Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli
The preceding paper described a stress-related tonic activation of noradrenergic neurons of the locus coeruleus (LC) of behaving cats. The present study examined the degree to which adaptation to stress was reflected in LC unit activity. Adaptation was defined as a reduction in the magnitude of the...
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| Veröffentlicht in: | The Journal of neuroscience 1987-09, Vol.7 (9), p.2844-2848 |
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| creator | Abercrombie, ED Jacobs, BL |
| description | The preceding paper described a stress-related tonic activation of noradrenergic neurons of the locus coeruleus (LC) of behaving cats. The present study examined the degree to which adaptation to stress was reflected in LC unit activity. Adaptation was defined as a reduction in the magnitude of the physiological stress response of the animal, as reflected in plasma norepinephrine level and heart rate. Adaptation of the physiological stress response occurred after 5 repeated hourly presentations of 100 dB white noise and after 2 hr of restraint. When these stimuli ceased to elicit significant sympathoadrenal activation, they likewise ceased to elicit activation of LC single-unit activity. These results provide further support for the hypothesis that tonic elevations in LC neuronal activity are stress related and that the LC is involved in the CNS response to challenges to the organism. |
| doi_str_mv | 10.1523/jneurosci.07-09-02844.1987 |
| format | Article |
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Psychology ; Heart Rate ; Locus Coeruleus - cytology ; Male ; Neurons - physiology ; Noise ; Norepinephrine - blood ; Stress, Physiological - physiopathology ; Vertebrates: nervous system and sense organs</subject><ispartof>The Journal of neuroscience, 1987-09, Vol.7 (9), p.2844-2848</ispartof><rights>1988 INIST-CNRS</rights><rights>1987 by Society for Neuroscience 1987</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4927-52257b5d00f1e4e1aecec00c052eb4e1c2a182596fe1b9d2177df673f60d2c1d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569124/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569124/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7417469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3625276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abercrombie, ED</creatorcontrib><creatorcontrib>Jacobs, BL</creatorcontrib><title>Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>The preceding paper described a stress-related tonic activation of noradrenergic neurons of the locus coeruleus (LC) of behaving cats. The present study examined the degree to which adaptation to stress was reflected in LC unit activity. Adaptation was defined as a reduction in the magnitude of the physiological stress response of the animal, as reflected in plasma norepinephrine level and heart rate. Adaptation of the physiological stress response occurred after 5 repeated hourly presentations of 100 dB white noise and after 2 hr of restraint. When these stimuli ceased to elicit significant sympathoadrenal activation, they likewise ceased to elicit activation of LC single-unit activity. These results provide further support for the hypothesis that tonic elevations in LC neuronal activity are stress related and that the LC is involved in the CNS response to challenges to the organism.</description><subject>Adaptation, Physiological</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate</subject><subject>Locus Coeruleus - cytology</subject><subject>Male</subject><subject>Neurons - physiology</subject><subject>Noise</subject><subject>Norepinephrine - blood</subject><subject>Stress, Physiological - physiopathology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdFu1DAQRSMEKkvhE5AsBLwl2I4Tb3hAqlYFFlVUovTZ8jqTjSvHTu2kq34I_8tsd7WCJ481Z-4dzc2yd4wWrOLlpzsPcwzJ2ILKnDY55UshCtYs5bNsgUSTc0HZ82xBuaR5LaR4mb1K6Y5SKimTZ9lZWfOKy3qR_bmxfusgn72dSIQ0Bp-AhI74EHUbwUPcWkOeDH0i1pOpB-KCmRMxAeLsACvkuwjgHskQHlCQGD2lgqzXBblo9TjpyQacDMT0KGONdoiOaAd-gpakCcvUzQ4rO8zOvs5edNoleHN8z7Pbr5e_V9_zq-tv69XFVW5Ew2VecV7JTdVS2jEQwDQYMJQaWnHY4N9wzZa8auoO2KZpOZOy7WpZdjVtuWFteZ59OeiO82aA1uA6UTs1Rjvo-KiCtur_jre92oYHVVd1w7hAgY9HgRjuZ0iTGmwy4Jz2EOakmFiiH28Q_HwADQaXInQnE0bVPlT14-fl7a_rm9VaUaloo55CVftQcfjtv2ueRo8pYv_9sa8T3raL2hubTpgUTIp6v8OHA9bbbb-zEVQaMAkUZWq320nVqL1n-Rc38r8m</recordid><startdate>19870901</startdate><enddate>19870901</enddate><creator>Abercrombie, ED</creator><creator>Jacobs, BL</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>19870901</creationdate><title>Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli</title><author>Abercrombie, ED ; Jacobs, BL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4927-52257b5d00f1e4e1aecec00c052eb4e1c2a182596fe1b9d2177df673f60d2c1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adaptation, Physiological</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate</topic><topic>Locus Coeruleus - cytology</topic><topic>Male</topic><topic>Neurons - physiology</topic><topic>Noise</topic><topic>Norepinephrine - blood</topic><topic>Stress, Physiological - physiopathology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abercrombie, ED</creatorcontrib><creatorcontrib>Jacobs, BL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abercrombie, ED</au><au>Jacobs, BL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>1987-09-01</date><risdate>1987</risdate><volume>7</volume><issue>9</issue><spage>2844</spage><epage>2848</epage><pages>2844-2848</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><coden>JNRSDS</coden><abstract>The preceding paper described a stress-related tonic activation of noradrenergic neurons of the locus coeruleus (LC) of behaving cats. The present study examined the degree to which adaptation to stress was reflected in LC unit activity. Adaptation was defined as a reduction in the magnitude of the physiological stress response of the animal, as reflected in plasma norepinephrine level and heart rate. Adaptation of the physiological stress response occurred after 5 repeated hourly presentations of 100 dB white noise and after 2 hr of restraint. When these stimuli ceased to elicit significant sympathoadrenal activation, they likewise ceased to elicit activation of LC single-unit activity. These results provide further support for the hypothesis that tonic elevations in LC neuronal activity are stress related and that the LC is involved in the CNS response to challenges to the organism.</abstract><cop>Washington, DC</cop><pub>Soc Neuroscience</pub><pmid>3625276</pmid><doi>10.1523/jneurosci.07-09-02844.1987</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of neuroscience, 1987-09, Vol.7 (9), p.2844-2848 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adaptation, Physiological Analysis of Variance Animals Biological and medical sciences Cats Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Electrophysiology Female Fundamental and applied biological sciences. Psychology Heart Rate Locus Coeruleus - cytology Male Neurons - physiology Noise Norepinephrine - blood Stress, Physiological - physiopathology Vertebrates: nervous system and sense organs |
| title | Single-unit response of noradrenergic neurons in the locus coeruleus of freely moving cats. II. Adaptation to chronically presented stressful stimuli |
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