Brain spectrin(240/235) and brain spectrin(240/235E): differential expression during mouse brain development
Mouse brain contains at least 2 distinct spectrin subtypes: brain spectrin(240/235) and brain spectrin(240/235E) (Riederer et al., 1986). In this study, we demonstrate that these subtypes are differentially expressed during mouse brain development. Brain spectrin(240/235) can be detected in fetal ti...
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| Veröffentlicht in: | The Journal of neuroscience 1987-03, Vol.7 (3), p.864-874 |
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| creator | Riederer, BM Zagon, IS Goodman, SR |
| description | Mouse brain contains at least 2 distinct spectrin subtypes: brain spectrin(240/235) and brain spectrin(240/235E) (Riederer et al., 1986). In this study, we demonstrate that these subtypes are differentially expressed during mouse brain development. Brain spectrin(240/235) can be detected in fetal tissue and increases 2-fold during brain development. This subtype is enriched in the cortical cytoplasm of germinative neural cells and is also found in fibers resembling axons as early as fetal life. Brain spectrin(240/235E), which is specifically detected with antibodies to red blood cell spectrin, is below the limits of detection in fetal and neonatal brain but rapidly increases in concentration during the second postnatal week. Brain spectrin(240/235E) is confined to the cell body and dendrites of differentiating neurons and to glial cells but is not expressed in mitotic cells. This subtype is most prominent in granule cells of the cerebellum and dentate gyrus in the hippocampus. |
| doi_str_mv | 10.1523/jneurosci.07-03-00864.1987 |
| format | Article |
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In this study, we demonstrate that these subtypes are differentially expressed during mouse brain development. Brain spectrin(240/235) can be detected in fetal tissue and increases 2-fold during brain development. This subtype is enriched in the cortical cytoplasm of germinative neural cells and is also found in fibers resembling axons as early as fetal life. Brain spectrin(240/235E), which is specifically detected with antibodies to red blood cell spectrin, is below the limits of detection in fetal and neonatal brain but rapidly increases in concentration during the second postnatal week. Brain spectrin(240/235E) is confined to the cell body and dendrites of differentiating neurons and to glial cells but is not expressed in mitotic cells. 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In this study, we demonstrate that these subtypes are differentially expressed during mouse brain development. Brain spectrin(240/235) can be detected in fetal tissue and increases 2-fold during brain development. This subtype is enriched in the cortical cytoplasm of germinative neural cells and is also found in fibers resembling axons as early as fetal life. Brain spectrin(240/235E), which is specifically detected with antibodies to red blood cell spectrin, is below the limits of detection in fetal and neonatal brain but rapidly increases in concentration during the second postnatal week. Brain spectrin(240/235E) is confined to the cell body and dendrites of differentiating neurons and to glial cells but is not expressed in mitotic cells. This subtype is most prominent in granule cells of the cerebellum and dentate gyrus in the hippocampus.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocytochemistry</subject><subject>Immunochemistry</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Spectrin - classification</subject><subject>Spectrin - metabolism</subject><subject>Tissue Distribution</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkV9rFDEUxYModa1-BGEQkfZhtjeTmWTSB8Euq1aKBbXPIZPc2U3J_DHZ6eq3N7XDUsGnG3J-59yEQ8gbCktaFezstscpDNG4JYgcWA5Q83JJZS2ekEUiZF6UQJ-SBRQCcl6K8jl5EeMtAAig4ogcsaqUUvIF8RdBuz6LI5pdcP1JMp4VrDrNdG-z5r_a-vQ8s65tMWC_c9pn-GsMGKMb-sxOCdxk3TBFnO0W79APY5fgl-RZq33EV_M8Jjcf1z9Wn_Or60-Xqw9XuSmF3OWGVhVKqZtamKLVukLQaLm2jPM0OGtMne5pyw2v6hasTYcaDDd1bSxr2DF5_5A7Tk2H1qTVQXs1Btfp8FsN2ql_ld5t1Wa4U7ziEmpIAe_mgDD8nDDuVOeiQe91j-lripZcClHxBJ4_gCb1EQO2hyUU1H1X6svX9c236--rSwVCAVN_u1L3XSXz68fPPFjncpL-dtZ1NNq3QffGxQMmSkmBPsK2brPdu4Aqdtr7FErVfr8Xiqm0kv0B2s2tqw</recordid><startdate>19870301</startdate><enddate>19870301</enddate><creator>Riederer, BM</creator><creator>Zagon, IS</creator><creator>Goodman, SR</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>19870301</creationdate><title>Brain spectrin(240/235) and brain spectrin(240/235E): differential expression during mouse brain development</title><author>Riederer, BM ; Zagon, IS ; Goodman, SR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-c155e99ab87c2faa5e0aed6ad366d6a63bc82fa1f6c658f0dd6c680c6c88cd3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocytochemistry</topic><topic>Immunochemistry</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Spectrin - classification</topic><topic>Spectrin - metabolism</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riederer, BM</creatorcontrib><creatorcontrib>Zagon, IS</creatorcontrib><creatorcontrib>Goodman, SR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riederer, BM</au><au>Zagon, IS</au><au>Goodman, SR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain spectrin(240/235) and brain spectrin(240/235E): differential expression during mouse brain development</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>1987-03-01</date><risdate>1987</risdate><volume>7</volume><issue>3</issue><spage>864</spage><epage>874</epage><pages>864-874</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><coden>JNRSDS</coden><abstract>Mouse brain contains at least 2 distinct spectrin subtypes: brain spectrin(240/235) and brain spectrin(240/235E) (Riederer et al., 1986). In this study, we demonstrate that these subtypes are differentially expressed during mouse brain development. Brain spectrin(240/235) can be detected in fetal tissue and increases 2-fold during brain development. This subtype is enriched in the cortical cytoplasm of germinative neural cells and is also found in fibers resembling axons as early as fetal life. Brain spectrin(240/235E), which is specifically detected with antibodies to red blood cell spectrin, is below the limits of detection in fetal and neonatal brain but rapidly increases in concentration during the second postnatal week. Brain spectrin(240/235E) is confined to the cell body and dendrites of differentiating neurons and to glial cells but is not expressed in mitotic cells. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biological and medical sciences Brain - growth & development Brain - metabolism Cell differentiation, maturation, development, hematopoiesis Cell physiology Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Histocytochemistry Immunochemistry Mice Molecular and cellular biology Spectrin - classification Spectrin - metabolism Tissue Distribution |
| title | Brain spectrin(240/235) and brain spectrin(240/235E): differential expression during mouse brain development |
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