Global Ischemia Induces Downregulation of Glur2 mRNA and Increases AMPA Receptor-Mediated Ca2+ Influx in Hippocampal CA1 Neurons of Gerbil

Transient, severe forebrain or global ischemia leads to delayed cell death of pyramidal neurons in the hippocampal CA1. The precise molecular mechanisms underlying neuronal cell death after global ischemia are as yet unknown. Glutamate receptor-mediated Ca2+ influx is thought to play a critical role...

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Veröffentlicht in:	The Journal of neuroscience 1997-08, Vol.17 (16), p.6179-6188
Hauptverfasser:	Gorter, Jan A, Petrozzino, Jeffrey J, Aronica, Eleonora M, Rosenbaum, Daniel M, Opitz, Thoralf, Bennett, Michael V. L, Connor, John A, Zukin, R. Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - genetics Brain Ischemia - metabolism Calcium - metabolism Electrophysiology Gene Expression - physiology Gerbillinae Hippocampus - blood supply Hippocampus - cytology Image Processing, Computer-Assisted Male Nerve Degeneration - physiology Pyramidal Cells - chemistry Pyramidal Cells - metabolism Receptors, AMPA - chemistry Receptors, AMPA - genetics RNA, Messenger - metabolism
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