Electrical tuning in hair cells isolated from the chick cochlea
Tall (inner) hair cells were isolated from specific locations in the chick cochlea. The electrical membrane properties of these cells were recorded using the tight-seal whole-cell technique. Depolarizing current steps elicited damped voltage oscillations that ranged in frequency from 100 to 250 Hz a...
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| Veröffentlicht in: | The Journal of neuroscience 1988-07, Vol.8 (7), p.2460-2467 |
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| container_title | The Journal of neuroscience |
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| creator | Fuchs, PA Nagai, T Evans, MG |
| description | Tall (inner) hair cells were isolated from specific locations in the chick cochlea. The electrical membrane properties of these cells were recorded using the tight-seal whole-cell technique. Depolarizing current steps elicited damped voltage oscillations that ranged in frequency from 100 to 250 Hz among cells from the middle third of the cochlea (basal cells). The current-voltage relation obtained under voltage clamp was dominated by calcium-activated potassium current in the voltage range over which these oscillations occurred. Tall hair cells isolated from the apical tip of the cochlea (apical cells) exhibited action potentials and lower frequency voltage oscillations (5-14 Hz) during depolarizing current steps. Outward currents in these cells were 20-fold slower than those found in the basal cells. These results suggest that electrical tuning of hair cells may play a role in determining the frequency selectivity of the chick cochlea. |
| doi_str_mv | 10.1523/jneurosci.08-07-02460.1988 |
| format | Article |
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The electrical membrane properties of these cells were recorded using the tight-seal whole-cell technique. Depolarizing current steps elicited damped voltage oscillations that ranged in frequency from 100 to 250 Hz among cells from the middle third of the cochlea (basal cells). The current-voltage relation obtained under voltage clamp was dominated by calcium-activated potassium current in the voltage range over which these oscillations occurred. Tall hair cells isolated from the apical tip of the cochlea (apical cells) exhibited action potentials and lower frequency voltage oscillations (5-14 Hz) during depolarizing current steps. Outward currents in these cells were 20-fold slower than those found in the basal cells. 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Psychology ; hair cells ; Hair Cells, Auditory - physiology ; Ions ; Male ; potassium ; Vertebrates: nervous system and sense organs</subject><ispartof>The Journal of neuroscience, 1988-07, Vol.8 (7), p.2460-2467</ispartof><rights>1988 INIST-CNRS</rights><rights>1988 by Society for Neuroscience 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-3b36218dacebbb46f9b5ee4710941a9693c35c50a1f2f29e8c937bc4538b8aa23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569509/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569509/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7736873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3249237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuchs, PA</creatorcontrib><creatorcontrib>Nagai, T</creatorcontrib><creatorcontrib>Evans, MG</creatorcontrib><title>Electrical tuning in hair cells isolated from the chick cochlea</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Tall (inner) hair cells were isolated from specific locations in the chick cochlea. The electrical membrane properties of these cells were recorded using the tight-seal whole-cell technique. Depolarizing current steps elicited damped voltage oscillations that ranged in frequency from 100 to 250 Hz among cells from the middle third of the cochlea (basal cells). The current-voltage relation obtained under voltage clamp was dominated by calcium-activated potassium current in the voltage range over which these oscillations occurred. Tall hair cells isolated from the apical tip of the cochlea (apical cells) exhibited action potentials and lower frequency voltage oscillations (5-14 Hz) during depolarizing current steps. Outward currents in these cells were 20-fold slower than those found in the basal cells. These results suggest that electrical tuning of hair cells may play a role in determining the frequency selectivity of the chick cochlea.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Cell Separation</subject><subject>chick embryos</subject><subject>Chickens - physiology</subject><subject>cochlea</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hair cells</subject><subject>Hair Cells, Auditory - physiology</subject><subject>Ions</subject><subject>Male</subject><subject>potassium</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKkPhEZAsBOxSrn_iHxYgNBqgqKIS0LXleJyJi5MUO2HE2-MwoxGsWHlxvnt8rz6EnhG4IDVlr24HP6cxu3ABqgJZAeWiRFqpe2hVCF1RDuQ-WgGVUAku-UP0KOdbAJBA5Bk6Y5RryuQKvd1E76YUnI14mocw7HAYcGdDws7HmHHIY7ST3-I2jT2eOo9dF9x37EbXRW8fowetjdk_Ob7n6Ob95tv6Y3V1_eFy_e6qcrVQU8UaJihRW-t80zRctLqpveeSgObEaqGZY7WrwZKWtlR75TSTjeM1U42ylrJz9ObQezc3vd86P0zJRnOXQm_TLzPaYP5NhtCZ3fjTiFroGnQpeHksSOOP2efJ9CEvJ9rBj3M2UknBGbD_goRrRbXkBXx9AF1xkZNvT9sQMIsn8-nz5ubL9df1pQFlQJo_nsziqQw__fue0-hRTMmfH3Obi5s22cGFfMKkZELJZdkXB6wLu24fkje5tzGWUmL2-70y0ix_st9gtatt</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Fuchs, PA</creator><creator>Nagai, T</creator><creator>Evans, MG</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19880701</creationdate><title>Electrical tuning in hair cells isolated from the chick cochlea</title><author>Fuchs, PA ; Nagai, T ; Evans, MG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c568t-3b36218dacebbb46f9b5ee4710941a9693c35c50a1f2f29e8c937bc4538b8aa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Cell Separation</topic><topic>chick embryos</topic><topic>Chickens - physiology</topic><topic>cochlea</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hair cells</topic><topic>Hair Cells, Auditory - physiology</topic><topic>Ions</topic><topic>Male</topic><topic>potassium</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuchs, PA</creatorcontrib><creatorcontrib>Nagai, T</creatorcontrib><creatorcontrib>Evans, MG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuchs, PA</au><au>Nagai, T</au><au>Evans, MG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrical tuning in hair cells isolated from the chick cochlea</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>8</volume><issue>7</issue><spage>2460</spage><epage>2467</epage><pages>2460-2467</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><coden>JNRSDS</coden><abstract>Tall (inner) hair cells were isolated from specific locations in the chick cochlea. The electrical membrane properties of these cells were recorded using the tight-seal whole-cell technique. Depolarizing current steps elicited damped voltage oscillations that ranged in frequency from 100 to 250 Hz among cells from the middle third of the cochlea (basal cells). The current-voltage relation obtained under voltage clamp was dominated by calcium-activated potassium current in the voltage range over which these oscillations occurred. Tall hair cells isolated from the apical tip of the cochlea (apical cells) exhibited action potentials and lower frequency voltage oscillations (5-14 Hz) during depolarizing current steps. Outward currents in these cells were 20-fold slower than those found in the basal cells. These results suggest that electrical tuning of hair cells may play a role in determining the frequency selectivity of the chick cochlea.</abstract><cop>Washington, DC</cop><pub>Soc Neuroscience</pub><pmid>3249237</pmid><doi>10.1523/jneurosci.08-07-02460.1988</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Animals, Newborn Biological and medical sciences calcium Cell Separation chick embryos Chickens - physiology cochlea Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Electrophysiology Female Fundamental and applied biological sciences. Psychology hair cells Hair Cells, Auditory - physiology Ions Male potassium Vertebrates: nervous system and sense organs |
| title | Electrical tuning in hair cells isolated from the chick cochlea |
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