Opposing roles of TCF7/LEF1 and TCF7L2 in cyclin D2 and Bmp4 expression and cardiomyocyte cell cycle control during late heart development

Bone morphogenetic protein (BMP) and Wnt pathways regulate cell proliferation and differentiation, but how these two pathways interact and mediate their nuclear actions in the heart, especially during late cardiac development, remains poorly defined. T-cell factor (TCF) and lymphoid enhancer factor...

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Veröffentlicht in:	Laboratory investigation 2019-06, Vol.99 (6), p.807-818
Hauptverfasser:	Ye, Bo, Li, Liwen, Xu, Haodong, Chen, Yiping, Li, Faqian
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/89 14 14/19 38 38/77 631/80/86/2368 64 64/60 692/308/1426 96/95 Alternative splicing Animals Bone morphogenetic protein 4 Bone Morphogenetic Protein 4 - metabolism Cardiomyocytes Cell cycle Cell Cycle Checkpoints Cell proliferation Clonal deletion Cyclin D2 Cyclin D2 - metabolism Endothelial cells Families & family life Fetuses Heart Heart - embryology Hepatocyte Nuclear Factor 1-alpha - metabolism Homology Laboratory Medicine LEF protein Lymphocytes T Lymphoid Enhancer-Binding Factor 1 - metabolism Medicine Medicine & Public Health Mesenchyme Mice, Transgenic Myocardium - metabolism Myocytes, Cardiac - physiology Nuclei (cytology) Pathology Regulatory sequences Smad Proteins - metabolism Transcription activation Transcription Factor 7-Like 2 Protein - metabolism Transcription factors Wnt protein Wnt Signaling Pathway β-Catenin
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