampus - physiology Hippocampus - physiopathology Kinetics Long-Term Potentiation Mice Mice, Knockout Mice, Neurologic Mutants Mice, Transgenic Neurons - physiology Promoter Regions, Genetic Protease Nexins Receptors, Cell Surface Recombinant Fusion Proteins - biosynthesis Serine Proteinase Inhibitors - genetics Serine Proteinase Inhibitors - physiology Synaptic Transmission Thy-1 Antigens - biosynthesis Thy-1 Antigens - genetics Time Factors
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