Distribution and lateral mobility of glycine receptors on cultured spinal cord neurons

Strychnine is one of the most potent antagonists of glycine-mediated inhibitory conductances in the mammalian spinal cord. In order to examine the distribution of glycine receptors (GlyRs) on neuronal cells, 2 novel fluorescent strychnine derivatives were synthesized and characterized chemically, sp...

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Veröffentlicht in:	The Journal of neuroscience 1990-03, Vol.10 (3), p.985-995
Hauptverfasser:	Srinivasan, Y, Guzikowski, AP, Haugland, RP, Angelides, KJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Biological and medical sciences Biological Transport Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Diagnosis, Computer-Assisted Fluorescence Fundamental and applied biological sciences. Psychology Glycine - metabolism Neurons - metabolism Receptors, Glycine Receptors, Neurotransmitter - metabolism Spinal Cord - cytology Spinal Cord - metabolism Strychnine - analogs & derivatives Strychnine - metabolism Tissue Distribution Vertebrates: nervous system and sense organs
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