Macrophages in Colorectal Cancer Liver Metastases
Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liv...
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| Veröffentlicht in: | Cancers 2019-05, Vol.11 (5), p.633 |
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| container_title | Cancers |
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| creator | Cortese, Nina Soldani, Cristiana Franceschini, Barbara Barbagallo, Marialuisa Marchesi, Federica Torzilli, Guido Donadon, Matteo |
| description | Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity, responsible for a wide array of clinical presentations and responsiveness to treatments. In the era of precision medicine, there is a critical need of reliable prognostic markers to improve patient stratification, and, for their predominance in metastatic tissues, TAMs are emerging as promising candidates. |
| doi_str_mv | 10.3390/cancers11050633 |
| format | Article |
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TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity, responsible for a wide array of clinical presentations and responsiveness to treatments. In the era of precision medicine, there is a critical need of reliable prognostic markers to improve patient stratification, and, for their predominance in metastatic tissues, TAMs are emerging as promising candidates.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers11050633</identifier><identifier>PMID: 31067629</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angiogenesis ; Antibodies ; Antigens ; Apoptosis ; Cancer therapies ; Chemokines ; Chemotherapy ; Colorectal cancer ; Colorectal carcinoma ; Cytokines ; Cytology ; Cytotoxicity ; Genotype & phenotype ; Growth factors ; Inflammation ; Ligands ; Liver cancer ; Localization ; Lymphocytes ; Macrophages ; Metastases ; Metastasis ; Microenvironments ; Precision medicine ; Proteins ; Radiation therapy ; Review ; Tumor necrosis factor-TNF ; Tumors</subject><ispartof>Cancers, 2019-05, Vol.11 (5), p.633</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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| source | MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Angiogenesis Antibodies Antigens Apoptosis Cancer therapies Chemokines Chemotherapy Colorectal cancer Colorectal carcinoma Cytokines Cytology Cytotoxicity Genotype & phenotype Growth factors Inflammation Ligands Liver cancer Localization Lymphocytes Macrophages Metastases Metastasis Microenvironments Precision medicine Proteins Radiation therapy Review Tumor necrosis factor-TNF Tumors |
| title | Macrophages in Colorectal Cancer Liver Metastases |
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