OCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons

Zone-to-zone projection of olfactory and vomeronasal sensory axons underlies the topographic and functional mapping of chemoreceptor expression zones of the sensory epithelia onto zonally arranged glomeruli in the main and accessory olfactory bulbs. Here we identified OCAM (R4B12 antigen), an axonal...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of neuroscience 1997-08, Vol.17 (15), p.5830-5842
Hauptverfasser: Yoshihara, Yoshihiro, Kawasaki, Miwa, Tamada, Atsushi, Fujita, Hiroko, Hayashi, Hideyuki, Kagamiyama, Hiroyuki, Mori, Kensaku
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 5842
container_issue 15
container_start_page 5830
container_title The Journal of neuroscience
container_volume 17
creator Yoshihara, Yoshihiro
Kawasaki, Miwa
Tamada, Atsushi
Fujita, Hiroko
Hayashi, Hideyuki
Kagamiyama, Hiroyuki
Mori, Kensaku
description Zone-to-zone projection of olfactory and vomeronasal sensory axons underlies the topographic and functional mapping of chemoreceptor expression zones of the sensory epithelia onto zonally arranged glomeruli in the main and accessory olfactory bulbs. Here we identified OCAM (R4B12 antigen), an axonal surface glycoprotein expressed by subsets of both olfactory and vomeronasal axons in a zone-specific manner. OCAM is a novel homophilic adhesion molecule belonging to the immunoglobulin superfamily with striking structural homology to neural cell adhesion molecule. In both the main and accessory olfactory systems, OCAM mRNA is expressed by sensory neurons in restricted chemoreceptor expression zones, and OCAM protein-expressing axons project to the glomeruli in the corresponding zones of the main and accessory bulbs. OCAM protein is expressed on subsets of growing sensory axons in explant cultures even in the absence of the target bulb. These results demonstrate a precisely coordinated zonal expression of chemoreceptors and OCAM and suggest that OCAM may play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
doi_str_mv 10.1523/jneurosci.17-15-05830.1997
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6573213</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16336486</sourcerecordid><originalsourceid>FETCH-LOGICAL-c550t-3bea35f91bd22cf6d4f93eb3025cc12a31b4c6f95b08c23711eada13d93f24683</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSMEKkPhEZAsFrBK8U8Sx10gRVFbijodVCgLNpbj3DQZOXGxE9LZ8-A4zKiCFasr3XPOJ1-fKHpD8AlJKXu_HWBy1uvuhPCYpDFOcxYkIfiTaBUcIqYJJk-jFaYcx1nCk-fRC--3GGOOCT-KjgSlhOdkFf3alMX6FBXoGma0hr4Ch2yDxhbCZnLKoBKMQUXdgu_sgNbWgJ4MoHPVd2aHbsCoEWo0WvTdDhCPNl4m-uzsFvS4RAJuYxqlR-t2SA01-mZ7cHZQPtCLBzv4l9GzRhkPrw7zOLo9P_tafoyvNheXZXEV6zTFY8wqUCxtBKlqSnWT1UkjGFQM01RrQhUjVaKzRqQVzjVlnBBQtSKsFqyhSZaz4-jDnns_VT3UGoYxXCjvXdcrt5NWdfJfZehaeWd_yizljBIWAG8PAGd_TOBH2Xdehw9SA9jJSy5IQhMq_mskGWNZkmfBeLo36lCod9A8voZguZQtP12f3d5svpSXkvCwkX_KlkvZIfz673seo4d2g_5ur7fdXTt3DqTvlTHBTeQ8z3vegmO_AcG2tvI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16336486</pqid></control><display><type>article</type><title>OCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Yoshihara, Yoshihiro ; Kawasaki, Miwa ; Tamada, Atsushi ; Fujita, Hiroko ; Hayashi, Hideyuki ; Kagamiyama, Hiroyuki ; Mori, Kensaku</creator><creatorcontrib>Yoshihara, Yoshihiro ; Kawasaki, Miwa ; Tamada, Atsushi ; Fujita, Hiroko ; Hayashi, Hideyuki ; Kagamiyama, Hiroyuki ; Mori, Kensaku</creatorcontrib><description>Zone-to-zone projection of olfactory and vomeronasal sensory axons underlies the topographic and functional mapping of chemoreceptor expression zones of the sensory epithelia onto zonally arranged glomeruli in the main and accessory olfactory bulbs. Here we identified OCAM (R4B12 antigen), an axonal surface glycoprotein expressed by subsets of both olfactory and vomeronasal axons in a zone-specific manner. OCAM is a novel homophilic adhesion molecule belonging to the immunoglobulin superfamily with striking structural homology to neural cell adhesion molecule. In both the main and accessory olfactory systems, OCAM mRNA is expressed by sensory neurons in restricted chemoreceptor expression zones, and OCAM protein-expressing axons project to the glomeruli in the corresponding zones of the main and accessory bulbs. OCAM protein is expressed on subsets of growing sensory axons in explant cultures even in the absence of the target bulb. These results demonstrate a precisely coordinated zonal expression of chemoreceptors and OCAM and suggest that OCAM may play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/jneurosci.17-15-05830.1997</identifier><identifier>PMID: 9221781</identifier><language>eng</language><publisher>United States: Soc Neuroscience</publisher><subject>Amino Acid Sequence ; Animals ; Axons - physiology ; Blotting, Northern ; Blotting, Western ; Cloning, Molecular ; Mice ; Molecular Sequence Data ; Neural Cell Adhesion Molecules - metabolism ; Olfactory Pathways - metabolism ; Vomeronasal Organ - metabolism</subject><ispartof>The Journal of neuroscience, 1997-08, Vol.17 (15), p.5830-5842</ispartof><rights>Copyright © 1997 Society for Neuroscience 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-3bea35f91bd22cf6d4f93eb3025cc12a31b4c6f95b08c23711eada13d93f24683</citedby><cites>FETCH-LOGICAL-c550t-3bea35f91bd22cf6d4f93eb3025cc12a31b4c6f95b08c23711eada13d93f24683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573213/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573213/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9221781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshihara, Yoshihiro</creatorcontrib><creatorcontrib>Kawasaki, Miwa</creatorcontrib><creatorcontrib>Tamada, Atsushi</creatorcontrib><creatorcontrib>Fujita, Hiroko</creatorcontrib><creatorcontrib>Hayashi, Hideyuki</creatorcontrib><creatorcontrib>Kagamiyama, Hiroyuki</creatorcontrib><creatorcontrib>Mori, Kensaku</creatorcontrib><title>OCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Zone-to-zone projection of olfactory and vomeronasal sensory axons underlies the topographic and functional mapping of chemoreceptor expression zones of the sensory epithelia onto zonally arranged glomeruli in the main and accessory olfactory bulbs. Here we identified OCAM (R4B12 antigen), an axonal surface glycoprotein expressed by subsets of both olfactory and vomeronasal axons in a zone-specific manner. OCAM is a novel homophilic adhesion molecule belonging to the immunoglobulin superfamily with striking structural homology to neural cell adhesion molecule. In both the main and accessory olfactory systems, OCAM mRNA is expressed by sensory neurons in restricted chemoreceptor expression zones, and OCAM protein-expressing axons project to the glomeruli in the corresponding zones of the main and accessory bulbs. OCAM protein is expressed on subsets of growing sensory axons in explant cultures even in the absence of the target bulb. These results demonstrate a precisely coordinated zonal expression of chemoreceptors and OCAM and suggest that OCAM may play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Axons - physiology</subject><subject>Blotting, Northern</subject><subject>Blotting, Western</subject><subject>Cloning, Molecular</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Neural Cell Adhesion Molecules - metabolism</subject><subject>Olfactory Pathways - metabolism</subject><subject>Vomeronasal Organ - metabolism</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhSMEKkPhEZAsFrBK8U8Sx10gRVFbijodVCgLNpbj3DQZOXGxE9LZ8-A4zKiCFasr3XPOJ1-fKHpD8AlJKXu_HWBy1uvuhPCYpDFOcxYkIfiTaBUcIqYJJk-jFaYcx1nCk-fRC--3GGOOCT-KjgSlhOdkFf3alMX6FBXoGma0hr4Ch2yDxhbCZnLKoBKMQUXdgu_sgNbWgJ4MoHPVd2aHbsCoEWo0WvTdDhCPNl4m-uzsFvS4RAJuYxqlR-t2SA01-mZ7cHZQPtCLBzv4l9GzRhkPrw7zOLo9P_tafoyvNheXZXEV6zTFY8wqUCxtBKlqSnWT1UkjGFQM01RrQhUjVaKzRqQVzjVlnBBQtSKsFqyhSZaz4-jDnns_VT3UGoYxXCjvXdcrt5NWdfJfZehaeWd_yizljBIWAG8PAGd_TOBH2Xdehw9SA9jJSy5IQhMq_mskGWNZkmfBeLo36lCod9A8voZguZQtP12f3d5svpSXkvCwkX_KlkvZIfz673seo4d2g_5ur7fdXTt3DqTvlTHBTeQ8z3vegmO_AcG2tvI</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Yoshihara, Yoshihiro</creator><creator>Kawasaki, Miwa</creator><creator>Tamada, Atsushi</creator><creator>Fujita, Hiroko</creator><creator>Hayashi, Hideyuki</creator><creator>Kagamiyama, Hiroyuki</creator><creator>Mori, Kensaku</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19970801</creationdate><title>OCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons</title><author>Yoshihara, Yoshihiro ; Kawasaki, Miwa ; Tamada, Atsushi ; Fujita, Hiroko ; Hayashi, Hideyuki ; Kagamiyama, Hiroyuki ; Mori, Kensaku</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-3bea35f91bd22cf6d4f93eb3025cc12a31b4c6f95b08c23711eada13d93f24683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Axons - physiology</topic><topic>Blotting, Northern</topic><topic>Blotting, Western</topic><topic>Cloning, Molecular</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Neural Cell Adhesion Molecules - metabolism</topic><topic>Olfactory Pathways - metabolism</topic><topic>Vomeronasal Organ - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshihara, Yoshihiro</creatorcontrib><creatorcontrib>Kawasaki, Miwa</creatorcontrib><creatorcontrib>Tamada, Atsushi</creatorcontrib><creatorcontrib>Fujita, Hiroko</creatorcontrib><creatorcontrib>Hayashi, Hideyuki</creatorcontrib><creatorcontrib>Kagamiyama, Hiroyuki</creatorcontrib><creatorcontrib>Mori, Kensaku</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshihara, Yoshihiro</au><au>Kawasaki, Miwa</au><au>Tamada, Atsushi</au><au>Fujita, Hiroko</au><au>Hayashi, Hideyuki</au><au>Kagamiyama, Hiroyuki</au><au>Mori, Kensaku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>17</volume><issue>15</issue><spage>5830</spage><epage>5842</epage><pages>5830-5842</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>Zone-to-zone projection of olfactory and vomeronasal sensory axons underlies the topographic and functional mapping of chemoreceptor expression zones of the sensory epithelia onto zonally arranged glomeruli in the main and accessory olfactory bulbs. Here we identified OCAM (R4B12 antigen), an axonal surface glycoprotein expressed by subsets of both olfactory and vomeronasal axons in a zone-specific manner. OCAM is a novel homophilic adhesion molecule belonging to the immunoglobulin superfamily with striking structural homology to neural cell adhesion molecule. In both the main and accessory olfactory systems, OCAM mRNA is expressed by sensory neurons in restricted chemoreceptor expression zones, and OCAM protein-expressing axons project to the glomeruli in the corresponding zones of the main and accessory bulbs. OCAM protein is expressed on subsets of growing sensory axons in explant cultures even in the absence of the target bulb. These results demonstrate a precisely coordinated zonal expression of chemoreceptors and OCAM and suggest that OCAM may play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.</abstract><cop>United States</cop><pub>Soc Neuroscience</pub><pmid>9221781</pmid><doi>10.1523/jneurosci.17-15-05830.1997</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0270-6474
ispartof The Journal of neuroscience, 1997-08, Vol.17 (15), p.5830-5842
issn 0270-6474
1529-2401
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6573213
source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Amino Acid Sequence
Animals
Axons - physiology
Blotting, Northern
Blotting, Western
Cloning, Molecular
Mice
Molecular Sequence Data
Neural Cell Adhesion Molecules - metabolism
Olfactory Pathways - metabolism
Vomeronasal Organ - metabolism
title OCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T12%3A37%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=OCAM:%20A%20New%20Member%20of%20the%20Neural%20Cell%20Adhesion%20Molecule%20Family%20Related%20to%20Zone-to-Zone%20Projection%20of%20Olfactory%20and%20Vomeronasal%20Axons&rft.jtitle=The%20Journal%20of%20neuroscience&rft.au=Yoshihara,%20Yoshihiro&rft.date=1997-08-01&rft.volume=17&rft.issue=15&rft.spage=5830&rft.epage=5842&rft.pages=5830-5842&rft.issn=0270-6474&rft.eissn=1529-2401&rft_id=info:doi/10.1523/jneurosci.17-15-05830.1997&rft_dat=%3Cproquest_pubme%3E16336486%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16336486&rft_id=info:pmid/9221781&rfr_iscdi=true