On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas
Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these micro...
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| Veröffentlicht in: | Cancers 2019-05, Vol.11 (5), p.716 |
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| creator | Mascheroni, Pietro López Alfonso, Juan Carlos Kalli, Maria Stylianopoulos, Triantafyllos Meyer-Hermann, Michael Hatzikirou, Haralampos |
| description | Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these microenvironmental changes trigger chemo-mechanically induced cellular phenotypic transitions whose impact on therapy outcomes is not completely understood. In this work we analyze the effects of mechanical compression on migration and proliferation of glioma cells. We derive a mathematical model of glioma progression focusing on cellular phenotypic plasticity. Our results reveal a trade-off between tumor infiltration and cellular content as a consequence of stress-alleviation approaches. We discuss how these novel findings increase the current understanding of glioma/microenvironment interactions and can contribute to new strategies for improved therapeutic outcomes. |
| doi_str_mv | 10.3390/cancers11050716 |
| format | Article |
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In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, decreasing solid stresses and improving blood perfusion. However, these microenvironmental changes trigger chemo-mechanically induced cellular phenotypic transitions whose impact on therapy outcomes is not completely understood. In this work we analyze the effects of mechanical compression on migration and proliferation of glioma cells. We derive a mathematical model of glioma progression focusing on cellular phenotypic plasticity. Our results reveal a trade-off between tumor infiltration and cellular content as a consequence of stress-alleviation approaches. 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| subjects | Brain cancer Cell adhesion & migration Cell growth Cell proliferation Compression Glioma cells Investigations Mathematical models Metastases Motility Perfusion Phenotypic plasticity Tumor microenvironment Tumors |
| title | On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas |
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