Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins

Phospholipid homeostasis in biological membranes is essential to maintain functions of organelles such as the endoplasmic reticulum. Phospholipid perturbation has been associated to cellular stress responses. However, in most cases, the implication of membrane lipid changes to homeostatic cellular r...

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Veröffentlicht in:	Scientific reports 2019-06, Vol.9 (1), p.8637-15, Article 8637
Hauptverfasser:	Shyu, Peter, Ng, Benjamin S. H., Ho, Nurulain, Chaw, Ruijie, Seah, Yi Ling, Marvalim, Charlie, Thibault, Guillaume
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/19 631/45/287/1194 631/80/470/1463 82/1 82/111 82/16 82/80 Biological membranes Cellular stress response Cytosol - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress Endoplasmic Reticulum-Associated Degradation Homeostasis Humanities and Social Sciences Lipid bilayers Lipid Bilayers - metabolism Lipids Lysine - metabolism Membrane Fluidity Membrane Lipids - metabolism Membrane proteins Membrane Proteins - chemistry Membrane Proteins - metabolism Models, Biological multidisciplinary Organelles Phosphatidylcholines - metabolism Phospholipids Phospholipids - metabolism Potassium Protein Binding Protein Domains Protein folding Protein Stability Proteins Quality control Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary)
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