Ron Receptor Signaling Ameliorates Hepatic Fibrosis in a Diet-Induced Nonalcoholic Steatohepatitis Mouse Model

Liver fibrosis is commonly observed in the terminal stages of nonalcoholic steatohepatitis (NASH) and with no specific and effective antifibrotic therapies available, this disease is a major global health burden. The MSP/Ron receptor axis has been shown to have anti-inflammatory properties in a numb...

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Veröffentlicht in:	Journal of proteome research 2018-09, Vol.17 (9), p.3268-3280
Hauptverfasser:	Allen, Joselyn, Zhang, Jingtao, Quickel, Michael D, Kennett, Mary, Patterson, Andrew D, Hankey-Giblin, Pamela A
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models anti-inflammatory activity apolipoprotein E blood serum collagen cytokines fatty liver fibrosis gene expression hepatocytes inflammation knockout mutants ligands liver liver cirrhosis low density lipoprotein macrophages metabolites metabolomics mice nuclear magnetic resonance spectroscopy protective effect proteome pyruvic acid very low density lipoprotein
Online-Zugang:	Volltext
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