MicroRNA hsa-miR-623 directly suppresses MMP1 and attenuates IL-8-induced metastasis in pancreatic cancer

Matrix metalloproteinase‑1 (MMP1) participates in the metastasis of pancreatic cancer, and its expression can be regulated by endogenous microRNAs (miRs/miRNAs) and exogenous inflammatory factors. Whether miRNAs that potentially modulate MMP1 expression can also attenuate the pro‑metastatic effects...

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Veröffentlicht in:	International journal of oncology 2019-07, Vol.55 (1), p.142-156
Hauptverfasser:	Chen, Yutong, Peng, Siqi, Cen, Hong, Lin, Yujing, Huang, Chumei, Chen, Yinting, Shan, Hong, Su, Yonghui, Zeng, Linjuan
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Cancer metastasis Cancer prevention Cancer therapies Cell adhesion & migration Cell Line, Tumor Cell Movement Cell Proliferation Chemotherapy Computational biology Epigenetics Female Gene expression Gene Expression Regulation, Neoplastic Health aspects Health savings accounts Humans Interleukin-8 - metabolism Investigations Journalists Luciferase Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Medical prognosis Messenger RNA Metastasis Mice MicroRNA MicroRNAs MicroRNAs - genetics Neoplasm Metastasis - genetics Neoplasm Metastasis - pathology Neoplasm Transplantation Novels Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology RNA Scientific equipment industry Stem cells Tumor necrosis factor-TNF Tumors
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