Semaphorin 4D promotes the proliferation and metastasis of bladder cancer by activating the PI3K/AKT pathway

The present study aimed to investigate the role of semaphorin 4D (Sema4D) in bladder cancer cell proliferation and metastasis in vivo and in vitro. Effects of Sema4D modulation on cancer cell viability and clonogenic abilities were assessed by MTT assay and colony formation assay. Cell apoptosis, ce...

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Veröffentlicht in:	Tumori 2019-06, Vol.105 (3), p.231-242
Hauptverfasser:	Lu, Jian-jun, Su, Yao-wu, Wang, Chao-jun, Li, Di-feng, Zhou, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Apoptosis - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cell Survival - genetics Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Humans Mice Neoplasm Metastasis Original s Phosphatidylinositol 3-Kinases - genetics Proto-Oncogene Proteins c-akt - genetics Semaphorins - genetics Signal Transduction - genetics Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Xenograft Model Antitumor Assays
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