HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma
Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, w...
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| Veröffentlicht in: | International journal of biological sciences 2019-01, Vol.15 (6), p.1139-1147 |
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| container_title | International journal of biological sciences |
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| creator | Chen, Tianchi Zhou, Lingfeng Zhou, Yuan Zhou, Wuhua Huang, Hechen Yin, Shengyong Xie, Haiyang Zhou, Lin Zheng, Shusen |
| description | Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, we found that HJURP knockdown significantly reduced the migration and invasion abilities of HCC cells both
and
by interacting with Sphingosine kinase1 (SPHK1). Conversely, HJURP overexpression enhanced these biological abilities. Moreover, high HJURP expression is related to poor prognosis of HCC patients. In conclusion, HJURP plays an important role in tumor metastasis by upregulating SPHK1. And high HJURP expression may predict a lower disease-free survival rate and higher possibility of microvascular invasion in HCC patients. |
| doi_str_mv | 10.7150/ijbs.30904 |
| format | Article |
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and
by interacting with Sphingosine kinase1 (SPHK1). Conversely, HJURP overexpression enhanced these biological abilities. Moreover, high HJURP expression is related to poor prognosis of HCC patients. In conclusion, HJURP plays an important role in tumor metastasis by upregulating SPHK1. And high HJURP expression may predict a lower disease-free survival rate and higher possibility of microvascular invasion in HCC patients.</description><identifier>ISSN: 1449-2288</identifier><identifier>EISSN: 1449-2288</identifier><identifier>DOI: 10.7150/ijbs.30904</identifier><identifier>PMID: 31223275</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - physiology ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; DNA-Binding Proteins - metabolism ; DNA-Binding Proteins - physiology ; Epithelial-Mesenchymal Transition ; Hepatocellular carcinoma ; Humans ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Medical prognosis ; Mesenchyme ; Metastases ; Microvasculature ; Neoplasm Metastasis - genetics ; Research Paper ; Up-Regulation</subject><ispartof>International journal of biological sciences, 2019-01, Vol.15 (6), p.1139-1147</ispartof><rights>Copyright BioMed Central 2019</rights><rights>Ivyspring International Publisher 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-e0b6501c725ba2d49e88c9e35b7938719b7f613f1dc6a84f1407eaae9fe8d9e23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567799/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567799/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31223275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Tianchi</creatorcontrib><creatorcontrib>Zhou, Lingfeng</creatorcontrib><creatorcontrib>Zhou, Yuan</creatorcontrib><creatorcontrib>Zhou, Wuhua</creatorcontrib><creatorcontrib>Huang, Hechen</creatorcontrib><creatorcontrib>Yin, Shengyong</creatorcontrib><creatorcontrib>Xie, Haiyang</creatorcontrib><creatorcontrib>Zhou, Lin</creatorcontrib><creatorcontrib>Zheng, Shusen</creatorcontrib><title>HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma</title><title>International journal of biological sciences</title><addtitle>Int J Biol Sci</addtitle><description>Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, we found that HJURP knockdown significantly reduced the migration and invasion abilities of HCC cells both
and
by interacting with Sphingosine kinase1 (SPHK1). Conversely, HJURP overexpression enhanced these biological abilities. Moreover, high HJURP expression is related to poor prognosis of HCC patients. In conclusion, HJURP plays an important role in tumor metastasis by upregulating SPHK1. And high HJURP expression may predict a lower disease-free survival rate and higher possibility of microvascular invasion in HCC patients.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - physiology</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Hepatocellular carcinoma</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical prognosis</subject><subject>Mesenchyme</subject><subject>Metastases</subject><subject>Microvasculature</subject><subject>Neoplasm Metastasis - genetics</subject><subject>Research Paper</subject><subject>Up-Regulation</subject><issn>1449-2288</issn><issn>1449-2288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV9rFDEUxQdRbK2--AEk4EsRps3_TF4EWVpXrbho9zlksnd2s8wkY5Ip9Ns7a2upfboXzo9z7-FU1VuCzxQR-Nzv23zGsMb8WXVMONc1pU3z_NF-VL3KeY8xk6LBL6sjRihlVInjqlt-Xf9coVWKQyyQ0cXoyw56b_u6xPo7ZAhudzvYHl0nG7IvPgZ04y1ajwm2U2-LD1v0a7X8RpAPaAmjLdFB389SQgubnA9xsK-rF53tM7y5nyfV-vLierGsr358_rL4dFU7jmWpAbdSYOIUFa2lG66haZwGJlqlWaOIblUnCevIxknb8I5wrMBa0B00Gw2UnVQf73zHqR1g4yCUZHszJj_YdGui9eZ_Jfid2cYbI4VUSuvZ4PTeIMXfE-RiBp8PeWyAOGVDKReSYk4Pt94_QfdxSmGON1OCSsYIkTP14Y5yKeacoHt4hmBzqM8c6jN_65vhd4_ff0D_9cX-AKUQlz0</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Chen, Tianchi</creator><creator>Zhou, Lingfeng</creator><creator>Zhou, Yuan</creator><creator>Zhou, Wuhua</creator><creator>Huang, Hechen</creator><creator>Yin, Shengyong</creator><creator>Xie, Haiyang</creator><creator>Zhou, Lin</creator><creator>Zheng, Shusen</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190101</creationdate><title>HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma</title><author>Chen, Tianchi ; Zhou, Lingfeng ; Zhou, Yuan ; Zhou, Wuhua ; Huang, Hechen ; Yin, Shengyong ; Xie, Haiyang ; Zhou, Lin ; Zheng, Shusen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-e0b6501c725ba2d49e88c9e35b7938719b7f613f1dc6a84f1407eaae9fe8d9e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - physiology</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Line, Tumor</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Hepatocellular carcinoma</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Medical prognosis</topic><topic>Mesenchyme</topic><topic>Metastases</topic><topic>Microvasculature</topic><topic>Neoplasm Metastasis - genetics</topic><topic>Research Paper</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Tianchi</creatorcontrib><creatorcontrib>Zhou, Lingfeng</creatorcontrib><creatorcontrib>Zhou, Yuan</creatorcontrib><creatorcontrib>Zhou, Wuhua</creatorcontrib><creatorcontrib>Huang, Hechen</creatorcontrib><creatorcontrib>Yin, Shengyong</creatorcontrib><creatorcontrib>Xie, Haiyang</creatorcontrib><creatorcontrib>Zhou, Lin</creatorcontrib><creatorcontrib>Zheng, Shusen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Tianchi</au><au>Zhou, Lingfeng</au><au>Zhou, Yuan</au><au>Zhou, Wuhua</au><au>Huang, Hechen</au><au>Yin, Shengyong</au><au>Xie, Haiyang</au><au>Zhou, Lin</au><au>Zheng, Shusen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma</atitle><jtitle>International journal of biological sciences</jtitle><addtitle>Int J Biol Sci</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>15</volume><issue>6</issue><spage>1139</spage><epage>1147</epage><pages>1139-1147</pages><issn>1449-2288</issn><eissn>1449-2288</eissn><abstract>Holliday Junction Recognition Protein (HJURP) is involved in various cancers including hepatocellular carcinoma (HCC). Current studies have showed that HJURP is correlated with HCC proliferation. However, the role of HJURP in HCC Epithelial-to-Mesenchymal Transition remains unclear. In this study, we found that HJURP knockdown significantly reduced the migration and invasion abilities of HCC cells both
and
by interacting with Sphingosine kinase1 (SPHK1). Conversely, HJURP overexpression enhanced these biological abilities. Moreover, high HJURP expression is related to poor prognosis of HCC patients. In conclusion, HJURP plays an important role in tumor metastasis by upregulating SPHK1. And high HJURP expression may predict a lower disease-free survival rate and higher possibility of microvascular invasion in HCC patients.</abstract><cop>Australia</cop><pub>Ivyspring International Publisher Pty Ltd</pub><pmid>31223275</pmid><doi>10.7150/ijbs.30904</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Epithelial-Mesenchymal Transition Hepatocellular carcinoma Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Medical prognosis Mesenchyme Metastases Microvasculature Neoplasm Metastasis - genetics Research Paper Up-Regulation |
| title | HJURP Promotes Epithelial-to-Mesenchymal Transition via Upregulating SPHK1 in Hepatocellular Carcinoma |
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