Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats
Diabetic cardiomyopathy (DCM), one of the common diabetic complications, causes a high rate of mortality in patients with diabetes. Tanshinone IIA (TSIIA), one of the components of (Danshen), has anti-oxidative stress activity and is widely used to treat diabetes-associated diseases. However, its ef...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2019-07, Vol.18 (1), p.729-734 |
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| creator | Tao, Shuliang Chen, Liuyin Song, Jingmei Zhu, Ningning Song, Xueyi Shi, Ruoli Ge, Gangfeng Zhang, Yueming |
| description | Diabetic cardiomyopathy (DCM), one of the common diabetic complications, causes a high rate of mortality in patients with diabetes. Tanshinone IIA (TSIIA), one of the components of
(Danshen), has anti-oxidative stress activity and is widely used to treat diabetes-associated diseases. However, its efficacy on DCM remains unclear. The present study aimed to investigate the potential therapeutic function of TSIIA on DCM in an experimental diabetic rat model. Streptozotocin (STZ)-induced diabetic rats were intraperitoneally injected with TSIIA for 6 weeks. The present results indicated that blood glucose concentration was slightly reduced in the low-dose TSIIA treatment group. TSIIA injection was also noted to improve cardiac function, and restore loss of mitochondrial cristae, swollen mitochondrial matrix and disorganized myofibrils in myocardial cells, which are thought to be characteristics of apoptosis. Furthermore, TSIIA injection could increase the activity of superoxide dismutase in STZ-induced diabetic rats, and suppress the endoplasmic reticulum (ER) stress signaling pathway via reducing the expression of glucose-regulated protein 78 and C/EBP homologous protein. These results provide evidence that TSIIA may ameliorate DCM in diabetic rats, possibly via suppressing oxidative stress and ER stress activation. |
| doi_str_mv | 10.3892/etm.2019.7580 |
| format | Article |
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(Danshen), has anti-oxidative stress activity and is widely used to treat diabetes-associated diseases. However, its efficacy on DCM remains unclear. The present study aimed to investigate the potential therapeutic function of TSIIA on DCM in an experimental diabetic rat model. Streptozotocin (STZ)-induced diabetic rats were intraperitoneally injected with TSIIA for 6 weeks. The present results indicated that blood glucose concentration was slightly reduced in the low-dose TSIIA treatment group. TSIIA injection was also noted to improve cardiac function, and restore loss of mitochondrial cristae, swollen mitochondrial matrix and disorganized myofibrils in myocardial cells, which are thought to be characteristics of apoptosis. Furthermore, TSIIA injection could increase the activity of superoxide dismutase in STZ-induced diabetic rats, and suppress the endoplasmic reticulum (ER) stress signaling pathway via reducing the expression of glucose-regulated protein 78 and C/EBP homologous protein. These results provide evidence that TSIIA may ameliorate DCM in diabetic rats, possibly via suppressing oxidative stress and ER stress activation.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2019.7580</identifier><identifier>PMID: 31258708</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Apoptosis ; Blood glucose ; Cardiac function ; Cardiomyocytes ; Cardiomyopathy ; Diabetes ; Glucose ; Health aspects ; Heart ; Hyperglycemia ; Laboratory animals ; Myocardial diseases ; Oxidative stress ; Pathogenesis ; Protein folding ; Rodents ; Scientific equipment industry ; Standard deviation ; Studies ; Superoxides ; Transmission electron microscopy</subject><ispartof>Experimental and therapeutic medicine, 2019-07, Vol.18 (1), p.729-734</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright © 2019, Spandidos Publications 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-c481deefeb091d14c78c9d6afa385e4d751ea04ac05fd1a5e3a080a5db3a5893</citedby><cites>FETCH-LOGICAL-c412t-c481deefeb091d14c78c9d6afa385e4d751ea04ac05fd1a5e3a080a5db3a5893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566023/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566023/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31258708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tao, Shuliang</creatorcontrib><creatorcontrib>Chen, Liuyin</creatorcontrib><creatorcontrib>Song, Jingmei</creatorcontrib><creatorcontrib>Zhu, Ningning</creatorcontrib><creatorcontrib>Song, Xueyi</creatorcontrib><creatorcontrib>Shi, Ruoli</creatorcontrib><creatorcontrib>Ge, Gangfeng</creatorcontrib><creatorcontrib>Zhang, Yueming</creatorcontrib><title>Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>Diabetic cardiomyopathy (DCM), one of the common diabetic complications, causes a high rate of mortality in patients with diabetes. Tanshinone IIA (TSIIA), one of the components of
(Danshen), has anti-oxidative stress activity and is widely used to treat diabetes-associated diseases. However, its efficacy on DCM remains unclear. The present study aimed to investigate the potential therapeutic function of TSIIA on DCM in an experimental diabetic rat model. Streptozotocin (STZ)-induced diabetic rats were intraperitoneally injected with TSIIA for 6 weeks. The present results indicated that blood glucose concentration was slightly reduced in the low-dose TSIIA treatment group. TSIIA injection was also noted to improve cardiac function, and restore loss of mitochondrial cristae, swollen mitochondrial matrix and disorganized myofibrils in myocardial cells, which are thought to be characteristics of apoptosis. Furthermore, TSIIA injection could increase the activity of superoxide dismutase in STZ-induced diabetic rats, and suppress the endoplasmic reticulum (ER) stress signaling pathway via reducing the expression of glucose-regulated protein 78 and C/EBP homologous protein. These results provide evidence that TSIIA may ameliorate DCM in diabetic rats, possibly via suppressing oxidative stress and ER stress activation.</description><subject>Apoptosis</subject><subject>Blood glucose</subject><subject>Cardiac function</subject><subject>Cardiomyocytes</subject><subject>Cardiomyopathy</subject><subject>Diabetes</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Hyperglycemia</subject><subject>Laboratory animals</subject><subject>Myocardial diseases</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Protein folding</subject><subject>Rodents</subject><subject>Scientific equipment industry</subject><subject>Standard deviation</subject><subject>Studies</subject><subject>Superoxides</subject><subject>Transmission electron microscopy</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkkFr3DAQhU1paUKaY69F0Esv3kqyZcuXwrK0yUIghe6pFzGWxrsKtuRKdtv995XJJmlKJZCE9M0bZvSy7C2jq0I2_CNOw4pT1qxqIemL7JzVDc8ZZeLl6Uwbyc6yyxjvaBqiYlKK19lZwbiQNZXn2a8duHiwzjsk2-2awIC99QEmjMRYaHGymmgIxvrh6EeYDkfSHol1B9vaybo9uQpjLQk4QzbXt18J_h4Dxmi9SxD5tvueW2dmjeYkl3STenyTveqgj3h52i-y3ZfPu811fnN7td2sb3JdMj6lVTKD2GFLG2ZYqWupG1NBB4UUWJpaMARagqaiMwwEFkAlBWHaAoRsiovs073sOLcDGo1uCtCrMdgBwlF5sOr5i7MHtfc_VSWqivIiCXw4CQT_Y8Y4qcFGjX0PDv0cFeeCVix1mSf0_T_onZ-DS9UlqqxEUzLaPFF76FFZ1_mUVy-iap2QgsmqXtKu_kOlaXCwOn1WZ9P9s4D8PkAHH2PA7rFGRtXiFZW8ohavqMUriX_3d2Me6QdnFH8ANNm6ow</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Tao, Shuliang</creator><creator>Chen, Liuyin</creator><creator>Song, Jingmei</creator><creator>Zhu, Ningning</creator><creator>Song, Xueyi</creator><creator>Shi, Ruoli</creator><creator>Ge, Gangfeng</creator><creator>Zhang, Yueming</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Tanshinone IIA (TSIIA), one of the components of
(Danshen), has anti-oxidative stress activity and is widely used to treat diabetes-associated diseases. However, its efficacy on DCM remains unclear. The present study aimed to investigate the potential therapeutic function of TSIIA on DCM in an experimental diabetic rat model. Streptozotocin (STZ)-induced diabetic rats were intraperitoneally injected with TSIIA for 6 weeks. The present results indicated that blood glucose concentration was slightly reduced in the low-dose TSIIA treatment group. TSIIA injection was also noted to improve cardiac function, and restore loss of mitochondrial cristae, swollen mitochondrial matrix and disorganized myofibrils in myocardial cells, which are thought to be characteristics of apoptosis. Furthermore, TSIIA injection could increase the activity of superoxide dismutase in STZ-induced diabetic rats, and suppress the endoplasmic reticulum (ER) stress signaling pathway via reducing the expression of glucose-regulated protein 78 and C/EBP homologous protein. These results provide evidence that TSIIA may ameliorate DCM in diabetic rats, possibly via suppressing oxidative stress and ER stress activation.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>31258708</pmid><doi>10.3892/etm.2019.7580</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental and therapeutic medicine, 2019-07, Vol.18 (1), p.729-734 |
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| subjects | Apoptosis Blood glucose Cardiac function Cardiomyocytes Cardiomyopathy Diabetes Glucose Health aspects Heart Hyperglycemia Laboratory animals Myocardial diseases Oxidative stress Pathogenesis Protein folding Rodents Scientific equipment industry Standard deviation Studies Superoxides Transmission electron microscopy |
| title | Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats |
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