Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort
The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography...
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| Veröffentlicht in: | Journal of clinical medicine 2019-05, Vol.8 (5), p.712 |
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| creator | Kang, Dong Oh Park, So Yeon Choi, Byoung Geol Na, Jin Oh Choi, Cheol Ung Kim, Eung Ju Rha, Seung-Woon Park, Chang Gyu Hong, Suk-Joo Seo, Hong Seog |
| description | The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male |
| doi_str_mv | 10.3390/jcm8050712 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6571815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2232092015</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-cd0e28649d307da0f3664e3856613c95fd75585c3ceceb47ac831e557f3e279d3</originalsourceid><addsrcrecordid>eNpVUU1v1DAUjBCIVqUXfgDyESGl-COOsxyQolCg0q5AWjhHrvOy68WxFz9n0f4zfl5dWkp5l3mS582MNUXxktELIRb07c5MDZVUMf6kOOVUqZKKRjx9tJ8U54g7mqdpKs7U8-JEMEYXjIvT4vfXGDY-YLKGXE17bRIJI1mGX2T9Axwk7chqRuOArDQiCT7jLkTSDgeICKTTcbDhoNHMTkdyeQCfkFhPuhCD1_FI2pggwweLoBHekZZkyz14tOlI1iZEKFc6mS0MpPXaHdHibQRN1tZvsm-XFSEbOld2YcpbF7YhphfFs1E7hPN7PCu-f7z81n0ul18-XXXtsjRVVaXSDBR4U1eLQVA1aDqKuq5ANLKumTALOQ5KykYaYcDAdaW0aQQDKdUogKt8dVa8v9Pdz9cTDCanidr1-2in_Ls-aNv__-Lttt-EQ19LxRoms8Dre4EYfs6AqZ8sGnBOewgz9pwLThec_qG-uaOaGBAjjA82jPa3bff_2s7kV4-DPVD_dituAItmqEs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2232092015</pqid></control><display><type>article</type><title>Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Kang, Dong Oh ; Park, So Yeon ; Choi, Byoung Geol ; Na, Jin Oh ; Choi, Cheol Ung ; Kim, Eung Ju ; Rha, Seung-Woon ; Park, Chang Gyu ; Hong, Suk-Joo ; Seo, Hong Seog</creator><creatorcontrib>Kang, Dong Oh ; Park, So Yeon ; Choi, Byoung Geol ; Na, Jin Oh ; Choi, Cheol Ung ; Kim, Eung Ju ; Rha, Seung-Woon ; Park, Chang Gyu ; Hong, Suk-Joo ; Seo, Hong Seog</creatorcontrib><description><![CDATA[The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male <31.00 cm
/m
, female <25.00 cm
/m
) were obtained. The primary outcome was 3-year all-cause mortality and the secondary outcome was 3-year major adverse cardiovascular events (MACEs). Low L1 SMI was present in 141 (29.7%) of 475 patients. The incidence of all-cause mortality (23.7% vs. 5.9%,
< 0.001) and MACEs (39.6% vs. 11.8%,
< 0.001) was significantly higher in patients with low L1 SMI than in those with high L1 SMI. In multivariate analysis, low L1 SMI was an independent predictor of higher risk of all-cause mortality (hazard ratio (HR): 4.07; 95% confidence interval (CI): 1.95-8.45;
< 0.001) and MACEs (HR: 3.76; 95% CI: 2.27-6.23;
< 0.001). These findings remained consistent after propensity score-matched analysis with 91 patient pairs (C-statistic = 0.848). CT-diagnosed low skeletal muscle mass is a powerful predictor of adverse outcomes in patients with CAD undergoing PCI.]]></description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm8050712</identifier><identifier>PMID: 31109123</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><ispartof>Journal of clinical medicine, 2019-05, Vol.8 (5), p.712</ispartof><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-cd0e28649d307da0f3664e3856613c95fd75585c3ceceb47ac831e557f3e279d3</citedby><cites>FETCH-LOGICAL-c444t-cd0e28649d307da0f3664e3856613c95fd75585c3ceceb47ac831e557f3e279d3</cites><orcidid>0000-0002-5187-8310 ; 0000-0003-2322-6267 ; 0000-0002-3228-7988</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571815/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571815/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31109123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Dong Oh</creatorcontrib><creatorcontrib>Park, So Yeon</creatorcontrib><creatorcontrib>Choi, Byoung Geol</creatorcontrib><creatorcontrib>Na, Jin Oh</creatorcontrib><creatorcontrib>Choi, Cheol Ung</creatorcontrib><creatorcontrib>Kim, Eung Ju</creatorcontrib><creatorcontrib>Rha, Seung-Woon</creatorcontrib><creatorcontrib>Park, Chang Gyu</creatorcontrib><creatorcontrib>Hong, Suk-Joo</creatorcontrib><creatorcontrib>Seo, Hong Seog</creatorcontrib><title>Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description><![CDATA[The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male <31.00 cm
/m
, female <25.00 cm
/m
) were obtained. The primary outcome was 3-year all-cause mortality and the secondary outcome was 3-year major adverse cardiovascular events (MACEs). Low L1 SMI was present in 141 (29.7%) of 475 patients. The incidence of all-cause mortality (23.7% vs. 5.9%,
< 0.001) and MACEs (39.6% vs. 11.8%,
< 0.001) was significantly higher in patients with low L1 SMI than in those with high L1 SMI. In multivariate analysis, low L1 SMI was an independent predictor of higher risk of all-cause mortality (hazard ratio (HR): 4.07; 95% confidence interval (CI): 1.95-8.45;
< 0.001) and MACEs (HR: 3.76; 95% CI: 2.27-6.23;
< 0.001). These findings remained consistent after propensity score-matched analysis with 91 patient pairs (C-statistic = 0.848). CT-diagnosed low skeletal muscle mass is a powerful predictor of adverse outcomes in patients with CAD undergoing PCI.]]></description><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVUU1v1DAUjBCIVqUXfgDyESGl-COOsxyQolCg0q5AWjhHrvOy68WxFz9n0f4zfl5dWkp5l3mS582MNUXxktELIRb07c5MDZVUMf6kOOVUqZKKRjx9tJ8U54g7mqdpKs7U8-JEMEYXjIvT4vfXGDY-YLKGXE17bRIJI1mGX2T9Axwk7chqRuOArDQiCT7jLkTSDgeICKTTcbDhoNHMTkdyeQCfkFhPuhCD1_FI2pggwweLoBHekZZkyz14tOlI1iZEKFc6mS0MpPXaHdHibQRN1tZvsm-XFSEbOld2YcpbF7YhphfFs1E7hPN7PCu-f7z81n0ul18-XXXtsjRVVaXSDBR4U1eLQVA1aDqKuq5ANLKumTALOQ5KykYaYcDAdaW0aQQDKdUogKt8dVa8v9Pdz9cTDCanidr1-2in_Ls-aNv__-Lttt-EQ19LxRoms8Dre4EYfs6AqZ8sGnBOewgz9pwLThec_qG-uaOaGBAjjA82jPa3bff_2s7kV4-DPVD_dituAItmqEs</recordid><startdate>20190519</startdate><enddate>20190519</enddate><creator>Kang, Dong Oh</creator><creator>Park, So Yeon</creator><creator>Choi, Byoung Geol</creator><creator>Na, Jin Oh</creator><creator>Choi, Cheol Ung</creator><creator>Kim, Eung Ju</creator><creator>Rha, Seung-Woon</creator><creator>Park, Chang Gyu</creator><creator>Hong, Suk-Joo</creator><creator>Seo, Hong Seog</creator><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5187-8310</orcidid><orcidid>https://orcid.org/0000-0003-2322-6267</orcidid><orcidid>https://orcid.org/0000-0002-3228-7988</orcidid></search><sort><creationdate>20190519</creationdate><title>Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort</title><author>Kang, Dong Oh ; Park, So Yeon ; Choi, Byoung Geol ; Na, Jin Oh ; Choi, Cheol Ung ; Kim, Eung Ju ; Rha, Seung-Woon ; Park, Chang Gyu ; Hong, Suk-Joo ; Seo, Hong Seog</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-cd0e28649d307da0f3664e3856613c95fd75585c3ceceb47ac831e557f3e279d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Dong Oh</creatorcontrib><creatorcontrib>Park, So Yeon</creatorcontrib><creatorcontrib>Choi, Byoung Geol</creatorcontrib><creatorcontrib>Na, Jin Oh</creatorcontrib><creatorcontrib>Choi, Cheol Ung</creatorcontrib><creatorcontrib>Kim, Eung Ju</creatorcontrib><creatorcontrib>Rha, Seung-Woon</creatorcontrib><creatorcontrib>Park, Chang Gyu</creatorcontrib><creatorcontrib>Hong, Suk-Joo</creatorcontrib><creatorcontrib>Seo, Hong Seog</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Dong Oh</au><au>Park, So Yeon</au><au>Choi, Byoung Geol</au><au>Na, Jin Oh</au><au>Choi, Cheol Ung</au><au>Kim, Eung Ju</au><au>Rha, Seung-Woon</au><au>Park, Chang Gyu</au><au>Hong, Suk-Joo</au><au>Seo, Hong Seog</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2019-05-19</date><risdate>2019</risdate><volume>8</volume><issue>5</issue><spage>712</spage><pages>712-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract><![CDATA[The impact of sarcopenia on atherosclerotic cardiovascular disease remains unclear. We aimed to investigate the prognostic impact of sarcopenia on coronary artery disease (CAD). A total of 475 patients with CAD who underwent successful percutaneous coronary intervention (PCI) and computed tomography (CT) were enrolled. The cross-sectional area of skeletal muscle at the first lumbar (L1) vertebral level was measured, and sex-specific cut-off values of L1 skeletal muscle index (L1 SMI; male <31.00 cm
/m
, female <25.00 cm
/m
) were obtained. The primary outcome was 3-year all-cause mortality and the secondary outcome was 3-year major adverse cardiovascular events (MACEs). Low L1 SMI was present in 141 (29.7%) of 475 patients. The incidence of all-cause mortality (23.7% vs. 5.9%,
< 0.001) and MACEs (39.6% vs. 11.8%,
< 0.001) was significantly higher in patients with low L1 SMI than in those with high L1 SMI. In multivariate analysis, low L1 SMI was an independent predictor of higher risk of all-cause mortality (hazard ratio (HR): 4.07; 95% confidence interval (CI): 1.95-8.45;
< 0.001) and MACEs (HR: 3.76; 95% CI: 2.27-6.23;
< 0.001). These findings remained consistent after propensity score-matched analysis with 91 patient pairs (C-statistic = 0.848). CT-diagnosed low skeletal muscle mass is a powerful predictor of adverse outcomes in patients with CAD undergoing PCI.]]></abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>31109123</pmid><doi>10.3390/jcm8050712</doi><orcidid>https://orcid.org/0000-0002-5187-8310</orcidid><orcidid>https://orcid.org/0000-0003-2322-6267</orcidid><orcidid>https://orcid.org/0000-0002-3228-7988</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Prognostic Impact of Low Skeletal Muscle Mass on Major Adverse Cardiovascular Events in Coronary Artery Disease: A Propensity Score-Matched Analysis of a Single Center All-Comer Cohort |
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