Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients
Liver and intestines are anatomically and physiologically linked. Zonulin is a protein modulating intercellular tight junctions and regulating intestinal permeability. Copeptin was studied as a marker of systemic circulation disorders in research about vasopressin and was associated with liver disea...
Gespeichert in:
| Veröffentlicht in: | Pakistan journal of medical sciences 2019-06, Vol.35 (3), p.847-851 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 851 |
|---|---|
| container_issue | 3 |
| container_start_page | 847 |
| container_title | Pakistan journal of medical sciences |
| container_volume | 35 |
| creator | Calgin, Mustafa Kerem Cetinkol, Yeliz |
| description | Liver and intestines are anatomically and physiologically linked. Zonulin is a protein modulating intercellular tight junctions and regulating intestinal permeability. Copeptin was studied as a marker of systemic circulation disorders in research about vasopressin and was associated with liver disease prognosis. Serum zonulin and copeptin levels were measured in patients with diagnosis of chronic hepatitis B (CHB) with the aim of easing antiviral treatment management in clinical applications and to investigate the association with normal population and viral load.
Analysis included the serum of 30 CHB patients and 17 controls. HBV-DNA real-time PCR tests were completed. CHB patients were divided into three subgroups according to viral load in serum. Zonulin and copeptin levels were measured using ELISA kits.
Serum zonulin and copeptin levels were significantly low in CHB patients compared to controls (p |
| doi_str_mv | 10.12669/pjms.35.3.144 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6572940</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A592340991</galeid><sourcerecordid>A592340991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-c99241c04a1a903d2dc80585449476f6eaf01900c07c05b95d2ab61fc2a526c43</originalsourceid><addsrcrecordid>eNptks9rFTEQx4MotlavHmVBEC-7TrJJdnMRav1RoehFobeQl53tyyObrMluQf9682qtrZQEMpP5zHeSYQh5TqGhTEr1Zt5NuWlF0zaU8wfkkMqe1h0V5w-vbFYD4-cH5EnOOwAuuWCPyUFLmegliEPy5T3ahCbjUHm8RJ-rOFYZ0zpVv2JYvQuVCUNl44zzUpyy7TbF4Gx1irNZ3OJy_a7aWxiW_JQ8Go3P-Oz6PCLfP374dnJan3399Pnk-Ky2vJNLbZVinFrghhoF7cAG24PoBeeqxEeJZgSqACx0FsRGiYGZjaSjZUYwaXl7RN7-0Z3XzYSDLbWT8XpObjLpp47G6buR4Lb6Il5qKTqmOBSB19cCKf5YMS96ctmi9yZgXLNmTIBk0EtZ0Jf_obu4plC-p1nL-64rje_-URfGo3ZhjKWu3YvqY6EKCErRQjX3UGUNODkbA46u3N9JeHUrYYvGL9sc_bq4GPK9yjbFnBOON82goK9GRe9HRbdCt7q8uCS8uN3CG_zvbLS_AVIKuFQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2348771447</pqid></control><display><type>article</type><title>Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Calgin, Mustafa Kerem ; Cetinkol, Yeliz</creator><creatorcontrib>Calgin, Mustafa Kerem ; Cetinkol, Yeliz</creatorcontrib><description>Liver and intestines are anatomically and physiologically linked. Zonulin is a protein modulating intercellular tight junctions and regulating intestinal permeability. Copeptin was studied as a marker of systemic circulation disorders in research about vasopressin and was associated with liver disease prognosis. Serum zonulin and copeptin levels were measured in patients with diagnosis of chronic hepatitis B (CHB) with the aim of easing antiviral treatment management in clinical applications and to investigate the association with normal population and viral load.
Analysis included the serum of 30 CHB patients and 17 controls. HBV-DNA real-time PCR tests were completed. CHB patients were divided into three subgroups according to viral load in serum. Zonulin and copeptin levels were measured using ELISA kits.
Serum zonulin and copeptin levels were significantly low in CHB patients compared to controls (p<0.001). When CHB subgroups are investigated in terms of serum zonulin and copeptin levels, there was an inverse correlation observed with significant difference (p<0.01, p<0.05).
The negative correlation between serum zonulin and copeptin with HBV-DNA load revealed in our study shows they may be used to monitor treatment. Zonulin and copeptin assays provide the possibility of developing new approaches to CHB diagnosis and monitoring.</description><identifier>ISSN: 1682-024X</identifier><identifier>EISSN: 1681-715X</identifier><identifier>DOI: 10.12669/pjms.35.3.144</identifier><identifier>PMID: 31258605</identifier><language>eng</language><publisher>Pakistan: Knowledge Bylanes</publisher><subject>Age ; Bacterial infections ; Carcinoma ; Care and treatment ; Chronic illnesses ; Deoxyribonucleic acid ; Development and progression ; DNA ; Health aspects ; Hepatitis ; Hepatitis B ; Hepatitis B virus ; Hepatocellular carcinoma ; Infection ; Infections ; Liver cirrhosis ; Liver diseases ; Microbiota ; Nervous system ; Original ; Patients ; Permeability ; Public health ; Small intestine ; Studies ; Variance analysis</subject><ispartof>Pakistan journal of medical sciences, 2019-06, Vol.35 (3), p.847-851</ispartof><rights>COPYRIGHT 2019 Knowledge Bylanes</rights><rights>(c)2019 Pakistan Journal of Medical Sciences</rights><rights>Copyright: © Pakistan Journal of Medical Sciences 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-c99241c04a1a903d2dc80585449476f6eaf01900c07c05b95d2ab61fc2a526c43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572940/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572940/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31258605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calgin, Mustafa Kerem</creatorcontrib><creatorcontrib>Cetinkol, Yeliz</creatorcontrib><title>Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients</title><title>Pakistan journal of medical sciences</title><addtitle>Pak J Med Sci</addtitle><description>Liver and intestines are anatomically and physiologically linked. Zonulin is a protein modulating intercellular tight junctions and regulating intestinal permeability. Copeptin was studied as a marker of systemic circulation disorders in research about vasopressin and was associated with liver disease prognosis. Serum zonulin and copeptin levels were measured in patients with diagnosis of chronic hepatitis B (CHB) with the aim of easing antiviral treatment management in clinical applications and to investigate the association with normal population and viral load.
Analysis included the serum of 30 CHB patients and 17 controls. HBV-DNA real-time PCR tests were completed. CHB patients were divided into three subgroups according to viral load in serum. Zonulin and copeptin levels were measured using ELISA kits.
Serum zonulin and copeptin levels were significantly low in CHB patients compared to controls (p<0.001). When CHB subgroups are investigated in terms of serum zonulin and copeptin levels, there was an inverse correlation observed with significant difference (p<0.01, p<0.05).
The negative correlation between serum zonulin and copeptin with HBV-DNA load revealed in our study shows they may be used to monitor treatment. Zonulin and copeptin assays provide the possibility of developing new approaches to CHB diagnosis and monitoring.</description><subject>Age</subject><subject>Bacterial infections</subject><subject>Carcinoma</subject><subject>Care and treatment</subject><subject>Chronic illnesses</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B virus</subject><subject>Hepatocellular carcinoma</subject><subject>Infection</subject><subject>Infections</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Microbiota</subject><subject>Nervous system</subject><subject>Original</subject><subject>Patients</subject><subject>Permeability</subject><subject>Public health</subject><subject>Small intestine</subject><subject>Studies</subject><subject>Variance analysis</subject><issn>1682-024X</issn><issn>1681-715X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptks9rFTEQx4MotlavHmVBEC-7TrJJdnMRav1RoehFobeQl53tyyObrMluQf9682qtrZQEMpP5zHeSYQh5TqGhTEr1Zt5NuWlF0zaU8wfkkMqe1h0V5w-vbFYD4-cH5EnOOwAuuWCPyUFLmegliEPy5T3ahCbjUHm8RJ-rOFYZ0zpVv2JYvQuVCUNl44zzUpyy7TbF4Gx1irNZ3OJy_a7aWxiW_JQ8Go3P-Oz6PCLfP374dnJan3399Pnk-Ky2vJNLbZVinFrghhoF7cAG24PoBeeqxEeJZgSqACx0FsRGiYGZjaSjZUYwaXl7RN7-0Z3XzYSDLbWT8XpObjLpp47G6buR4Lb6Il5qKTqmOBSB19cCKf5YMS96ctmi9yZgXLNmTIBk0EtZ0Jf_obu4plC-p1nL-64rje_-URfGo3ZhjKWu3YvqY6EKCErRQjX3UGUNODkbA46u3N9JeHUrYYvGL9sc_bq4GPK9yjbFnBOON82goK9GRe9HRbdCt7q8uCS8uN3CG_zvbLS_AVIKuFQ</recordid><startdate>20190630</startdate><enddate>20190630</enddate><creator>Calgin, Mustafa Kerem</creator><creator>Cetinkol, Yeliz</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><general>Professional Medical Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190630</creationdate><title>Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients</title><author>Calgin, Mustafa Kerem ; Cetinkol, Yeliz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-c99241c04a1a903d2dc80585449476f6eaf01900c07c05b95d2ab61fc2a526c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Bacterial infections</topic><topic>Carcinoma</topic><topic>Care and treatment</topic><topic>Chronic illnesses</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B virus</topic><topic>Hepatocellular carcinoma</topic><topic>Infection</topic><topic>Infections</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Microbiota</topic><topic>Nervous system</topic><topic>Original</topic><topic>Patients</topic><topic>Permeability</topic><topic>Public health</topic><topic>Small intestine</topic><topic>Studies</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calgin, Mustafa Kerem</creatorcontrib><creatorcontrib>Cetinkol, Yeliz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pakistan journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calgin, Mustafa Kerem</au><au>Cetinkol, Yeliz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients</atitle><jtitle>Pakistan journal of medical sciences</jtitle><addtitle>Pak J Med Sci</addtitle><date>2019-06-30</date><risdate>2019</risdate><volume>35</volume><issue>3</issue><spage>847</spage><epage>851</epage><pages>847-851</pages><issn>1682-024X</issn><eissn>1681-715X</eissn><abstract>Liver and intestines are anatomically and physiologically linked. Zonulin is a protein modulating intercellular tight junctions and regulating intestinal permeability. Copeptin was studied as a marker of systemic circulation disorders in research about vasopressin and was associated with liver disease prognosis. Serum zonulin and copeptin levels were measured in patients with diagnosis of chronic hepatitis B (CHB) with the aim of easing antiviral treatment management in clinical applications and to investigate the association with normal population and viral load.
Analysis included the serum of 30 CHB patients and 17 controls. HBV-DNA real-time PCR tests were completed. CHB patients were divided into three subgroups according to viral load in serum. Zonulin and copeptin levels were measured using ELISA kits.
Serum zonulin and copeptin levels were significantly low in CHB patients compared to controls (p<0.001). When CHB subgroups are investigated in terms of serum zonulin and copeptin levels, there was an inverse correlation observed with significant difference (p<0.01, p<0.05).
The negative correlation between serum zonulin and copeptin with HBV-DNA load revealed in our study shows they may be used to monitor treatment. Zonulin and copeptin assays provide the possibility of developing new approaches to CHB diagnosis and monitoring.</abstract><cop>Pakistan</cop><pub>Knowledge Bylanes</pub><pmid>31258605</pmid><doi>10.12669/pjms.35.3.144</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1682-024X |
| ispartof | Pakistan journal of medical sciences, 2019-06, Vol.35 (3), p.847-851 |
| issn | 1682-024X 1681-715X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6572940 |
| source | DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Age Bacterial infections Carcinoma Care and treatment Chronic illnesses Deoxyribonucleic acid Development and progression DNA Health aspects Hepatitis Hepatitis B Hepatitis B virus Hepatocellular carcinoma Infection Infections Liver cirrhosis Liver diseases Microbiota Nervous system Original Patients Permeability Public health Small intestine Studies Variance analysis |
| title | Decreased levels of serum zonulin and copeptin in chronic Hepatitis-B patients |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T09%3A52%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decreased%20levels%20of%20serum%20zonulin%20and%20copeptin%20in%20chronic%20Hepatitis-B%20patients&rft.jtitle=Pakistan%20journal%20of%20medical%20sciences&rft.au=Calgin,%20Mustafa%20Kerem&rft.date=2019-06-30&rft.volume=35&rft.issue=3&rft.spage=847&rft.epage=851&rft.pages=847-851&rft.issn=1682-024X&rft.eissn=1681-715X&rft_id=info:doi/10.12669/pjms.35.3.144&rft_dat=%3Cgale_pubme%3EA592340991%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2348771447&rft_id=info:pmid/31258605&rft_galeid=A592340991&rfr_iscdi=true |