Calcium channels in rat brain synaptosomes: identification and pharmacological characterization. High affinity blockade by organic Ca2+ channel blockers

Rat brain synaptosomes are shown to contain functional voltage-sensitive Ca2+ channels that are inhibited by organic Ca2+ channel blockers. Depolarization of synaptosomes with high K+ stimulates uptake of 45Ca2+ which is biphasic in its time course. Replacement of external Na+ with choline eliminate...

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Veröffentlicht in:	The Journal of neuroscience 1985-03, Vol.5 (3), p.841-849
Hauptverfasser:	Turner, TJ, Goldin, SM
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - metabolism Calcium - antagonists & inhibitors Calcium - metabolism Calcium Channel Blockers - pharmacology Dihydropyridines Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Ion Channels - drug effects Ion Channels - physiology Isolated neuron and nerve. Neuroglia Male Nifedipine - analogs & derivatives Nifedipine - metabolism Nitrendipine Norepinephrine - metabolism Potassium - pharmacology Pyridines - pharmacology Rats Rats, Inbred Strains Synaptosomes - metabolism Vertebrates: nervous system and sense organs
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