Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

IMPORTANCE: Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular APOE alleles. OBJECTIVE: To identify APOE genotype-dependent associations with infrequent and rare variants using whole-exome...

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Veröffentlicht in:	Archives of neurology (Chicago) 2019-09, Vol.76 (9), p.1099-1108
Hauptverfasser:	Ma, Yiyi, Jun, Gyungah R, Zhang, Xiaoling, Chung, Jaeyoon, Naj, Adam C, Chen, Yuning, Bellenguez, Celine, Hamilton-Nelson, Kara, Martin, Eden R, Kunkle, Brian W, Bis, Joshua C, Debette, Stéphanie, DeStefano, Anita L, Fornage, Myriam, Nicolas, Gaël, van Duijn, Cornelia, Bennett, David A, De Jager, Philip L, Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A, Seshadri, Sudha, Lambert, Jean-Charles, Schellenberg, Gerard D, Lunetta, Kathryn L, Farrer, Lindsay A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Alzheimer's disease Apolipoprotein E Bioinformatics Cognition Cognitive ability Datasets Foxg1 protein Gene expression Gene sequencing Genomes Genotype & phenotype Genotypes Life Sciences Longitude Neurodegenerative diseases Online First Original Investigation Replication Subgroups Systematic review
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